GenomeNet

Database: UniProt
Entry: Q7Z3S9
LinkDB: Q7Z3S9
Original site: Q7Z3S9 
ID   NT2NA_HUMAN             Reviewed;         236 AA.
AC   Q7Z3S9; Q5BKT8; Q5VTG9; Q5XG84; Q6P192; Q8NC23; Q8WUQ9; Q96FY1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   10-APR-2019, entry version 157.
DE   RecName: Full=Notch homolog 2 N-terminal-like protein A {ECO:0000303|PubMed:29856954, ECO:0000303|PubMed:29856955};
DE   AltName: Full=Notch homolog 2 N-terminal-like protein {ECO:0000303|PubMed:14673143};
GN   Name=NOTCH2NLA {ECO:0000303|PubMed:29856954,
GN   ECO:0000303|PubMed:29856955, ECO:0000312|HGNC:HGNC:31862};
GN   Synonyms=N2N {ECO:0000303|PubMed:14673143},
GN   NOTCH2NL {ECO:0000312|HGNC:HGNC:31862};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Retina;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP   ILE-158.
RC   TISSUE=Brain, Eye, Liver, Ovary, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   INTERACTION WITH ELANE, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING
RP   BY ELANE, AND TISSUE SPECIFICITY.
RX   PubMed=14673143; DOI=10.1128/MCB.24.1.58-70.2004;
RA   Duan Z., Li F.-Q., Wechsler J., Meade-White K., Williams K.,
RA   Benson K.F., Horwitz M.;
RT   "A novel notch protein, N2N, targeted by neutrophil elastase and
RT   implicated in hereditary neutropenia.";
RL   Mol. Cell. Biol. 24:58-70(2004).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NOTCH2, TISSUE
RP   SPECIFICITY, AND INVOLVEMENT IN CHROMOSOME 1Q21.1 DELETION/DUPLICATION
RP   SYNDROME.
RX   PubMed=29856954; DOI=10.1016/j.cell.2018.03.051;
RA   Fiddes I.T., Lodewijk G.A., Mooring M., Bosworth C.M., Ewing A.D.,
RA   Mantalas G.L., Novak A.M., van den Bout A., Bishara A.,
RA   Rosenkrantz J.L., Lorig-Roach R., Field A.R., Haeussler M., Russo L.,
RA   Bhaduri A., Nowakowski T.J., Pollen A.A., Dougherty M.L., Nuttle X.,
RA   Addor M.C., Zwolinski S., Katzman S., Kriegstein A., Eichler E.E.,
RA   Salama S.R., Jacobs F.M.J., Haussler D.;
RT   "Human-specific NOTCH2NL genes affect Notch signaling and cortical
RT   neurogenesis.";
RL   Cell 173:1356-1369(2018).
RN   [7]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=29856955; DOI=10.1016/j.cell.2018.03.067;
RA   Suzuki I.K., Gacquer D., Van Heurck R., Kumar D., Wojno M., Bilheu A.,
RA   Herpoel A., Lambert N., Cheron J., Polleux F., Detours V.,
RA   Vanderhaeghen P.;
RT   "Human-specific NOTCH2NL genes expand cortical neurogenesis through
RT   Delta/Notch regulation.";
RL   Cell 173:1370-1384(2018).
RN   [8]
RP   FUNCTION.
RX   PubMed=29561261; DOI=10.7554/eLife.32332;
RA   Florio M., Heide M., Pinson A., Brandl H., Albert M., Winkler S.,
RA   Wimberger P., Huttner W.B., Hiller M.;
RT   "Evolution and cell-type specificity of human-specific genes
RT   preferentially expressed in progenitors of fetal neocortex.";
RL   Elife 7:0-0(2018).
CC   -!- FUNCTION: Human-specific protein that promotes neural progenitor
CC       proliferation and evolutionary expansion of the brain neocortex by
CC       regulating the Notch signaling pathway (PubMed:29856954,
CC       PubMed:29856955, PubMed:29561261). Able to promote neural
CC       progenitor self-renewal, possibly by down-regulating neuronal
CC       differentiation genes, thereby delaying the differentiation of
CC       neuronal progenitors and leading to an overall final increase in
CC       neuronal production (PubMed:29856954). Acts by enhancing the Notch
CC       signaling pathway via two different mechanisms that probably work
CC       in parallel to reach the same effect (PubMed:29856954). Enhances
CC       Notch signaling pathway in a non-cell-autonomous manner via direct
CC       interaction with NOTCH2 (PubMed:29856954). Also promotes Notch
CC       signaling pathway in a cell-autonomous manner through inhibition
CC       of cis DLL1-NOTCH2 interactions, which promotes neuronal
CC       differentiation (By similarity). {ECO:0000250|UniProtKB:P0DPK3,
CC       ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954,
CC       ECO:0000269|PubMed:29856955}.
