ID Q7VSG5_BORPE Unreviewed; 875 AA.
AC Q7VSG5;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 08-NOV-2023, entry version 124.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN Name=topB {ECO:0000313|EMBL:CAE44790.1};
GN OrderedLocusNames=BP0460 {ECO:0000313|EMBL:CAE44790.1};
OS Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=257313 {ECO:0000313|EMBL:CAE44790.1, ECO:0000313|Proteomes:UP000002676};
RN [1] {ECO:0000313|EMBL:CAE44790.1, ECO:0000313|Proteomes:UP000002676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251
RC {ECO:0000313|Proteomes:UP000002676};
RX PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; BX640412; CAE44790.1; -; Genomic_DNA.
DR RefSeq; NP_879317.1; NC_002929.2.
DR RefSeq; WP_010929817.1; NZ_CP039022.1.
DR AlphaFoldDB; Q7VSG5; -.
DR STRING; 257313.BP0460; -.
DR PaxDb; 257313-BP0460; -.
DR GeneID; 69600191; -.
DR KEGG; bpe:BP0460; -.
DR PATRIC; fig|257313.5.peg.499; -.
DR eggNOG; COG0550; Bacteria.
DR HOGENOM; CLU_002929_5_2_4; -.
DR OMA; GKWSFAN; -.
DR Proteomes; UP000002676; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 2.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CAE44790.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002676};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 3..135
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 811..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..875
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 96533 MW; 1F1861AAA840BE06 CRC64;
MNKTLIIAEK PSVALDISRA LGGFAREGDY FESDRYVLAS SIGHLLSLVA PNDPVKGKWS
FTHLPVIPPA FELGPTDKKS AERLKLLVRL AKRKDVDAII NACDAGREGE LIFRYIVQFA
GVKKPIQRLW LQSMTQQAIR DAFANLRDDE QLKPLEAAAR SRAEADWLVG INGTRAMTAF
NSKDGGFFKT PVGRVQTPTL AIVNERENRI RSFVSRDYWE VHATFVAAAG LYEGRWIDPA
FRKDERDPEK RESRLWSLAA AQSVVAACRA QSGSVTEESK PSTQMSPALY DLTSLQREAN
GRFGFSAKTT LALAQTLYER HKALTYPRTD SRYLPEDYIN TVRQTMQVLA QGDSNAVGAL
SRHADTVLAQ NWVKPNRRIF DNKKVSDHFA IIPTLQVPRD LSEAEGKLYD LVLKRFLAVF
FPAAEYRVTT RLTEVQGHRF KTEGKVLVTP GWLAVYGKEA QGEDANLVPV ADGETVRAED
VEAVGLATKP PARYNEATLL SAMEGAGKLV DDEELREAMS ERGLGTPATR AAIIEGLLNE
AYLRRDGRDL VPTAKARQLM ALLSGLDVSE LTSPELTGEW EHKLKQIEQG ALDRAAFMRE
IAQMTQVIVK RAKEYERDTV PGDYATLQTP CPKCGGVVKE NYRRFACTQC DFSIGKHPGG
RTFELPEVEE LLAKREIGPL QGCISKMGRP FAAILRISGE YKLEFDFGQN DEEDNEAVDF
SGHTPVGACP KCSARVFEHG MSYVCEKLVG LQKSCDFRSG KVILQQEISR EQMEKLLTAG
RTDLLDGFVS SRTNRKFKAF LVRQPDGKVG FEFEPRGDKP GRPGAAAKKA AGKTATKTAA
KAPAKTAAKK AVKKAAPKKA ATKTAAKKAA KKSAA
//