GenomeNet

Database: UniProt
Entry: Q7Z5P9
LinkDB: Q7Z5P9
Original site: Q7Z5P9 
ID   MUC19_HUMAN             Reviewed;        8384 AA.
AC   Q7Z5P9; G3CIG0; Q8NA85;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-JUN-2016, sequence version 3.
DT   08-MAY-2019, entry version 99.
DE   RecName: Full=Mucin-19;
DE            Short=MUC-19;
DE   Flags: Precursor;
GN   Name=MUC19;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Salivary gland;
RX   PubMed=21075863; DOI=10.1165/rcmb.2010-0312OC;
RA   Zhu L., Lee P., Yu D., Tao S., Chen Y.;
RT   "Cloning and Characterization of Human MUC19 Gene.";
RL   Am. J. Respir. Cell Mol. Biol. 45:348-358(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7684-8384 (ISOFORM 1), AND TISSUE
RP   SPECIFICITY.
RX   PubMed=12882755; DOI=10.1165/rcmb.2003-0103OC;
RA   Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D.,
RA   Ann D.K., Wu R.;
RT   "Genome-wide search and identification of a novel gel-forming mucin
RT   MUC19/Muc19 in glandular tissues.";
RL   Am. J. Respir. Cell Mol. Biol. 30:155-165(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7684-8384 (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=17667140; DOI=10.1097/MLG.0b013e31806db531;
RA   Kerschner J.E.;
RT   "Mucin gene expression in human middle ear epithelium.";
RL   Laryngoscope 117:1666-1676(2007).
RN   [6]
RP   FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=18184611; DOI=10.1016/j.exer.2007.11.013;
RA   Yu D.F., Chen Y., Han J.M., Zhang H., Chen X.P., Zou W.J., Liang L.Y.,
RA   Xu C.C., Liu Z.G.;
RT   "MUC19 expression in human ocular surface and lacrimal gland and its
RT   alteration in Sjogren syndrome patients.";
RL   Exp. Eye Res. 86:403-411(2008).
CC   -!- FUNCTION: May function in ocular mucus homeostasis.
CC       {ECO:0000269|PubMed:18184611}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7Z5P9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7Z5P9-2; Sequence=VSP_034521, VSP_034522;
CC         Note=No experimental confirmation available.;
CC   -!- TISSUE SPECIFICITY: Expressed corneal epithelial cells,
CC       conjunctival goblet and epithelial cells and lacrimal gland cells
CC       (at protein level). Expressed by mucous cells of the submandibular
CC       gland and submucosal gland of the trachea. Expressed by middle ear
CC       epithelial cells. {ECO:0000269|PubMed:12882755,
CC       ECO:0000269|PubMed:17667140, ECO:0000269|PubMed:18184611}.
CC   -!- INDUCTION: Down-regulated in Sjoegren syndrome patients (at
CC       protein level). {ECO:0000269|PubMed:18184611}.
CC   -!- CAUTION: According to the Genome Reference Consortium, the
CC       reference genome GRCh38/hg38 is in conflict with the sequence
CC       shown here. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Mucin database;
CC       URL="http://www.medkem.gu.se/mucinbiology/databases/";
DR   EMBL; HM801842; AEM63682.1; -; mRNA.
DR   EMBL; AC024935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC074030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY236870; AAP41817.1; -; mRNA.
DR   EMBL; AK093065; BAC04041.1; ALT_INIT; mRNA.
DR   RefSeq; NP_775871.2; NM_173600.2. [Q7Z5P9-1]
DR   SMR; Q7Z5P9; -.
DR   iPTMnet; Q7Z5P9; -.
DR   PhosphoSitePlus; Q7Z5P9; -.
DR   BioMuta; HGNC:14362; -.
DR   EPD; Q7Z5P9; -.
DR   jPOST; Q7Z5P9; -.
DR   PaxDb; Q7Z5P9; -.
DR   PeptideAtlas; Q7Z5P9; -.
DR   PRIDE; Q7Z5P9; -.
DR   ProteomicsDB; 69340; -.
DR   ProteomicsDB; 69341; -. [Q7Z5P9-2]
DR   GeneID; 283463; -.
DR   KEGG; hsa:283463; -.
DR   CTD; 283463; -.