CC   -!- SUBUNIT: Interacts with ELANE (PubMed:14673143). Interacts with
CC       NOTCH2 (PubMed:29856954). Interacts with DLL1; the interaction is
CC       direct (By similarity). {ECO:0000250|UniProtKB:P0DPK3,
CC       ECO:0000269|PubMed:14673143, ECO:0000269|PubMed:29856954}.
CC   -!- INTERACTION:
CC       Q5BKY6:-; NbExp=3; IntAct=EBI-945833, EBI-10243533;
CC       Q9NWL9:-; NbExp=3; IntAct=EBI-945833, EBI-10315054;
CC       Q96HD9:ACY3; NbExp=3; IntAct=EBI-945833, EBI-3916242;
CC       P82987:ADAMTSL3; NbExp=3; IntAct=EBI-945833, EBI-10221726;
CC       Q6ZMM2-2:ADAMTSL5; NbExp=3; IntAct=EBI-945833, EBI-10254938;
CC       Q3MIX3:ADCK5; NbExp=3; IntAct=EBI-945833, EBI-3923548;
CC       Q08117:AES; NbExp=3; IntAct=EBI-945833, EBI-717810;
CC       P43353:ALDH3B1; NbExp=3; IntAct=EBI-945833, EBI-2558314;
CC       P09923:ALPI; NbExp=3; IntAct=EBI-945833, EBI-1052631;
CC       P29972:AQP1; NbExp=5; IntAct=EBI-945833, EBI-745213;
CC       P55064:AQP5; NbExp=3; IntAct=EBI-945833, EBI-746103;
CC       Q99856:ARID3A; NbExp=3; IntAct=EBI-945833, EBI-5458244;
CC       Q9BZE9:ASPSCR1; NbExp=3; IntAct=EBI-945833, EBI-1993677;
CC       Q7Z3C6:ATG9A; NbExp=3; IntAct=EBI-945833, EBI-727146;
CC       A8KA13:BCL6B; NbExp=3; IntAct=EBI-945833, EBI-10174813;
CC       P62952:BLCAP; NbExp=3; IntAct=EBI-945833, EBI-3895726;
CC       A8K571:BMP7; NbExp=3; IntAct=EBI-945833, EBI-10174327;
CC       Q6NUJ2:C11orf87; NbExp=3; IntAct=EBI-945833, EBI-6660291;
CC       A6NFR6-4:C5orf60; NbExp=3; IntAct=EBI-945833, EBI-10173955;
CC       Q8N4G4:CA6; NbExp=3; IntAct=EBI-945833, EBI-10265475;
CC       Q9Y2V2:CARHSP1; NbExp=5; IntAct=EBI-945833, EBI-718719;
CC       Q8NEC5:CATSPER1; NbExp=5; IntAct=EBI-945833, EBI-744545;
CC       Q8TAB7:CCDC26; NbExp=3; IntAct=EBI-945833, EBI-10271580;
CC       Q8TC90:CCER1; NbExp=5; IntAct=EBI-945833, EBI-746041;
CC       Q04900:CD164; NbExp=5; IntAct=EBI-945833, EBI-2115896;
CC       Q8N619:CDK5R1; NbExp=3; IntAct=EBI-945833, EBI-10266998;
CC       Q8TAM4:CDK5R1; NbExp=3; IntAct=EBI-945833, EBI-10271838;
CC       Q8TCT0:CERK; NbExp=5; IntAct=EBI-945833, EBI-10274247;
CC       Q9NX63:CHCHD3; NbExp=5; IntAct=EBI-945833, EBI-743375;
CC       Q8NE62:CHDH; NbExp=3; IntAct=EBI-945833, EBI-7127986;
CC       Q9UKJ5:CHIC2; NbExp=5; IntAct=EBI-945833, EBI-741528;
CC       Q9H2X0:CHRD; NbExp=5; IntAct=EBI-945833, EBI-947551;
CC       P07510:CHRNG; NbExp=3; IntAct=EBI-945833, EBI-9008836;
CC       P07510-2:CHRNG; NbExp=5; IntAct=EBI-945833, EBI-11979451;
CC       P57739:CLDN2; NbExp=3; IntAct=EBI-945833, EBI-751440;
CC       A5D8T8:CLEC18A; NbExp=3; IntAct=EBI-945833, EBI-10173491;
CC       P27658:COL8A1; NbExp=5; IntAct=EBI-945833, EBI-747133;
CC       Q9BSW2:CRACR2A; NbExp=3; IntAct=EBI-945833, EBI-739773;
CC       Q9UGL9:CRCT1; NbExp=3; IntAct=EBI-945833, EBI-713677;
CC       Q02930-3:CREB5; NbExp=5; IntAct=EBI-945833, EBI-10192698;
CC       P09603:CSF1; NbExp=3; IntAct=EBI-945833, EBI-2872294;
CC       P09228:CST2; NbExp=5; IntAct=EBI-945833, EBI-8832659;
CC       Q9H4G1:CST9L; NbExp=5; IntAct=EBI-945833, EBI-3923092;
