ID Q7TR63_MOUSE Unreviewed; 313 AA.
AC Q7TR63;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 166.
DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN Name=Or8k3b {ECO:0000313|Ensembl:ENSMUSP00000097462.2,
GN ECO:0000313|MGI:MGI:3030921};
GN Synonyms=Olfr1087 {ECO:0000313|EMBL:AAP71515.1,
GN ECO:0000313|MGI:MGI:3030921};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAP71515.1};
RN [1] {ECO:0000313|EMBL:AAP71515.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [2] {ECO:0000313|EMBL:AAP71515.1}
RP NUCLEOTIDE SEQUENCE.
RA Sanders K.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000097462.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097462.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000097462.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097462.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363047};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AY318283; AAP71515.1; -; Genomic_DNA.
DR RefSeq; NP_667057.2; NM_146846.2.
DR STRING; 10090.ENSMUSP00000149439; -.
DR PaxDb; 10090-ENSMUSP00000097462; -.
DR DNASU; 258843; -.
DR Ensembl; ENSMUST00000099877.2; ENSMUSP00000097462.2; ENSMUSG00000075174.3.
DR Ensembl; ENSMUST00000214141.2; ENSMUSP00000149439.2; ENSMUSG00000075174.3.
DR GeneID; 258843; -.
DR KEGG; mmu:258843; -.
DR UCSC; uc008kmu.1; mouse.
DR AGR; MGI:3030921; -.
DR CTD; 258843; -.
DR MGI; MGI:3030921; Or8k3b.
DR VEuPathDB; HostDB:ENSMUSG00000075174; -.
DR eggNOG; ENOG502SHX8; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR OMA; LMFINSE; -.
DR OrthoDB; 4632697at2759; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258843; 2 hits in 70 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 2.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR CDD; cd15413; 7tmA_OR8K-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48018:SF28; OLFACTORY RECEPTOR 8K3; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU363047};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047};
KW Olfaction {ECO:0000256|ARBA:ARBA00022725, ECO:0000256|RuleBase:RU363047};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU363047};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363047}.
FT TRANSMEM 27..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 91..115
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 149..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 198..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 237..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT DOMAIN 41..290
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 313 AA; 35371 MW; DEEB08E6AB967E8D CRC64;
MEKNNLTAVT QFILMGITER PELQAPLFGL FLVIYLSSMF GNLGMIILTT VDSKLQTPMY
FFIRHLAITD LGYSTAVGPK MLVNFVVDLN IISYNLCATQ LAFFLVFIIS ELLILSAMSY
DRYVAICKPL LYTVIMSQRV CQVLVAIPYL YCTFVSLLVT IKIFTLSFCG YNVISHFYCD
SLPLLSLICS NTNEIEMIIL VLAAFNLISS LLVVLVSYLF ILIAILRMNS AEGRRKAFST
CGSHLTVVTV FYGTLIFMYV QPQSSHSFDT DKVASIFYTL IIPMLNPMIY SLRNKDVKYA
LQRSLKKIYS ILS
//
