ID Q7TRU8_MOUSE Unreviewed; 323 AA.
AC Q7TRU8;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE SubName: Full=Olfactory receptor Olfr503 {ECO:0000313|EMBL:AAP71002.1};
DE SubName: Full=Olfactory receptor family 52 subfamily N member 4B {ECO:0000313|Ensembl:ENSMUSP00000077296.4};
GN Name=Or52n4b {ECO:0000313|Ensembl:ENSMUSP00000077296.4,
GN ECO:0000313|MGI:MGI:3030337};
GN Synonyms=Olfr503 {ECO:0000313|EMBL:AAP71002.1,
GN ECO:0000313|MGI:MGI:3030337};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAP71002.1};
RN [1] {ECO:0000313|EMBL:AAP71002.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [2] {ECO:0000313|EMBL:AAP71002.1}
RP NUCLEOTIDE SEQUENCE.
RA Sanders K.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000077296.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077296.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000077296.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077296.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AY317611; AAP71002.1; -; Genomic_DNA.
DR RefSeq; NP_001011527.1; NM_001011527.1.
DR STRING; 10090.ENSMUSP00000077296; -.
DR PaxDb; 10090-ENSMUSP00000077296; -.
DR Ensembl; ENSMUST00000078162.4; ENSMUSP00000077296.4; ENSMUSG00000060759.5.
DR GeneID; 259143; -.
DR KEGG; mmu:259143; -.
DR UCSC; uc009jcn.1; mouse.
DR AGR; MGI:3030337; -.
DR CTD; 259143; -.
DR MGI; MGI:3030337; Or52n4b.
DR VEuPathDB; HostDB:ENSMUSG00000060759; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR GeneTree; ENSGT01100000263528; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR OMA; WFHFKEI; -.
DR OrthoDB; 4578140at2759; -.
DR TreeFam; TF343679; -.
DR BioGRID-ORCS; 259143; 0 hits in 40 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000060759; Expressed in epiblast cell in embryo.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26450:SF194; OLFACTORY RECEPTOR 52N4; 1.
DR PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAP71002.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..297
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 323 AA; 36133 MW; 7A205E4E86D00C1D CRC64;
MVMSARNNPD LTPASFVLNG IPGLEHMHIW ISFPFCSMYA VAMMGNCGLL YLIFFEDSLH
RPMYYFLAML SLTDLVMCSS TIPKALCIFW FHLKEIGFDD CLVQMFFIHT FMGMESGVLM
LMALDHYVAI CYPLHYSTIL TNPIIAKIGL ATFLRGVLLI IPFIFLSKCL PYFRGNIINH
TYCDHMSVAK LPCGNVKVNA IYGLMVALLI GGFDILCITI SYIMILRAVV SLSSADARQK
AFSTCTAHIC AIVFSYSPTF LSFFSHHFGG HTIPPSCHII VANIYLLLPP TMNPVVYGVK
TKQIQDCVIR IFSESKDSKA HGI
//