CC       P08311:CTSG; NbExp=3; IntAct=EBI-945833, EBI-5462635;
CC       Q9UBR2:CTSZ; NbExp=5; IntAct=EBI-945833, EBI-8636823;
CC       Q6I9S7:CXCL5; NbExp=3; IntAct=EBI-945833, EBI-10249885;
CC       Q96LJ7:DHRS1; NbExp=5; IntAct=EBI-945833, EBI-746300;
CC       Q9NQL9:DMRT3; NbExp=5; IntAct=EBI-945833, EBI-9679045;
CC       O96015:DNAL4; NbExp=3; IntAct=EBI-945833, EBI-742362;
CC       Q92608:DOCK2; NbExp=5; IntAct=EBI-945833, EBI-448771;
CC       P52797:EFNA3; NbExp=3; IntAct=EBI-945833, EBI-722730;
CC       O60573:EIF4E2; NbExp=3; IntAct=EBI-945833, EBI-398610;
CC       O15197-2:EPHB6; NbExp=3; IntAct=EBI-945833, EBI-10182490;
CC       O00519:FAAH; NbExp=3; IntAct=EBI-945833, EBI-1389829;
CC       Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-945833, EBI-741626;
CC       Q8NEG0:FAM71C; NbExp=5; IntAct=EBI-945833, EBI-752049;
CC       Q5TZK3:FAM74A6; NbExp=5; IntAct=EBI-945833, EBI-10247271;
CC       O95363:FARS2; NbExp=3; IntAct=EBI-945833, EBI-2513774;
CC       P48023:FASLG; NbExp=3; IntAct=EBI-945833, EBI-495538;
CC       Q96D16:FBXL18; NbExp=3; IntAct=EBI-945833, EBI-744419;
CC       Q969U6:FBXW5; NbExp=5; IntAct=EBI-945833, EBI-741068;
CC       Q99853:FOXB1; NbExp=3; IntAct=EBI-945833, EBI-3916225;
CC       O43559:FRS3; NbExp=5; IntAct=EBI-945833, EBI-725515;
CC       O14764:GABRD; NbExp=3; IntAct=EBI-945833, EBI-744352;
CC       P23769:GATA2; NbExp=3; IntAct=EBI-945833, EBI-2806671;
CC       P55040:GEM; NbExp=3; IntAct=EBI-945833, EBI-744104;
CC       Q9NXC2:GFOD1; NbExp=3; IntAct=EBI-945833, EBI-8799578;
CC       P09681:GIP; NbExp=3; IntAct=EBI-945833, EBI-8588553;
CC       P43220:GLP1R; NbExp=5; IntAct=EBI-945833, EBI-7466542;
CC       O76003:GLRX3; NbExp=3; IntAct=EBI-945833, EBI-374781;
CC       Q6IB77:GLYAT; NbExp=3; IntAct=EBI-945833, EBI-715463;
CC       P04899:GNAI2; NbExp=3; IntAct=EBI-945833, EBI-353997;
CC       Q9Y223:GNE; NbExp=3; IntAct=EBI-945833, EBI-4291090;
CC       P09211:GSTP1; NbExp=5; IntAct=EBI-945833, EBI-353467;
CC       Q9Y5Q8:GTF3C5; NbExp=3; IntAct=EBI-945833, EBI-1045409;
CC       P02008:HBZ; NbExp=5; IntAct=EBI-945833, EBI-719843;
CC       P08631:HCK; NbExp=3; IntAct=EBI-945833, EBI-346340;
CC       V9HW60:HEL-S-182mP; NbExp=3; IntAct=EBI-945833, EBI-10180762;
CC       V9HWJ5:HEL-S-90n; NbExp=3; IntAct=EBI-945833, EBI-10330335;
CC       A4FTV9:HIST1H2AK; NbExp=3; IntAct=EBI-945833, EBI-10173457;
CC       P49639:HOXA1; NbExp=5; IntAct=EBI-945833, EBI-740785;
CC       P37235:HPCAL1; NbExp=5; IntAct=EBI-945833, EBI-749311;
CC       O75506:HSBP1; NbExp=3; IntAct=EBI-945833, EBI-748664;
CC       Q9H2F3:HSD3B7; NbExp=3; IntAct=EBI-945833, EBI-3918847;
CC       Q96MM6:HSPA12B; NbExp=5; IntAct=EBI-945833, EBI-10291310;
CC       Q9NZL4:HSPBP1; NbExp=3; IntAct=EBI-945833, EBI-356763;
CC       P10809:HSPD1; NbExp=3; IntAct=EBI-945833, EBI-352528;
CC       Q14773-3:ICAM4; NbExp=5; IntAct=EBI-945833, EBI-10233928;
CC       P13284:IFI30; NbExp=3; IntAct=EBI-945833, EBI-2868897;
CC       P31785:IL2RG; NbExp=3; IntAct=EBI-945833, EBI-80475;
CC       Q92835:INPP5D; NbExp=3; IntAct=EBI-945833, EBI-1380477;
