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Database: UniProt
Entry: Q7VSG5_BORPE
LinkDB: Q7VSG5_BORPE
Original site: Q7VSG5_BORPE 
ID   Q7VSG5_BORPE            Unreviewed;       875 AA.
AC   Q7VSG5;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   08-NOV-2023, entry version 124.
DE   RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE            EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE   AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE   AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE   AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE   AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN   Name=topB {ECO:0000313|EMBL:CAE44790.1};
GN   OrderedLocusNames=BP0460 {ECO:0000313|EMBL:CAE44790.1};
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313 {ECO:0000313|EMBL:CAE44790.1, ECO:0000313|Proteomes:UP000002676};
RN   [1] {ECO:0000313|EMBL:CAE44790.1, ECO:0000313|Proteomes:UP000002676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251
RC   {ECO:0000313|Proteomes:UP000002676};
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC         passage and rejoining.; EC=5.6.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000213};
CC   -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC       {ECO:0000256|ARBA:ARBA00009446}.
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DR   EMBL; BX640412; CAE44790.1; -; Genomic_DNA.
DR   RefSeq; NP_879317.1; NC_002929.2.
DR   RefSeq; WP_010929817.1; NZ_CP039022.1.
DR   AlphaFoldDB; Q7VSG5; -.
DR   STRING; 257313.BP0460; -.
DR   PaxDb; 257313-BP0460; -.
DR   GeneID; 69600191; -.
DR   KEGG; bpe:BP0460; -.
DR   PATRIC; fig|257313.5.peg.499; -.
DR   eggNOG; COG0550; Bacteria.
DR   HOGENOM; CLU_002929_5_2_4; -.
DR   OMA; GKWSFAN; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00186; TOP1Ac; 1.
DR   CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR   Gene3D; 3.40.50.140; -; 1.
DR   Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR   Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR   Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR003601; Topo_IA_2.
DR   InterPro; IPR023406; Topo_IA_AS.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR013826; Topo_IA_cen_sub3.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR   InterPro; IPR005738; TopoIII.
DR   InterPro; IPR025589; Toprim_C_rpt.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR034144; TOPRIM_TopoIII.
DR   NCBIfam; TIGR01056; topB; 1.
DR   PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR   PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   Pfam; PF13342; Toprim_Crpt; 2.
DR   PRINTS; PR00417; PRTPISMRASEI.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SMART; SM00436; TOP1Bc; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR   PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CAE44790.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002676};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          3..135
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   REGION          811..875
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        847..875
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   875 AA;  96533 MW;  1F1861AAA840BE06 CRC64;
     MNKTLIIAEK PSVALDISRA LGGFAREGDY FESDRYVLAS SIGHLLSLVA PNDPVKGKWS
     FTHLPVIPPA FELGPTDKKS AERLKLLVRL AKRKDVDAII NACDAGREGE LIFRYIVQFA
     GVKKPIQRLW LQSMTQQAIR DAFANLRDDE QLKPLEAAAR SRAEADWLVG INGTRAMTAF
     NSKDGGFFKT PVGRVQTPTL AIVNERENRI RSFVSRDYWE VHATFVAAAG LYEGRWIDPA
     FRKDERDPEK RESRLWSLAA AQSVVAACRA QSGSVTEESK PSTQMSPALY DLTSLQREAN
     GRFGFSAKTT LALAQTLYER HKALTYPRTD SRYLPEDYIN TVRQTMQVLA QGDSNAVGAL
     SRHADTVLAQ NWVKPNRRIF DNKKVSDHFA IIPTLQVPRD LSEAEGKLYD LVLKRFLAVF
     FPAAEYRVTT RLTEVQGHRF KTEGKVLVTP GWLAVYGKEA QGEDANLVPV ADGETVRAED
     VEAVGLATKP PARYNEATLL SAMEGAGKLV DDEELREAMS ERGLGTPATR AAIIEGLLNE
     AYLRRDGRDL VPTAKARQLM ALLSGLDVSE LTSPELTGEW EHKLKQIEQG ALDRAAFMRE
     IAQMTQVIVK RAKEYERDTV PGDYATLQTP CPKCGGVVKE NYRRFACTQC DFSIGKHPGG
     RTFELPEVEE LLAKREIGPL QGCISKMGRP FAAILRISGE YKLEFDFGQN DEEDNEAVDF
     SGHTPVGACP KCSARVFEHG MSYVCEKLVG LQKSCDFRSG KVILQQEISR EQMEKLLTAG
     RTDLLDGFVS SRTNRKFKAF LVRQPDGKVG FEFEPRGDKP GRPGAAAKKA AGKTATKTAA
     KAPAKTAAKK AVKKAAPKKA ATKTAAKKAA KKSAA
//
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