DR   DisGeNET; 283463; -.
DR   GeneCards; MUC19; -.
DR   H-InvDB; HIX0210549; -.
DR   HGNC; HGNC:14362; MUC19.
DR   MIM; 612170; gene.
DR   neXtProt; NX_Q7Z5P9; -.
DR   eggNOG; ENOG410IR85; Eukaryota.
DR   eggNOG; ENOG410ZXRK; LUCA.
DR   InParanoid; Q7Z5P9; -.
DR   KO; K22020; -.
DR   OrthoDB; 12226at2759; -.
DR   Reactome; R-HSA-5083625; Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
DR   Reactome; R-HSA-5083632; Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
DR   Reactome; R-HSA-5083636; Defective GALNT12 causes colorectal cancer 1 (CRCS1).
DR   Reactome; R-HSA-5621480; Dectin-2 family.
DR   Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR   Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR   ChiTaRS; MUC19; human.
DR   GenomeRNAi; 283463; -.
DR   PRO; PR:Q7Z5P9; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0016266; P:O-glycan processing; TAS:Reactome.
DR   GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   Pfam; PF08742; C8; 2.
DR   Pfam; PF01826; TIL; 1.
DR   Pfam; PF00094; VWD; 3.
DR   SMART; SM00832; C8; 2.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00214; VWC; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 3.
DR   SUPFAM; SSF57567; SSF57567; 3.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS50184; VWFC_2; 1.
DR   PROSITE; PS51233; VWFD; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Disulfide bond; Polymorphism;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22   8384       Mucin-19.
FT                                /FTId=PRO_0000342664.
FT   DOMAIN      479    681       VWFD 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      815   1023       VWFD 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN     1275   1484       VWFD 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN     8159   8225       VWFC. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     8288   8376       CTCK. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00039}.
FT   REGION     2238   6086       Approximate repeats of G-V-T-G-T-T-G-P-S-
FT                                A. {ECO:0000305}.
FT   COMPBIAS    195    441       Gly-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00008}.
FT   COMPBIAS    273    451       Ser-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00016}.
FT   COMPBIAS   1638   8149       Thr-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00017}.
FT   DISULFID    502    510       {ECO:0000255|PROSITE-ProRule:PRU00580}.
FT   DISULFID   8288   8339       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   8306   8353       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   8315   8369       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   8319   8371       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   VAR_SEQ    8049   8066       GNTPGSTGVTSSQEGTTV -> DSPSFPLFLICSYRGHNF
FT                                (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_034521.
FT   VAR_SEQ    8067   8384       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_034522.
FT   VARIANT     717    717       G -> E (in dbSNP:rs7955308).
FT                                /FTId=VAR_056617.
FT   VARIANT     783    783       T -> K (in dbSNP:rs11564170).
FT                                /FTId=VAR_056618.
FT   VARIANT     790    790       V -> I (in dbSNP:rs7958987).
FT                                /FTId=VAR_056619.
FT   VARIANT     791    791       R -> L (in dbSNP:rs17467284).
FT                                /FTId=VAR_056620.
FT   VARIANT     803    803       D -> H (in dbSNP:rs11564245).
FT                                /FTId=VAR_056621.
FT   VARIANT     843    843       V -> I (in dbSNP:rs10506156).
FT                                /FTId=VAR_056622.
FT   VARIANT     869    869       V -> I (in dbSNP:rs28365246).
FT                                /FTId=VAR_056623.
FT   VARIANT     883    883       V -> I (in dbSNP:rs11564125).
FT                                /FTId=VAR_056624.
FT   VARIANT    1010   1010       L -> F (in dbSNP:rs12317988).
FT                                /FTId=VAR_056625.
FT   VARIANT    1151   1151       I -> T (in dbSNP:rs11176635).
FT                                /FTId=VAR_056626.
FT   VARIANT    1226   1226       S -> F (in dbSNP:rs4768261).
FT                                /FTId=VAR_056627.
FT   VARIANT    1278   1278       I -> M (in dbSNP:rs7966110).
FT                                /FTId=VAR_056628.
FT   VARIANT    1296   1296       G -> S (in dbSNP:rs4768264).
FT                                /FTId=VAR_056629.
FT   VARIANT    1315   1315       R -> H (in dbSNP:rs7312154).