CC       P05107:ITGB2; NbExp=8; IntAct=EBI-945833, EBI-300173;
CC       L7RT22:ITGB5; NbExp=3; IntAct=EBI-945833, EBI-10178729;
CC       Q15040:JOSD1; NbExp=5; IntAct=EBI-945833, EBI-2510602;
CC       Q96SI1:KCTD15; NbExp=3; IntAct=EBI-945833, EBI-715783;
CC       Q2WGJ6:KLHL38; NbExp=5; IntAct=EBI-945833, EBI-6426443;
CC       O60259:KLK8; NbExp=5; IntAct=EBI-945833, EBI-3915857;
CC       P35900:KRT20; NbExp=3; IntAct=EBI-945833, EBI-742094;
CC       P78385:KRT83; NbExp=5; IntAct=EBI-945833, EBI-10221390;
CC       P60412:KRTAP10-11; NbExp=3; IntAct=EBI-945833, EBI-10217483;
CC       P60370:KRTAP10-5; NbExp=5; IntAct=EBI-945833, EBI-10172150;
CC       P60409:KRTAP10-7; NbExp=3; IntAct=EBI-945833, EBI-10172290;
CC       P60410:KRTAP10-8; NbExp=5; IntAct=EBI-945833, EBI-10171774;
CC       P60411:KRTAP10-9; NbExp=5; IntAct=EBI-945833, EBI-10172052;
CC       P59991:KRTAP12-2; NbExp=5; IntAct=EBI-945833, EBI-10176379;
CC       P60329:KRTAP12-4; NbExp=5; IntAct=EBI-945833, EBI-10176396;
CC       Q3SY46:KRTAP13-3; NbExp=5; IntAct=EBI-945833, EBI-10241252;
CC       Q6PEX3:KRTAP26-1; NbExp=5; IntAct=EBI-945833, EBI-3957672;
CC       Q9BYR8:KRTAP3-1; NbExp=3; IntAct=EBI-945833, EBI-9996449;
CC       Q9BYQ6:KRTAP4-11; NbExp=5; IntAct=EBI-945833, EBI-10302392;
CC       Q9BQ66:KRTAP4-12; NbExp=3; IntAct=EBI-945833, EBI-739863;
CC       Q9BYR5:KRTAP4-2; NbExp=5; IntAct=EBI-945833, EBI-10172511;
CC       Q9BYR0:KRTAP4-7; NbExp=3; IntAct=EBI-945833, EBI-10302547;
CC       Q6L8G9:KRTAP5-6; NbExp=5; IntAct=EBI-945833, EBI-10250562;
CC       P26371:KRTAP5-9; NbExp=5; IntAct=EBI-945833, EBI-3958099;
CC       Q9BYQ4:KRTAP9-2; NbExp=5; IntAct=EBI-945833, EBI-1044640;
CC       Q9BYQ2:KRTAP9-4; NbExp=3; IntAct=EBI-945833, EBI-10185730;
CC       Q5T7P3:LCE1B; NbExp=5; IntAct=EBI-945833, EBI-10245913;
CC       Q5TA82:LCE2D; NbExp=5; IntAct=EBI-945833, EBI-10246750;
CC       Q5T5A8:LCE3C; NbExp=5; IntAct=EBI-945833, EBI-10245291;
CC       Q5T5B0:LCE3E; NbExp=5; IntAct=EBI-945833, EBI-10245456;
CC       Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-945833, EBI-10257651;
CC       O14910:LIN7A; NbExp=3; IntAct=EBI-945833, EBI-2513988;
CC       Q96FQ7:LINC00526; NbExp=5; IntAct=EBI-945833, EBI-10286106;
CC       P25791:LMO2; NbExp=3; IntAct=EBI-945833, EBI-739696;
CC       Q8TBB1:LNX1; NbExp=5; IntAct=EBI-945833, EBI-739832;
CC       Q17RD9:LOC200261; NbExp=3; IntAct=EBI-945833, EBI-10239007;
CC       Q496Y0:LONRF3; NbExp=3; IntAct=EBI-945833, EBI-2690768;
CC       O75427:LRCH4; NbExp=3; IntAct=EBI-945833, EBI-718707;
CC       Q6PJG9:LRFN4; NbExp=5; IntAct=EBI-945833, EBI-7910762;
CC       O60336:MAPKBP1; NbExp=5; IntAct=EBI-945833, EBI-947402;
CC       Q6IPE9:MARK4; NbExp=3; IntAct=EBI-945833, EBI-10250211;
CC       O15232:MATN3; NbExp=3; IntAct=EBI-945833, EBI-6262458;
CC       P08582-2:MELTF; NbExp=5; IntAct=EBI-945833, EBI-10195914;
CC       Q4ZG74:MGC13033; NbExp=3; IntAct=EBI-945833, EBI-10241963;
CC       Q9NV56:MRGBP; NbExp=5; IntAct=EBI-945833, EBI-399076;
CC       Q9NQ50:MRPL40; NbExp=5; IntAct=EBI-945833, EBI-1053902;
