ID Q7VD05_PROMA Unreviewed; 521 AA.
AC Q7VD05;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=prolycopene isomerase {ECO:0000256|ARBA:ARBA00012419};
DE EC=5.2.1.13 {ECO:0000256|ARBA:ARBA00012419};
GN OrderedLocusNames=Pro_0584 {ECO:0000313|EMBL:AAP99629.1};
OS Prochlorococcus marinus (strain SARG / CCMP1375 / SS120).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=167539 {ECO:0000313|EMBL:AAP99629.1, ECO:0000313|Proteomes:UP000001420};
RN [1] {ECO:0000313|EMBL:AAP99629.1, ECO:0000313|Proteomes:UP000001420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SARG / CCMP1375 / SS120 {ECO:0000313|Proteomes:UP000001420};
RX PubMed=12917486; DOI=10.1073/pnas.1733211100;
RA Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M.,
RA Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S.,
RA Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J.,
RA Tandeau de Marsac N., Weissenbach J., Wincker P., Wolf Y.I., Hess W.R.;
RT "Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a
RT nearly minimal oxyphototrophic genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene;
CC Xref=Rhea:RHEA:30971, ChEBI:CHEBI:15948, ChEBI:CHEBI:62466;
CC EC=5.2.1.13; Evidence={ECO:0000256|ARBA:ARBA00000004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004900}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC {ECO:0000256|ARBA:ARBA00004258}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004258}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR EMBL; AE017126; AAP99629.1; -; Genomic_DNA.
DR RefSeq; NP_874977.1; NC_005042.1.
DR AlphaFoldDB; Q7VD05; -.
DR STRING; 167539.Pro_0584; -.
DR EnsemblBacteria; AAP99629; AAP99629; Pro_0584.
DR KEGG; pma:Pro_0584; -.
DR PATRIC; fig|167539.5.peg.599; -.
DR eggNOG; COG1233; Bacteria.
DR HOGENOM; CLU_019722_4_1_3; -.
DR OrthoDB; 416321at2; -.
DR Proteomes; UP000001420; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046608; F:carotenoid isomerase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR014101; CrtISO.
DR InterPro; IPR045892; CrtISO-like.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR NCBIfam; TIGR02730; carot_isom; 1.
DR PANTHER; PTHR46313; -; 1.
DR PANTHER; PTHR46313:SF3; PROLYCOPENE ISOMERASE, CHLOROPLASTIC; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Isomerase {ECO:0000313|EMBL:AAP99629.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000001420}.
FT DOMAIN 24..505
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 521 AA; 57542 MW; F8C6CEF6DD9DAAF1 CRC64;
MNLDKMRQNN KEISWDAIVI GSGIGGLVTA TQLASKGAQV LVLERYMIPG GSSGAFHRNG
YTFDVGASMI FGFGEKGYTN LLTRALSAIG EKCETIPDPV QLAYHLPGGA EVSVSRNYDQ
FISSLTSLFP HEEKGIKAFY KVCWEVFNCL DSMPLLSIED PAYLAKVFFK APLSCLGLAR
WLPFNVGEVA RRHIKDQQLL RFIDIECFCW SVMPADKTPM INAGMVFSDR HAGGINYPKG
GVGVISEKLV KGLEKNGGKV LYKSRVVKII LEGNKAIGVK LANGEQIYAR TIISNATRWD
TFGGEDVKEP LIEQSKTPSA ELKWRNRYQT SPSFLSIHLG VKKDCIPNDS HCHHLILEEW
DQMEKEQGVA FISIPTLLDQ SLAPKDHHII HAFTPSSIIE WKSLTPSEYV AKKELDCERL
LSKIEKVFPN LKPSITHKEI GTPKSHRRFL GRHKGSYGPI PAMRLPGLLP MPFNSTAIKG
LFLVGDSCFP GQGLNAVAFS GFACAHKIGA ELGINPWSLP E
//
