ID MACB_RHOBA Reviewed; 684 AA.
AC Q7ULB5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=Macrolide export ATP-binding/permease protein MacB {ECO:0000255|HAMAP-Rule:MF_01720};
DE EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01720};
GN Name=macB {ECO:0000255|HAMAP-Rule:MF_01720}; OrderedLocusNames=RB9611;
OS Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC Bacteria; Planctomycetota; Planctomycetia; Pirellulales; Pirellulaceae;
OC Rhodopirellula.
OX NCBI_TaxID=243090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA Reinhardt R.;
RT "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT 1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC domains (TMD), which form a pore in the inner membrane, and an ATP-
CC binding domain (NBD), which is responsible for energy generation.
CC Confers resistance against macrolides. {ECO:0000255|HAMAP-
CC Rule:MF_01720}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01720}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01720}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC exporter (TC 3.A.1.122) family. {ECO:0000255|HAMAP-Rule:MF_01720}.
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DR EMBL; BX294149; CAD76362.1; -; Genomic_DNA.
DR RefSeq; NP_868977.1; NC_005027.1.
DR RefSeq; WP_011122387.1; NC_005027.1.
DR AlphaFoldDB; Q7ULB5; -.
DR SMR; Q7ULB5; -.
DR STRING; 243090.RB9611; -.
DR EnsemblBacteria; CAD76362; CAD76362; RB9611.
DR KEGG; rba:RB9611; -.
DR PATRIC; fig|243090.15.peg.4615; -.
DR eggNOG; COG0577; Bacteria.
DR eggNOG; COG1136; Bacteria.
DR HOGENOM; CLU_000604_78_2_0; -.
DR InParanoid; Q7ULB5; -.
DR OrthoDB; 9770099at2; -.
DR Proteomes; UP000001025; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR017911; MacB-like_ATP-bd.
DR InterPro; IPR025857; MacB_PCD.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR30572:SF4; MACROLIDE EXPORT ATP-BINDING_PERMEASE PROTEIN MACB; 1.
DR PANTHER; PTHR30572; MEMBRANE COMPONENT OF TRANSPORTER-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF12704; MacB_PCD; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51267; MACB; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; ATP-binding; Cell inner membrane; Cell membrane;
KW Membrane; Nucleotide-binding; Reference proteome; Translocase;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..684
FT /note="Macrolide export ATP-binding/permease protein MacB"
FT /id="PRO_0000269970"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT TRANSMEM 563..583
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT TRANSMEM 615..635
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT DOMAIN 2..243
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
SQ SEQUENCE 684 AA; 73964 MW; D9EAFE8C726D5087 CRC64;
MIQLYGLRKD YRVGDHDLPV LKGITLNIEA GEYVALMGSS GSGKTTLMNL LGSLDHPTDG
DYHLAGIDVS SLTPLELAAF RSQHIGFVFQ NFNLLPRATA LDNVMLPTIY ASDGRSRREC
IEDATKLLES VGLGGRLDHM PNQLSGGERQ RIAIARALMN RPKLLLADEP TGNLDTVTEQ
EILALFRQLN QEHGITLVVV THDAEVAHEA DRVVRMKDGL VAEDVRQRAS TVDRSRLANS
RAEPLREPAS AWSLPATWNA IVVAVLALRR NALRTVLTML GVIIGVASVI STMELSAGAS
TAIEETVASM GASMLTISPG KASSTSGRQR PIQIIPDDVV AVAEQCSAVK VAAPLVYSQV
QLVRQNRRWS PNLALGTTSQ YLAARNWDQL ELGTPFTQEQ VLDAAKVCIL GKTVAHELFD
SEYPIGEEIR VNGVPLRVVG VLTEKGGDVI GNDQDDIIIG PWTTFKLRVN SSTGATAQFS
TFADQMPPMQ LASTRRSTQR EEIHQIYVEA ESPDHVELAR QQITQVLSRR HNVEPAGAYR
INDITEVSKV VGQVVGGVSA LGLVIAGVSL MVGGVGIMNI MLVSVTERTR EIGLRMAVGA
NRSAILRQFL IEATVLCVVG GFIGIFAGHM WSVLVGRVIG WPTAMSIWAP IVAVTVAATV
GIVFGYYPAR TASRLNPIDA LRYE
//
