ID Q7VJR9_HELHP Unreviewed; 1042 AA.
AC Q7VJR9;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Conserved hypothetical membrane protein {ECO:0000313|EMBL:AAP76771.1};
GN OrderedLocusNames=HH_0174 {ECO:0000313|EMBL:AAP76771.1};
OS Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=235279 {ECO:0000313|EMBL:AAP76771.1, ECO:0000313|Proteomes:UP000002495};
RN [1] {ECO:0000313|EMBL:AAP76771.1, ECO:0000313|Proteomes:UP000002495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51449 / 3B1 {ECO:0000313|Proteomes:UP000002495};
RX PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA Shen Z., Weber J., Frosch M., Fox J.G.;
RT "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT hepaticus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017125; AAP76771.1; -; Genomic_DNA.
DR RefSeq; WP_011115017.1; NC_004917.1.
DR AlphaFoldDB; Q7VJR9; -.
DR STRING; 235279.HH_0174; -.
DR GeneID; 82134805; -.
DR KEGG; hhe:HH_0174; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_7; -.
DR OrthoDB; 9759330at2; -.
DR Proteomes; UP000002495; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002495};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1042 AA; 113844 MW; 97B905DC588E7ADD CRC64;
MSRFCINRPI FAMVLSIVIT LVGCISMFVL PIEEYPQVVP NEIMVQATYS GASAEVMANT
VASIIEDSIN GVEGMLYMKS SSTSSGVMNL SVFFSNDTNA DMALVNVSNR VQAALAQLPT
EVQRVGITTR KRSSTMLGVY AMYSDNPAYT ATFVANYGIL NVINELKRVP GVGDVTPFGT
RDYSMRIWLD IDKLSQNNLT PSEVAKVIAE QNSQFAVGSF GKEPVRSDIA FTYSVTTQGR
FVSAEEFGNI IIRSNNDGSA LRLKDVAKIE LGAKDYSVSP LFNGKDAAAF GIALQPGANA
LDVADNVEKK MKELSQNFPE GLHYKNVYNT TDFVKISIKE VRKTFIEAIV LVVIIMYFFL
QNFRATIIPV IAIPVSIIGT FAGMYALGFS INLLTLFGLI LAIGIVVDDA IIVIENVERI
LHTETKANGE KYSVKEATLK AMGEIQGPVV AIVLVLCSVF IPVAFIGGFS GAIYKQFAIT
IVISVVISGF VALTLTPALC VSILKAKEPK PFYIVKRFND FFDWLTHKFG MQIGRALRRG
SALLLCFVAI IVVTWGLFSR LPSSLVPSED KGSMISFIQL PPAASLSRTT TEGKKALAIL
EQNPNVDYSF LISGFDMLAS AARSSGAVIF VTLKNWSERN ESSFEMSKKM MGVFNASLDA
FSLVTTPPAI MGLSTVGGFE IYIQDRNGGS IKDLEKYANL LVMEANKRKE LVGVRSLFSA
NIPQYHLTLD RERAKASNVN IDDVFTTMQS TFGQYYVNDF NLYGKTYQVN VQAQSEFRES
PEDLSRIFVK SGNGDLIPIS ALVHFERVIG PDIVDRFNLF TSAKIVGNPN ESEGYSSGDA
LRVIEQLVKE VLPEGYTIAY SGTSYQEKNA SGTGEIAFIF GLIFVFLILC AQYERWLMPL
SVLSAVPFAV FGAVVATTLR GLDNDIYFNI GLVMLIALSA KNAILIVEFA QHLHEKEGKG
IMESAIGAAK LRFRPIIMTS LAFSIGVLPL VLSTGAGSAA RHAIGTGVIG GMMAATFIAI
FFIPLFWSYI ARLSQWLKNK MS
//