FT                                /FTId=VAR_056630.
FT   VARIANT    1327   1327       G -> W (in dbSNP:rs12369002).
FT                                /FTId=VAR_056631.
FT   VARIANT    1367   1367       A -> T (in dbSNP:rs11564141).
FT                                /FTId=VAR_056632.
FT   VARIANT    1411   1411       C -> Y (in dbSNP:rs11564109).
FT                                /FTId=VAR_056633.
FT   VARIANT    1451   1451       A -> T (in dbSNP:rs11176666).
FT                                /FTId=VAR_056634.
FT   VARIANT    1493   1493       A -> V (in dbSNP:rs10784621).
FT                                /FTId=VAR_056635.
FT   VARIANT    1621   1621       N -> S (in dbSNP:rs17128169).
FT                                /FTId=VAR_056636.
FT   VARIANT    1688   1688       T -> A (in dbSNP:rs17128233).
FT                                /FTId=VAR_056637.
FT   VARIANT    1762   1762       E -> A (in dbSNP:rs2933353).
FT                                /FTId=VAR_056638.
FT   VARIANT    1770   1770       S -> R (in dbSNP:rs7956459).
FT                                /FTId=VAR_056639.
FT   VARIANT    2029   2029       A -> S (in dbSNP:rs1492333).
FT                                /FTId=VAR_056640.
FT   CONFLICT   8091   8091       T -> S (in Ref. 3; AAP41817).
FT                                {ECO:0000305}.
FT   CONFLICT   8327   8327       Y -> H (in Ref. 3; AAP41817).
FT                                {ECO:0000305}.
SQ   SEQUENCE   8384 AA;  805253 MW;  D4FFE16047237C93 CRC64;
     MKLILWYLVV ALWCFFKDVE ALLYRQKSDG KIAASRSGGF SYGSSSSGDL DRKKPLFSLE
     FGSPGETEDK SRQRQDAGSP KSEDTPAGGF FNSSSSSGDS DRTKPFFSLG LGAPGKAEDK
     SGDSQDAGGS KSEDTPPGGF FYGSSSSGDS DKKKPLFSFE FGATGEDEDK SRERWDAGNS
     RSEDSPADST NTRYGAGFSS SGASLDVGFG WGISDEKGLE VSKADGRETR GSGSAGGETI
     VFGPDAGSSV GTGSSGLKLG AGKGDAAFGF EVSDSNSFGD TGISSKTVEG NQTSSSGGSV
     SIDLGDTSFR SENQFVGGGS LNSISNLWDS GQEGFGINEI GGNGMSGSVS AEAGFKGFGS
     DSSSSGDSSA RNGFENSSGI SEDSGVILGS SDQHEVELSR TGGNRKRSSD PDEAGNLSPG
     SDVSDSGGNT WSSDSGSGGG GVTSSSEYST SGPLNTPEKG SHIPEATPKY SETNAIIGEI
     STWSKGAYKS FNGRIFFFES SCPYTFCRHC IESGGDFNIE IKRNNDSEIE KITVLIDNND
     VSIFGDTILV NGESVQIPYN NKLIHIKKYG EHNVLNSRRG ILTLMWDKNN KLSLTLHKQY
     PTCGLCGNFN STPGQDINEH IANSKIPGDC PNAVGKSYEV CEDGIQHCNK IIGTYFEKCG