CC       Q13330:MTA1; NbExp=5; IntAct=EBI-945833, EBI-714236;
CC       Q9BW11:MXD3; NbExp=5; IntAct=EBI-945833, EBI-741574;
CC       P50539-3:MXI1; NbExp=5; IntAct=EBI-945833, EBI-10211940;
CC       Q15742:NAB2; NbExp=3; IntAct=EBI-945833, EBI-8641936;
CC       Q8IW45:NAXD; NbExp=3; IntAct=EBI-945833, EBI-8650724;
CC       Q92692:NECTIN2; NbExp=3; IntAct=EBI-945833, EBI-718419;
CC       Q9NQS3:NECTIN3; NbExp=3; IntAct=EBI-945833, EBI-2826725;
CC       Q9Y3R4:NEU2; NbExp=6; IntAct=EBI-945833, EBI-10327976;
CC       P48645:NMU; NbExp=5; IntAct=EBI-945833, EBI-10210351;
CC       P48146:NPBWR2; NbExp=3; IntAct=EBI-945833, EBI-10210114;
CC       Q9NQX5:NPDC1; NbExp=5; IntAct=EBI-945833, EBI-748927;
CC       P16860:NPPB; NbExp=3; IntAct=EBI-945833, EBI-747044;
CC       Q6NSM0:NR1D2; NbExp=5; IntAct=EBI-945833, EBI-10250949;
CC       Q9Y5Y2:NUBP2; NbExp=3; IntAct=EBI-945833, EBI-1048886;
CC       Q99571:P2RX4; NbExp=5; IntAct=EBI-945833, EBI-2828248;
CC       Q9H1Q7:PCED1A; NbExp=3; IntAct=EBI-945833, EBI-748452;
CC       Q96HM7:PCED1B; NbExp=3; IntAct=EBI-945833, EBI-1222622;
CC       Q92824:PCSK5; NbExp=3; IntAct=EBI-945833, EBI-751290;
CC       O76083:PDE9A; NbExp=3; IntAct=EBI-945833, EBI-742764;
CC       Q7Z2X4:PID1; NbExp=3; IntAct=EBI-945833, EBI-10256685;
CC       Q96S52:PIGS; NbExp=5; IntAct=EBI-945833, EBI-2908273;
CC       O43688:PLPP2; NbExp=3; IntAct=EBI-945833, EBI-722017;
CC       Q9NRQ2:PLSCR4; NbExp=3; IntAct=EBI-945833, EBI-769257;
CC       Q8NAT1:POMGNT2; NbExp=3; IntAct=EBI-945833, EBI-10269044;
CC       P54646:PRKAA2; NbExp=3; IntAct=EBI-945833, EBI-1383852;
CC       Q8WWY3:PRPF31; NbExp=6; IntAct=EBI-945833, EBI-1567797;
CC       P11908:PRPS2; NbExp=3; IntAct=EBI-945833, EBI-4290895;
CC       P25786:PSMA1; NbExp=5; IntAct=EBI-945833, EBI-359352;
CC       Q969U7:PSMG2; NbExp=3; IntAct=EBI-945833, EBI-723276;
CC       P43115-12:PTGER3; NbExp=3; IntAct=EBI-945833, EBI-10234038;
CC       Q8WUK0:PTPMT1; NbExp=5; IntAct=EBI-945833, EBI-7199479;
CC       Q9H3S7:PTPN23; NbExp=3; IntAct=EBI-945833, EBI-724478;
CC       P15151:PVR; NbExp=5; IntAct=EBI-945833, EBI-3919694;
CC       Q9Y2K5-2:R3HDM2; NbExp=3; IntAct=EBI-945833, EBI-10326419;
CC       Q8TBN0:RAB3IL1; NbExp=5; IntAct=EBI-945833, EBI-743796;
CC       O60896:RAMP3; NbExp=5; IntAct=EBI-945833, EBI-720447;
CC       Q96PM5:RCHY1; NbExp=3; IntAct=EBI-945833, EBI-947779;
CC       Q6P9E2:RECK; NbExp=5; IntAct=EBI-945833, EBI-10253121;
CC       P07949:RET; NbExp=3; IntAct=EBI-945833, EBI-2480756;
CC       P07949-2:RET; NbExp=3; IntAct=EBI-945833, EBI-4423689;
CC       O15211:RGL2; NbExp=3; IntAct=EBI-945833, EBI-712355;
CC       P62857:RPS28; NbExp=3; IntAct=EBI-945833, EBI-353027;
CC       Q86UN2:RTN4RL1; NbExp=5; IntAct=EBI-945833, EBI-10258951;
CC       Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-945833, EBI-10313866;
CC       Q9BWG6:SCNM1; NbExp=5; IntAct=EBI-945833, EBI-748391;
CC       O00560:SDCBP; NbExp=3; IntAct=EBI-945833, EBI-727004;
CC       Q8WWX9:SELENOM; NbExp=3; IntAct=EBI-945833, EBI-10277687;
