ID POC1A_XENLA Reviewed; 441 AA.
AC Q7T0P4;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2012, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=POC1 centriolar protein homolog A;
DE AltName: Full=Pat-interacting protein 2;
DE Short=Pix2;
DE Short=xPix2;
DE AltName: Full=WD repeat-containing protein 51A;
GN Name=poc1a; Synonyms=wdr51a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP INTERACTION WITH PAT, AND SUBCELLULAR LOCATION.
RX PubMed=18068700; DOI=10.1016/j.yexcr.2007.10.019;
RA Hames R.S., Hames R., Prosser S.L., Euteneuer U., Lopes C.A., Moore W.,
RA Woodland H.R., Fry A.M.;
RT "Pix1 and Pix2 are novel WD40 microtubule-associated proteins that
RT colocalize with mitochondria in Xenopus germ plasm and centrosomes in human
RT cells.";
RL Exp. Cell Res. 314:574-589(2008).
CC -!- FUNCTION: May play an important role in centriole assembly and/or
CC stability and ciliogenesis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with pat. {ECO:0000269|PubMed:18068700}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:18068700}. Note=Colocalizes with mitochondria in
CC cortical germ plasm islands. The mitochondrial localization may be
CC microtubule-dependent.
CC -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH56099.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC056099; AAH56099.1; ALT_INIT; mRNA.
DR RefSeq; NP_001079883.2; NM_001086414.1.
DR AlphaFoldDB; Q7T0P4; -.
DR SMR; Q7T0P4; -.
DR MaxQB; Q7T0P4; -.
DR DNASU; 379573; -.
DR GeneID; 379573; -.
DR KEGG; xla:379573; -.
DR AGR; Xenbase:XB-GENE-5767146; -.
DR CTD; 379573; -.
DR Xenbase; XB-GENE-5767146; poc1a.L.
DR OrthoDB; 2575345at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 379573; Expressed in egg cell and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44019:SF2; POC1 CENTRIOLAR PROTEIN HOMOLOG A; 1.
DR PANTHER; PTHR44019; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..441
FT /note="POC1 centriolar protein homolog A"
FT /id="PRO_0000420364"
FT REPEAT 16..55
FT /note="WD 1"
FT REPEAT 58..97
FT /note="WD 2"
FT REPEAT 100..139
FT /note="WD 3"
FT REPEAT 142..181
FT /note="WD 4"
FT REPEAT 184..223
FT /note="WD 5"
FT REPEAT 226..265
FT /note="WD 6"
FT REPEAT 268..307
FT /note="WD 7"
FT REGION 347..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 400..427
FT /evidence="ECO:0000255"
FT COMPBIAS 358..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 48842 MW; E7226BB1BBCC52AD CRC64;
MAGQSEDPSL ERHFKGHRDT VTAVDFNANT KQLASGSMDS CLMVWNMKTQ MRAYRFVGHK
DAILSVDFSP SGHLIASASR DKTVRLWVPS VKGESTAFKA HTGTVRSVSF SGDGQSLVTA
SDDKTIKVWT VHRQKFLFSL NQHINWVRCA KFSPDGRLIV SASDDKTIKL WDKTSRECIQ
SFCEHGGFVN FVDFHPSGTC IAAAATDNTV KVWDIRMNKL IQHYQVHSGV VNSLSFHPSG
NYLITASNDS TLKVLDLLEG RLLYTLHGHQ GPVTCVKFSR EGDFFASGGS DEQVMVWKTN
FDAGSYPDLL KYRQNDTFPS GGDYTSIVQP ADVHQPARNA HVTQAADLEP HITEMSVKDR
SSPLSYTSRS VDQHHPQAED GNLQTVASTL EHIVGQLDIL TRTVGILEQR LSLTEDKLKE
CIEQQQATVP PSHSGTKKSS F
//