     KVAALSNDYK MICIDEYCQT RDKTSTCDTY SELSRLCASD GPGTFESWRS DSDVVCGTQR
     CPEQHIYKEC GPSNPATCSN VAPFQDSECV SGCTCPEGYL LDDIGEKGKC VLKAECPCES
     SGTVYQPGEV REGPCGSQCT CQDAKWSCTE ALCPGRCKVE GSSLTTFDGV KYNFPGNCHF
     LAVHNEDWSI SVELRPCPSG QTGTCLNSVT LLLNSSVPVD KYVFNSDGTV TNDKIRNQGY
     YYSDKIQIFN ASSSYLQVET YFHVKLQIQI VPVMQLYVSM PPNQFTDTVG LCGSYNNKAE
     DDFMSSQNIL EKTSQAFANS WEMMSCPKGN PSSCISIEKE KFAERHCGIL LDSSGPLASC
     HPIVNPKPYH EECKKYTCTC ENSQDCLCTI LGNYVKACAE KETYIVGWRT GLCEHSCPSG
     LVFKYNVKAC NSSCRSLSER DRSCDVEDVP VDGCTCPDAM YQNNEGNCVL KSQCDCYIND
     EVMQPGKLIH IDDNKCVCRD GILLCQIPID LTLQNCSGGA EYVDCSDPKA QRRTNRTCST
     RNIPVFDENL PCKRGCFCPE GMVRNSKGIC VFPNDCPCSF GGREYDEGSV TSVGCNECTC
     IKGSWSCTQN ECQTICHIYG EGHVRTFDGK SYSFDGLCQY SFLEDYCGHE NGTFRILTES
     VPCCEDGLTC SRKIIVAFQD QNIVLQDGKV TAVKSTESKK CELNANAYSI HTVGLYLILK
     FQNGIIVIWD KNTRLSVILD PNWNGKVCGL CGNNNGDLKD DFTTRYSSVA SGALEFGNSW
     KTSQECSDTV AQTFPCDSNP YCKAWAVRKC EILRDSTFRD CHNKVDPSAY HDACIEEACA
     CDMEGKYLGF CTAVAMYAEA CSAVGVCVSW RKPNLCPVYC DYYNAPGECR WHYEPCGTVT
     AKTCKDQLVG QKFSSLLEGC YAKCPDSAPY LDENTMKCVS LSECSCFYND VIPAGGVIED
     NCGRTCYCIA GQLECSETAP TNSTFAVSTT TATTILSTGA AITLVTGGPS TAASIPAITT
     SSSETTGTTL GPLTEPFTTG ITETSVPIIS TSGNAGMTGV VSPTVTGASG MAGTTGGVDA
     ATTGAASENT SERAGTPRVS GETPAVGGGS TPGEAGPGAT VSGSTGVSAG SITASPGASA
     TSSESSKSGT TGPSVGGKTG ATSSEATSSE GMSGVTGQSL GSTAGSDSEI TAKTSFTGSS
     PPGKLTRPSP GSPGHFSGGT TEWGNVATTG AAGENTSGAL GSTEGSVEAT TSAGSGNTAG
     TSGTGDTGPG NTAVSGTPVV SPGATPGAPG SSTPGEADIG NTSFGKSGTP TVSAASTTSS
     PVSKHTDAAS ATAVTISGSK PGTPGTPGGA TSGGKITSGW SSSGTSTGAS NTPGATGSST
     GQTDTSGPSA KVTGNYGQSS EIPGTIKSSS DVSGTMGQSD TTSGPSVAVT RTSEQSSGVT
     VASEPSVGVS GTTGPLAEIS GTTRPLVSGL RTTGSSAEGS GTTGPSSRES VTTRPLAEGS
     GTSGQSVTGS RATGLSATEL GTTVSFTGGL GTSRSSARET RTTGPSADGS GTTGPSVVRS
     GTTRLSVGVT RATESSPGVT GTTTPSAEES RTTGPSVLVT GTTGQSGQGS GTTGKSFIES
     GPSVVGSGTT GPTSAGLGTT APSTRRSSTT KPSVGRTGTT GQSGAESGTT EPSARVAGVT
     GTSAEVSGRI EPSATESSTS RPLGETTGTT IPSMEGSEAT GPSVIGSETT RLSVIGSGTT
     GTSSGGSGAT RSSGGGMGTT GQSTARSETT GPLFGLTGTF GQSATVTGTS SNSAGVTTPE
     KSPGVAMTTG LLVEGSATTQ PRILESETTE SSAGVIVTSG QSARVTGATG PSAGETGTTE
