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Database: UniProt
Entry: Q7UFR2
LinkDB: Q7UFR2
Original site: Q7UFR2 
ID   UVRB_RHOBA              Reviewed;         708 AA.
AC   Q7UFR2;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   31-JUL-2019, entry version 95.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204}; OrderedLocusNames=RB8397;
OS   Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC   Bacteria; Planctomycetes; Planctomycetia; Planctomycetales;
OC   Planctomycetaceae; Rhodopirellula.
OX   NCBI_TaxID=243090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX   PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA   Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T.,
RA   Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R.,
RA   Schlesner H., Amann R., Reinhardt R.;
RT   "Complete genome sequence of the marine planctomycete Pirellula sp.
RT   strain 1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; BX294147; CAD78620.1; -; Genomic_DNA.
DR   RefSeq; NP_868342.1; NC_005027.1.
DR   RefSeq; WP_007329492.1; NC_005027.1.
DR   SMR; Q7UFR2; -.
DR   STRING; 243090.RB8397; -.
DR   EnsemblBacteria; CAD78620; CAD78620; RB8397.
DR   GeneID; 1796164; -.
DR   KEGG; rba:RB8397; -.
DR   PATRIC; fig|243090.15.peg.4045; -.
DR   eggNOG; ENOG4105CCW; Bacteria.
DR   eggNOG; COG0556; LUCA.
DR   HOGENOM; HOG000073580; -.
DR   InParanoid; Q7UFR2; -.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   OrthoDB; 95696at2; -.
DR   BioCyc; RBAL243090:RB8397-MONOMER; -.
DR   Proteomes; UP000001025; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    708       UvrABC system protein B.
FT                                /FTId=PRO_0000226040.
FT   DOMAIN       32    419       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      436    598       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      627    662       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      45     52       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF        98    121       Beta-hairpin.
SQ   SEQUENCE   708 AA;  80351 MW;  0A9DB5436BBCAABB CRC64;
     MSITKLAPAA FDLHQPFPPS GDQPAAIAKL IEGIQSGKTA QTLLGATGTG KTYTMANVIA
     SVQRPALILS HNKTLAAQLY GEFKEFFPNN AVHYFVSYYD YYQPEAYIPQ RDVYIEKDSS
     INEEIDRLRL ATTSSLVSRR DVVIVASVSS IYGLGSPDDY RQLVVDLHQG EQTRRDHLLL
     KFVDLQYQRN DIQFERGKFR VRGDSIELWP SYEEFAYRIE MWGDEIEKIS LIKPTSGETI
     KTVEHLYIYP CKHFVMPEDR IQRAIRLLRE ELTQQLEIFQ SQGKLLEAQR LSARTKFDLE
     MLAEVGHCPG IENYSRPLSG KEPGATPDTL YDFFPKDFIT FVDESHVTVP QVRAMYAGDR
     SRKITLVEHG FRLPCALDNR PLKFDEWEER TGQICFVSAT PSDYELERTG GEVVEQIIRP
     TGLLDPEVEI VSARGQVTHL LEQVRIRAER DERVLVTALT KRLAEDLATY FQEQGVKCRW
     LHSELNAFER VDLLQELRAG QFDCLVGVNL LREGLDLPEV SLVAILDADK EGFLRSETSL
     IQTIGRAARN ANSRVILYAD KVTDSMQMAI DETERRRVIQ MEYNAKHGIV PKTVRKSIRK
     GIDTEAANHK ESTRKAQDSG EAIYITIEYV DKLEQEMLAA AEDLEFERAA RLRDRVLQLK
     EHIGKPLSEV EIVDEKSAGK SGGRGRGRRG AKKKGASKGT KIPRPKRG
//
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