ID   I2B2B_DANRE             Reviewed;         501 AA.
AC   Q7T2G1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   RecName: Full=Interferon regulatory factor 2-binding protein 2-B;
DE            Short=IRF-2-binding protein 2-B;
DE            Short=IRF-2BP2-B;
GN   Name=irf2bp2b; Synonyms=irf2bp2; ORFNames=zgc:63864;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRF2BP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC054562; AAH54562.1; -; mRNA.
DR   RefSeq; NP_999917.1; NM_214752.1.
DR   AlphaFoldDB; Q7T2G1; -.
DR   SMR; Q7T2G1; -.
DR   STRING; 7955.ENSDARP00000138346; -.
DR   PaxDb; 7955-ENSDARP00000023325; -.
DR   GeneID; 406614; -.
DR   KEGG; dre:406614; -.
DR   AGR; ZFIN:ZDB-GENE-040426-2574; -.
DR   CTD; 406614; -.
DR   ZFIN; ZDB-GENE-040426-2574; irf2bp2b.
DR   eggNOG; KOG3579; Eukaryota.
DR   InParanoid; Q7T2G1; -.
DR   OrthoDB; 4066206at2759; -.
DR   PhylomeDB; Q7T2G1; -.
DR   PRO; PR:Q7T2G1; -.
DR   Proteomes; UP000000437; Chromosome 11.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:ZFIN.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:ZFIN.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0045650; P:negative regulation of macrophage differentiation; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd16716; vRING-HC_IRF2BP2; 1.
DR   Gene3D; 1.10.10.1580; Interferon regulatory factor 2-binding protein; 1.
DR   InterPro; IPR044882; I2BP1/2_C3HC4-RING_sf.
DR   InterPro; IPR022750; Interferon_reg_fac2-bd1_2_Znf.
DR   PANTHER; PTHR10816:SF18; INTERFERON REGULATORY FACTOR 2-BINDING PROTEIN 2; 1.
DR   PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR   Pfam; PF11261; IRF-2BP1_2; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..501
FT                   /note="Interferon regulatory factor 2-binding protein 2-B"
FT                   /id="PRO_0000328735"
FT   ZN_FING         420..467
FT                   /note="RING-type; degenerate"
FT   REGION          60..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          420..467
FT                   /note="Cys-rich"
FT   COMPBIAS        312..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  53711 MW;  281BBF549320859B CRC64;
     MSSAAVAASR RQSCYLCDLP RMPWAMIWDF TEPVCRGCVN YEGADRIEFV IETARQLKRA
     HGFQEGRSPG PVGKPGKDMQ SINHAEPGSR PPQPLDRYPL TSDRPPRLGA EYQRQANGIP
     VPNGFPKPDE PPELNRQSPN PRRTGAIPPN LVPLVNGSMP PVHALNGRSV QMGIPPGALA
     EHVGKRADDM KDKHRADSMS DPSDGHKRVD EWTQKGKTVR EMMTLQTLDS RFKKEHAALP
     HRMSYESSSG ALKTDRGKHS RGIKRKTSPE PDGEGIAVKL NGEGQPWLPS PSEVLKMPSA
     ALPGFAAAPP STISPHSRTT PPEAATAVQN SQSPMAALIL AADNAGTGSP KDAGNQVHST
     TTSAAGRRNS GSPQSPSAGQ RRPALGATGT AHIPGMDPQA GHPHSIPDSS VPPSSVPLCC
     TLCHERLEDT HFVQCPSVPS HKFCFPCSRE SIKQQGATGE VYCPSGEKCP LVGSNVPWAF
     MQGEIATILA GDVKVKKERD P
//