ID Q7VFA9_HELHP Unreviewed; 530 AA.
AC Q7VFA9;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=ATP-dependent RNA helicase DeaD {ECO:0000313|EMBL:AAP78365.1};
GN Name=deaD {ECO:0000313|EMBL:AAP78365.1};
GN OrderedLocusNames=HH_1768 {ECO:0000313|EMBL:AAP78365.1};
OS Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=235279 {ECO:0000313|EMBL:AAP78365.1, ECO:0000313|Proteomes:UP000002495};
RN [1] {ECO:0000313|EMBL:AAP78365.1, ECO:0000313|Proteomes:UP000002495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51449 / 3B1 {ECO:0000313|Proteomes:UP000002495};
RX PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA Shen Z., Weber J., Frosch M., Fox J.G.;
RT "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT hepaticus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
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DR EMBL; AE017125; AAP78365.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7VFA9; -.
DR STRING; 235279.HH_1768; -.
DR KEGG; hhe:HH_1768; -.
DR eggNOG; COG0513; Bacteria.
DR HOGENOM; CLU_003041_21_4_7; -.
DR Proteomes; UP000002495; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd00268; DEADc; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959:SF19; ATP-DEPENDENT RNA HELICASE DBPA; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AAP78365.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002495}.
FT DOMAIN 45..73
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 76..245
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 256..418
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 478..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 45..73
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 490..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 59601 MW; 4BC35E3FA1AD2BA7 CRC64;
MNNLGYLLNV KVKRMDNASL IQQSEESPSV TIKQGLKSKH KQDTQGFDVF GLKDFVLKGI
REAGFSTPSP VQSQSIPIIL QGKDLIAQAQ TGTGKTAAFA IPILNTLNRN KDIEALIITP
TRELAMQISE EILKLGRFGR IKTICMYGGQ SIKRQCDLLE KKPKAMIATP GRLLDHLQNG
RIAHFSPQIV VLDESDEMLD MGFLDDIEEI FKFLPNTRQT LLFSATMPEP IKALAMKILN
EPAFVKITPT DVTNQDIEQQ YYIINEGERD EAIVRLIETQ NPTKSIIFTR MKKEADALAI
RLANRGFKAI ALHGDMEQRD RREAIKAFRE NKIEILVATD VASRGLDISD VSHVFNYHIP
LNPESYVHRI GRTGRAGKKG VAVTLATPLE YKDLSKIKQI TKAKLKLCEI KQEYSDDAFS
QELSHTKISD KSVAIYEKLK DKIDTTQLCL KLISLHLEKN SSLKIGLSKE QIAKLEENYE
SEQPKKSNKK FVGNTRSATK GNLRGGKGSK NNKRYDNIDR SQPYTNSIWG
//