CC       Q9C0C4:SEMA4C; NbExp=5; IntAct=EBI-945833, EBI-10303490;
CC       A1A5C7:SLC22A23; NbExp=3; IntAct=EBI-945833, EBI-10171756;
CC       Q9UHI7:SLC23A1; NbExp=3; IntAct=EBI-945833, EBI-1759386;
CC       Q9UBX3:SLC25A10; NbExp=3; IntAct=EBI-945833, EBI-750394;
CC       P12236:SLC25A6; NbExp=3; IntAct=EBI-945833, EBI-356254;
CC       Q9NP91:SLC6A20; NbExp=5; IntAct=EBI-945833, EBI-10311198;
CC       Q969G3:SMARCE1; NbExp=3; IntAct=EBI-945833, EBI-455078;
CC       P49901:SMCP; NbExp=5; IntAct=EBI-945833, EBI-750494;
CC       Q9H4F8:SMOC1; NbExp=3; IntAct=EBI-945833, EBI-2801103;
CC       O95863:SNAI1; NbExp=3; IntAct=EBI-945833, EBI-1045459;
CC       Q6RVD6:SPATA8; NbExp=5; IntAct=EBI-945833, EBI-8635958;
CC       Q9UQ90:SPG7; NbExp=5; IntAct=EBI-945833, EBI-717201;
CC       P20155:SPINK2; NbExp=3; IntAct=EBI-945833, EBI-10200479;
CC       O43609:SPRY1; NbExp=5; IntAct=EBI-945833, EBI-3866665;
CC       O75716:STK16; NbExp=5; IntAct=EBI-945833, EBI-749295;
CC       Q8IV04:TBC1D10C; NbExp=3; IntAct=EBI-945833, EBI-10261452;
CC       Q7L2K0:TEDC2; NbExp=3; IntAct=EBI-945833, EBI-8465456;
CC       Q9BT49:THAP7; NbExp=5; IntAct=EBI-945833, EBI-741350;
CC       Q5TEJ8:THEMIS2; NbExp=3; IntAct=EBI-945833, EBI-2806032;
CC       Q9GZM7-3:TINAGL1; NbExp=3; IntAct=EBI-945833, EBI-10303636;
CC       Q86TG1:TMEM150A; NbExp=5; IntAct=EBI-945833, EBI-2799342;
CC       Q9H6L2:TMEM231; NbExp=3; IntAct=EBI-945833, EBI-10307654;
CC       Q96HV5:TMEM41A; NbExp=3; IntAct=EBI-945833, EBI-10288884;
CC       Q96KP6:TNIP3; NbExp=5; IntAct=EBI-945833, EBI-2509913;
CC       Q07912:TNK2; NbExp=3; IntAct=EBI-945833, EBI-603457;
CC       Q4VB56:TNP2; NbExp=3; IntAct=EBI-945833, EBI-10241829;
CC       P14373:TRIM27; NbExp=3; IntAct=EBI-945833, EBI-719493;
CC       Q8IWZ5:TRIM42; NbExp=8; IntAct=EBI-945833, EBI-5235829;
CC       O14817:TSPAN4; NbExp=5; IntAct=EBI-945833, EBI-8652667;
CC       Q86UY0:TXNDC5; NbExp=5; IntAct=EBI-945833, EBI-2825190;
CC       Q9BRU9:UTP23; NbExp=5; IntAct=EBI-945833, EBI-5457544;
CC       Q9UBK9:UXT; NbExp=5; IntAct=EBI-945833, EBI-357355;
CC       Q64LD2:WDR25; NbExp=3; IntAct=EBI-945833, EBI-744560;
CC       Q06250:WT1-AS; NbExp=5; IntAct=EBI-945833, EBI-10223946;
CC       Q9UBD3:XCL2; NbExp=3; IntAct=EBI-945833, EBI-10319095;
CC       Q9GZM5:YIPF3; NbExp=3; IntAct=EBI-945833, EBI-743787;
CC       Q9Y260:ZFAB; NbExp=3; IntAct=EBI-945833, EBI-750052;
CC       Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-945833, EBI-2849569;
CC       Q15973:ZNF124; NbExp=4; IntAct=EBI-945833, EBI-2555767;
CC       P17041:ZNF32; NbExp=3; IntAct=EBI-945833, EBI-1965483;
CC       Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-945833, EBI-740727;
CC       Q8NDP4:ZNF439; NbExp=3; IntAct=EBI-945833, EBI-747580;
CC       Q8IYI8:ZNF440; NbExp=5; IntAct=EBI-945833, EBI-726439;
CC       Q9NWS9-2:ZNF446; NbExp=5; IntAct=EBI-945833, EBI-740232;
CC       Q9P0T4:ZNF581; NbExp=5; IntAct=EBI-945833, EBI-745520;
CC       Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-945833, EBI-6427977;
