ID Q7Z138_CAEEL Unreviewed; 330 AA.
AC Q7Z138;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 2.
DT 24-JAN-2024, entry version 145.
DE SubName: Full=Aquaporin-9 {ECO:0000313|EMBL:CCD68565.2};
GN Name=aqp-8 {ECO:0000313|EMBL:CCD68565.2,
GN ECO:0000313|WormBase:K02G10.7a};
GN ORFNames=CELE_K02G10.7 {ECO:0000313|EMBL:CCD68565.2}, K02G10.7
GN {ECO:0000313|WormBase:K02G10.7a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD68565.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD68565.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68565.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR EMBL; BX284606; CCD68565.2; -; Genomic_DNA.
DR RefSeq; NP_001024757.1; NM_001029586.4.
DR AlphaFoldDB; Q7Z138; -.
DR SMR; Q7Z138; -.
DR EPD; Q7Z138; -.
DR EnsemblMetazoa; K02G10.7a.1; K02G10.7a.1; WBGene00000176.
DR UCSC; K02G10.7a; c. elegans.
DR AGR; WB:WBGene00000176; -.
DR WormBase; K02G10.7a; CE53162; WBGene00000176; aqp-8.
DR HOGENOM; CLU_020019_9_1_1; -.
DR InParanoid; Q7Z138; -.
DR OrthoDB; 2875289at2759; -.
DR Reactome; R-CEL-432030; Transport of glycerol from adipocytes to the liver by Aquaporins.
DR Reactome; R-CEL-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-CEL-432047; Passive transport by Aquaporins.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00000176; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; Q7Z138; baseline and differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0009986; C:cell surface; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015254; F:glycerol channel activity; IBA:GO_Central.
DR GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR GO; GO:0015793; P:glycerol transmembrane transport; IBA:GO_Central.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR NCBIfam; TIGR00861; MIP; 1.
DR PANTHER; PTHR43829; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR PANTHER; PTHR43829:SF4; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000477};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT TRANSMEM 23..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 330 AA; 35404 MW; AAA6D63160E6DA09 CRC64;
MGVFQDKVAS ILRIEDQQFT RELLAECIGT FFLLLIGNAA NIQAAVAVGG NSTSCHIAWG
IGFMFAVYLA ASVSGGHLNP AISVAQSILG NLPPWKIIPY AIAQVIGAFL GAAVAYFGHH
DDLWKLDGGI RQVTGGQATA GLFTTFPPDH MSVWGSLLDQ IIGTAMLSGL VCLITDKRHQ
IPTGVVPVLA GSIMSMVAMT FGANGGFAIN PARDFGPRVF CLCAGYGWEV FSAHGYYFWI
PIVGALIGSI IGAWIYKIFV GLHGMNESLD IQPAKGFNEM QRNSEGILIG YDNTLSRARG
GEIAAPRTYT PSYQVFESSR TQITTADRRY
//