ID Q7T1K1_DANRE Unreviewed; 478 AA.
AC Q7T1K1; B2GT41; F6NVL3;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 179.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN Name=traf4b {ECO:0000313|EMBL:AAI65750.1,
GN ECO:0000313|Ensembl:ENSDARP00000056877,
GN ECO:0000313|RefSeq:NP_997982.1, ECO:0000313|ZFIN:ZDB-GENE-040305-2};
GN Synonyms=traf4 {ECO:0000313|EMBL:CAD89006.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65750.1};
RN [1] {ECO:0000313|EMBL:CAD89006.1, ECO:0000313|RefSeq:NP_997982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15749085; DOI=10.1016/j.modgep.2004.10.011;
RA Kedinger V., Alpy F., Tomasetto C., Thisse C., Thisse B., Rio M.C.;
RT "Spatial and temporal distribution of the traf4 genes during zebrafish
RT development.";
RL Gene Expr. Patterns 5:545-552(2005).
RN [2] {ECO:0000313|RefSeq:NP_997982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18039395;
RA Stein C., Caccamo M., Laird G., Leptin M.;
RT "Conservation and divergence of gene families encoding components of innate
RT immune response systems in zebrafish.";
RL Genome Biol. 8:R251-R251(2007).
RN [3] {ECO:0000313|EMBL:AAI65750.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65750.1}, and Whole
RC {ECO:0000313|EMBL:AAH78361.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_997982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22915831;
RA Ahn D., You K.H., Kim C.H.;
RT "Evolution of the tbx6/16 subfamily genes in vertebrates: insights from
RT zebrafish.";
RL Mol. Biol. Evol. 29:3959-3983(2012).
RN [5] {ECO:0000313|RefSeq:NP_997982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22615868;
RA He B.L., Yuan J.M., Yang L.Y., Xie J.F., Weng S.P., Yu X.Q., He J.G.;
RT "The viral TRAF protein (ORF111L) from infectious spleen and kidney
RT necrosis virus interacts with TRADD and induces caspase 8-mediated
RT apoptosis.";
RL PLoS ONE 7:e37001-e37001(2012).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000056877}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056877};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000056877, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056877};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_997982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [9] {ECO:0000313|RefSeq:NP_997982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [10] {ECO:0000313|RefSeq:NP_997982.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR EMBL; CU463284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC078361; AAH78361.1; -; mRNA.
DR EMBL; BC165750; AAI65750.1; -; mRNA.
DR EMBL; AJ556549; CAD89006.1; -; mRNA.
DR RefSeq; NP_997982.1; NM_212817.1.
DR STRING; 7955.ENSDARP00000056877; -.
DR PaxDb; 7955-ENSDARP00000056877; -.
DR Ensembl; ENSDART00000056878; ENSDARP00000056877; ENSDARG00000038964.
DR Ensembl; ENSDART00000056878.4; ENSDARP00000056877.3; ENSDARG00000038964.4.
DR GeneID; 404035; -.
DR KEGG; dre:404035; -.
DR AGR; ZFIN:ZDB-GENE-040305-2; -.
DR CTD; 404035; -.
DR ZFIN; ZDB-GENE-040305-2; traf4b.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_021061_6_0_1; -.
DR OMA; MAHVKEG; -.
DR OrthoDB; 3088759at2759; -.
DR TreeFam; TF321154; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000038964; Expressed in mature ovarian follicle and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd03781; MATH_TRAF4; 1.
DR CDD; cd16641; mRING-HC-C3HC3D_TRAF4; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR037307; TRAF4_MATH.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF144; TNF RECEPTOR-ASSOCIATED FACTOR 4; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 4.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 3.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614};
KW Receptor {ECO:0000313|EMBL:AAH78361.1, ECO:0000313|RefSeq:NP_997982.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 18..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 101..154
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 156..208
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 210..263
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 307..470
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 101..154
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 156..208
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 210..263
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
SQ SEQUENCE 478 AA; 54920 MW; F4810C4D667347A8 CRC64;
MPGLDLKFLE RPRRKFYCPL CEKPMREPVQ VSTCGHRFCD TCLQEYLSEG VFTCPEDQLP
LDYAKIFPDL ELEQQILSLP IRCIHSEEGC RWTAQNKLLQ AHLSVCEFNV VSCPNRCSVK
LLRRELPEHL QHDCAKRKLH CDHCGEQFTG EAYENHQGVC PEESVYCENK CGARMVRRLL
AQHSVSECLK RKLPCRYCKK EFLYDTIQNH QQQCPRFPMQ CPNRCGTPGI TRDTLMAHVK
EGCSTAMVLC PFKEAGCKHR SPKTGVARHL EEAAPTHLSL LCGLVNRQRL ELRDLRRRME
ELSGSRDGTL LWKLTDFSQR LQEAKTRTSG CLELFSPAFY SHNYGYRLQV SAFLNGNGSG
EDTHMSVYLR VLPGEYDGLL EWPFPYRVSF SLLDQCDPAL TKPQHITETF SPDPTWKNFQ
RPRPGALGSI RGGCLDESML GFGYPKFISH EEMKKRNYIR DNAVFIKASI DVVQKILN
//
