ID Q7UK97_RHOBA Unreviewed; 507 AA.
AC Q7UK97;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=hsdM {ECO:0000313|EMBL:CAD76984.1};
GN OrderedLocusNames=RB10768 {ECO:0000313|EMBL:CAD76984.1};
OS Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC Bacteria; Planctomycetota; Planctomycetia; Pirellulales; Pirellulaceae;
OC Rhodopirellula.
OX NCBI_TaxID=243090 {ECO:0000313|EMBL:CAD76984.1, ECO:0000313|Proteomes:UP000001025};
RN [1] {ECO:0000313|EMBL:CAD76984.1, ECO:0000313|Proteomes:UP000001025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10527 / NCIMB 13988 / SH1
RC {ECO:0000313|Proteomes:UP000001025};
RX PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA Reinhardt R.;
RT "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT 1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; BX294152; CAD76984.1; -; Genomic_DNA.
DR RefSeq; NP_869606.1; NC_005027.1.
DR RefSeq; WP_011122925.1; NC_005027.1.
DR AlphaFoldDB; Q7UK97; -.
DR STRING; 243090.RB10768; -.
DR REBASE; 7229; M.RbaORF10768P.
DR EnsemblBacteria; CAD76984; CAD76984; RB10768.
DR KEGG; rba:RB10768; -.
DR PATRIC; fig|243090.15.peg.5199; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_018284_2_0_0; -.
DR InParanoid; Q7UK97; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000001025; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF4; TYPE I RESTRICTION ENZYME ECOKI METHYLASE SUBUNIT; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CAD76984.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001025};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAD76984.1}.
FT DOMAIN 120..396
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 507 AA; 56055 MW; B787F0369BFA9853 CRC64;
MNTNDIVGKL WSLCHVLRDD GITYQDYVNE LSFLLFLKMM QETGQESELP DGYRWSDLES
KDGVEQLAFY RAMLVHLGTE GSPRVQSVFA DANTSLRQPK NLSKLVQDLD ELDWYVAREE
GLGDMYEGLL ERNASEKKSG AGQYFTPRPL IECMVNCMRP QPGEVIQDPA AGTGGFLIAA
HQYICNQTDD LFDLDADEQV FQKQQAYHAV ELVPDTHRLL VMNCMLHGVG GHLASGDSMG
SIGQNLPNAD VILTNPPFGT KRGGGKPTRD DFTFVTGNKQ LAFLQHIYRG LKPGGRAAVV
LPDNVLFEEG VGTRIRADLM DKCNLHTILR LPTGIFYAQG VKTNVLFFTR GKTDTGNTKQ
TWVYDLRTNM PAFGKRTPLT HGHFAEFEKC YGKKADGTSK RTEKTGGKKT CPALYEDDTV
HEGEESRFRV FSRDFVRERG DNLDISWLQD DSAGGSGSEL AEPDEIAAMI RERLGEALAE
MDALAELLEP ASLASSGSGG LGSEGRE
//