CC       A0A0S2Z5X4:ZNF688; NbExp=3; IntAct=EBI-945833, EBI-16429014;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14673143,
CC       ECO:0000269|PubMed:29856954}. Cytoplasm
CC       {ECO:0000269|PubMed:14673143}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q7Z3S9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7Z3S9-2; Sequence=VSP_033896;
CC         Note=No experimental confirmation available.;
CC       Name=3;
CC         IsoId=Q7Z3S9-3; Sequence=VSP_033895;
CC   -!- TISSUE SPECIFICITY: Widely expressed with higher levels in
CC       leukocytes and lymph nodes (PubMed:14673143). Expressed in radial
CC       glia neural stem cells during cortical development
CC       (PubMed:29856954). {ECO:0000269|PubMed:14673143,
CC       ECO:0000269|PubMed:29856954}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at low levels at 7-9 gestational
CC       weeks and then increases at later stages, including in the non-
CC       cortical plate region at gestational week 21, containing the
CC       outer-subventricular zone (PubMed:29856955). Expressed at lower
CC       level than NOTCH2NLB (PubMed:29856955).
CC       {ECO:0000269|PubMed:29856955}.
CC   -!- PTM: Cleaved by ELANE. {ECO:0000269|PubMed:14673143}.
CC   -!- DISEASE: Note=Defects in NOTCH2NLA may be a cause of chromosome
CC       1q21.1 deletion/duplication syndrome (PubMed:29856954). Deletions
CC       of NOTCH2NL (NOTCH2NLA, NOTCH2NLB and/or NOTCH2NLC) are present in
CC       patients affected by microcephaly, whereas macrocephaly is
CC       observed in patients with NOTCH2NL duplications (PubMed:29856954).
CC       {ECO:0000269|PubMed:29856954}.
CC   -!- SIMILARITY: Belongs to the NOTCH family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH84572.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC11381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AK075065; BAC11381.1; ALT_INIT; mRNA.
DR   EMBL; BX537434; CAD97676.1; -; mRNA.
DR   EMBL; AL592307; CAH73993.1; -; Genomic_DNA.
DR   EMBL; AL592307; CAH73994.1; -; Genomic_DNA.
DR   EMBL; BC010154; AAH10154.3; -; mRNA.
DR   EMBL; BC019835; AAH19835.1; -; mRNA.
DR   EMBL; BC065219; AAH65219.2; -; mRNA.
DR   EMBL; BC084572; AAH84572.1; ALT_INIT; mRNA.
DR   EMBL; BC090943; AAH90943.1; -; mRNA.
DR   CCDS; CCDS72880.1; -. [Q7Z3S9-1]
DR   RefSeq; NP_982283.2; NM_203458.4. [Q7Z3S9-1]
DR   RefSeq; XP_006711766.1; XM_006711703.3.
DR   RefSeq; XP_006726418.1; XM_006726355.3.
DR   RefSeq; XP_016855384.1; XM_016999895.1.
DR   RefSeq; XP_016855385.1; XM_016999896.1.
DR   RefSeq; XP_016855386.1; XM_016999897.1.
DR   RefSeq; XP_016855387.1; XM_016999898.1.
DR   RefSeq; XP_016858537.1; XM_017003048.1. [Q7Z3S9-1]
DR   RefSeq; XP_016858538.1; XM_017003049.1. [Q7Z3S9-1]
DR   RefSeq; XP_016858539.1; XM_017003050.1. [Q7Z3S9-1]
DR   RefSeq; XP_016858540.1; XM_017003051.1.
DR   UniGene; Hs.655156; -.
DR   UniGene; Hs.683989; -.
DR   UniGene; Hs.728902; -.
DR   ProteinModelPortal; Q7Z3S9; -.
DR   SMR; Q7Z3S9; -.
DR   BioGrid; 132802; 247.
DR   DIP; DIP-47315N; -.
DR   IntAct; Q7Z3S9; 352.
DR   STRING; 9606.ENSP00000464060; -.
DR   BioMuta; NOTCH2NL; -.
DR   DMDM; 74750065; -.
