ID ICOS_CANLF Reviewed; 208 AA.
AC Q7YR73;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Inducible T-cell costimulator;
DE AltName: Full=Activation-inducible lymphocyte immunomediatory molecule;
DE AltName: CD_antigen=CD278;
DE Flags: Precursor;
GN Name=ICOS; Synonyms=AILIM;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lee J.-H., Kuhr C., Storb R.;
RT "Cloning and characterization of canine ICOS gene.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Enhances all basic T-cell responses to a foreign antigen,
CC namely proliferation, secretion of lymphokines, up-regulation of
CC molecules that mediate cell-cell interaction, and effective help for
CC antibody secretion by B-cells. Essential both for efficient interaction
CC between T and B-cells and for normal antibody responses to T-cell
CC dependent antigens. Does not up-regulate the production of interleukin-
CC 2, but superinduces the synthesis of interleukin-10. Prevents the
CC apoptosis of pre-activated T-cells. Plays a critical role in CD40-
CC mediated class switching of immunoglobin isotypes (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY342349; AAQ20845.1; -; mRNA.
DR RefSeq; NP_001002972.1; NM_001002972.2.
DR AlphaFoldDB; Q7YR73; -.
DR SMR; Q7YR73; -.
DR STRING; 9615.ENSCAFP00000018974; -.
DR GlyCosmos; Q7YR73; 2 sites, No reported glycans.
DR PaxDb; 9612-ENSCAFP00000018974; -.
DR Ensembl; ENSCAFT00000105814.1; ENSCAFP00000070678.1; ENSCAFG00000012880.6.
DR Ensembl; ENSCAFT00030041709.1; ENSCAFP00030036390.1; ENSCAFG00030022677.1.
DR Ensembl; ENSCAFT00040047502.1; ENSCAFP00040041463.1; ENSCAFG00040025457.1.
DR Ensembl; ENSCAFT00805032042; ENSCAFP00805025157; ENSCAFG00805017657.
DR Ensembl; ENSCAFT00845032572.1; ENSCAFP00845025476.1; ENSCAFG00845018403.1.
DR GeneID; 403456; -.
DR KEGG; cfa:403456; -.
DR CTD; 29851; -.
DR VEuPathDB; HostDB:ENSCAFG00845018403; -.
DR VGNC; VGNC:41861; ICOS.
DR eggNOG; ENOG502S59F; Eukaryota.
DR GeneTree; ENSGT00390000000801; -.
DR HOGENOM; CLU_1315009_0_0_1; -.
DR InParanoid; Q7YR73; -.
DR OMA; QDKEDCF; -.
DR OrthoDB; 4570780at2759; -.
DR TreeFam; TF335679; -.
DR Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-CFA-388841; Costimulation by the CD28 family.
DR Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Proteomes; UP000002254; Chromosome 37.
DR Proteomes; UP000694429; Chromosome 37.
DR Proteomes; UP000694542; Chromosome 37.
DR Proteomes; UP000805418; Chromosome 37.
DR Bgee; ENSCAFG00000012880; Expressed in blood and 33 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0031295; P:T cell costimulation; IBA:GO_Central.
DR GO; GO:0002517; P:T cell tolerance induction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR039943; ICOS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR20904:SF0; INDUCIBLE T-CELL COSTIMULATOR; 1.
DR PANTHER; PTHR20904; INDUCIBLE T-CELL COSTIMULATOR ICOS; 1.
DR Pfam; PF15910; V-set_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..208
FT /note="Inducible T-cell costimulator"
FT /id="PRO_0000014805"
FT TOPO_DOM 20..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..132
FT /note="Ig-like V-type"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 42..108
FT /evidence="ECO:0000250"
FT DISULFID 63..82
FT /evidence="ECO:0000250"
SQ SEQUENCE 208 AA; 23587 MW; 8BAB95D1A07FAC7E CRC64;
MKSDLWYFLL FCFQVEALTG EINDSTKSEM FTFHDGGVQI LCKFNAIVSQ YKMELLKGTE
VLCDLTTTKE NGNTVSKNPK FCQSQSSSDG VSFFLYNLDS SHASYYACQL SIFDPPPFQR
KNISREYLNV YESQTCCQLK FWLPIGCAAF VVVYIFGCIF LCWLTKKKYR SSVHDPNSEY
MFMAAVNTAK KPGLTGVTHN LELCGTQA
//