DR   EPD; Q7Z3S9; -.
DR   jPOST; Q7Z3S9; -.
DR   MaxQB; Q7Z3S9; -.
DR   PaxDb; Q7Z3S9; -.
DR   PeptideAtlas; Q7Z3S9; -.
DR   PRIDE; Q7Z3S9; -.
DR   ProteomicsDB; 69079; -.
DR   ProteomicsDB; 69080; -. [Q7Z3S9-2]
DR   ProteomicsDB; 69081; -. [Q7Z3S9-3]
DR   TopDownProteomics; Q7Z3S9-3; -. [Q7Z3S9-3]
DR   DNASU; 388677; -.
DR   Ensembl; ENST00000362074; ENSP00000354929; ENSG00000264343. [Q7Z3S9-1]
DR   Ensembl; ENST00000578207; ENSP00000464060; ENSG00000264343. [Q7Z3S9-1]
DR   Ensembl; ENST00000579793; ENSP00000476330; ENSG00000264343. [Q7Z3S9-2]
DR   GeneID; 100996717; -.
DR   GeneID; 100996763; -.
DR   GeneID; 388677; -.
DR   KEGG; hsa:388677; -.
DR   UCSC; uc031utx.2; human. [Q7Z3S9-1]
DR   CTD; 100996717; -.
DR   CTD; 100996763; -.
DR   CTD; 388677; -.
DR   DisGeNET; 100996717; -.
DR   DisGeNET; 100996763; -.
DR   DisGeNET; 388677; -.
DR   EuPathDB; HostDB:ENSG00000264343.5; -.
DR   GeneCards; NOTCH2NL; -.
DR   HGNC; HGNC:31862; NOTCH2NLA.
DR   HPA; CAB004669; -.
DR   MIM; 618023; gene.
DR   neXtProt; NX_Q7Z3S9; -.
DR   OpenTargets; ENSG00000264343; -.
DR   OpenTargets; ENSG00000271383; -.
DR   PharmGKB; PA134983899; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410XP6K; LUCA.
DR   GeneTree; ENSGT00420000029746; -.
DR   GeneTree; ENSGT00940000167308; -.
DR   HOVERGEN; HBG104750; -.
DR   InParanoid; Q7Z3S9; -.
DR   OMA; GINAYYC; -.
DR   OrthoDB; 1033311at2759; -.
DR   PhylomeDB; Q7Z3S9; -.
DR   ChiTaRS; NOTCH2NL; human.
DR   PMAP-CutDB; Q7Z3S9; -.
DR   PRO; PR:Q7Z3S9; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000264343; Expressed in 91 organ(s), highest expression level in testis.
DR   Genevisible; Q7Z3S9; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005112; F:Notch binding; IPI:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0021987; P:cerebral cortex development; IDA:UniProtKB.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IDA:UniProtKB.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   Pfam; PF00008; EGF; 3.
DR   Pfam; PF07645; EGF_CA; 1.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00179; EGF_CA; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 5.
DR   PROSITE; PS50026; EGF_3; 6.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Calcium; Complete proteome; Cytoplasm;
KW   Developmental protein; Differentiation; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Notch signaling pathway; Polymorphism;
KW   Reference proteome; Repeat; Secreted.
FT   CHAIN         1    236       Notch homolog 2 N-terminal-like protein
FT                                A.
FT                                /FTId=PRO_0000337103.
FT   DOMAIN        1     24       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN       25     63       EGF-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN       66    104       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      105    141       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      143    180       EGF-like 5; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      182    219       EGF-like 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   CARBOHYD      7      7       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     14     23       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     29     40       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     34     51       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     53     62       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     70     82       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     76     92       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     94    103       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    109    120       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    114    129       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    131    140       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    147    159       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    153    168       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    170    179       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    186    197       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    191    207       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   VAR_SEQ       1      1       M -> MCRDGYEPCVNEGM (in isoform 3).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_033895.
FT   VAR_SEQ     212    236       ETVRRGTELWERDREVWNGKEHDEN -> ATWPIFPKLLSL
FT                                QEKESYC (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_033896.
FT   VARIANT      67     67       S -> P (in dbSNP:rs10910779).
FT                                /FTId=VAR_043601.
FT   VARIANT     158    158       T -> I (in dbSNP:rs8002).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_043602.
FT   VARIANT     196    196       T -> S (in dbSNP:rs4649852).
FT                                /FTId=VAR_043603.
FT   VARIANT     226    226       E -> Q (in dbSNP:rs1053710).
FT                                /FTId=VAR_043604.
FT   CONFLICT     19     19       L -> S (in Ref. 1; BAC11381).
FT                                {ECO:0000305}.
SQ   SEQUENCE   236 AA;  25835 MW;  2DF01880A22814C9 CRC64;
     MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE
     DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC
     TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD
     SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN
//
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