     PSTEGSVAAV LFVIGSETTR PLDIGSGTTG TLSGGSSTTR SSDGTTGTTR KSTARSETTG
     LSGLTGTSGQ LAGVTGTSSK SAGVTVTSEK SAGVAVITGS FVERPVTTGP PLLESETTRP
     SGGVTVTSGQ SARVTETVGA SAGVTGTTGP STEGSGATGP SVVGSGTTRP LAGESGTTES
     SAGVTGTRPS SSRESATTGP SDEGSGTTGL SAGVTVTSGQ SVRKTGTTGA PAGVTETTRP
     SVVKSGTTGP SVIGTRTTGT SSGGSGATRS SGGETETTGQ SAVKSGTTES FTRLTRTSGQ
     SAGMTGTSAQ SAGVALTSPF VEGLVTTGSS TVGLETTRPS AVGSGKTGPP VVKAQTTGPS
     AGVTVTSGQS ARMTGASGPS VGVTGTTGPA SKGLGTIRPS VVGLETTELS AEGSGTTGPP
     IVGETTVPSA GVTVTSGYSD RVTGATEPLA GVTGTIKPSV AGSVTTGPSV TGVETTAKTT
     SGGLSTTISS VGGTGTTGQS PERSGTTGPF TGLTGTSAQS AGVTMTSIQS AGVLVTTGLN
     VDGLGTTGKA LIGSGTTGLS AEATGTIGPS TEGLEKTGPS ITGSGTTRPL VTESWTAGTS
     SGGHSTTSPS VRGTETTGQS AAESVTTGPV TGYTETSGPS AGVTVTPRQS PTVTQTTGSS
     AAVSGTTVQS LTVSGTTRPS SGQTEITGSS VKESGTTESS AVRSGTTGPT AGVTGTNGPS
     SAGVTGITGS SPGVTGTTGS SPGVTGTTGS SARSGTSIPS VGKTGTTRTS VEESRTTRPS
     AGITGTNGLS AEVTGTTGPL AGVTGTTGPS AGVTRTTGLS AGETGTTGLS PGVTRTTRSS
     AGLTGKTGLS AGVTGKTGLS AEVTGTTRLS AGVTGTTGPS PGVTGTTGTP AGVTGTTELS
     AGVTGKTGLS SEVTETTGLS YGVKRTIGLS AGSTGTSGQS AGVAGTTTLS AEVTGTTRPS
     AGVTGTTGLS AEVTEITGIS AVVTGTTGPS AGVTETTGSS AGVAGTTRLS AGVTGITGLS
     AGVTGTTGLS TEVTGTTGPS AGATGTTGLS VGVTGITGLS DVVTETTGSS ARSGTGIPSV
     GETRTTSTSV EESRTTRPSA GIMGTNGLPA EVTGTTEPLA GGTGTTGILA GVTGTTGLSA
     GETGKIGSSA GVTGKTGSSA RVTGKTGPSA EVTGKTGLSA GVTGTTGLSP GVTGTSGLSA
     EVTGTTGPSA EATGLPGVSA GVTGTTGSLA GGTGTIGLSA GVTGTTGSSA GVTGTTGLSA
     GVTGIAGLSA GVTGITGPSA GVTGTTTVSA GVTGTTGLSA EATEITGLSA GVTGTTGLSA
     GVTETIRLSA GVTGTIRSSA GVTGITGLSA GVTGTTGPSA GVTGSTGLLA GVTETTGQSA
     KVTGTTGQSV GVTGTTRSSG GVTGITGLSA GVTGTNGLSA VTGMTGLSAE VTGTTGLSVG
     VTGIAGLSAG VTGITGPSAG ITGTTTISAG VTGTSGLSAE ATGITGLSAG VTGKTGLSAG
     VTETIGLSAE ATGTIGSSPG VTGTTGSSTG VTGITGLSAG VTGTTGLSTE VTGTTGPSAG
     VTRTTGLSAG VTGITGLSAI VTETTGSSAR SGTSIPSVGE TGTTRTSVEE SRTTRPSAGI
     TGTNGLSAEV TGTIGPLAGG TGTTGLSAGV TGTVGSSAVV TGTTGLSAGV TGTTGPSAEE
     TGATGPSAEV TETTGPSAGV TGTGRLSAEV TGTTGPSAEV TGLPGESAEV TGTIGSPAGV
     TGTTQLSAVV TGITGLSAEV TGTTGLSAGV TGITGLSAEV TRTTGLSAGV TGTIGLSAGV
     TGTTRPSAGV TGTTGQSAEV TGTTEPSAGL TETTGSSTGV TGATGPLAGV TGTTGISTEV
     TGTTGPSARV TGTTVLSAGV TGITGLSAIV TETTGSSARS GTSTPSVGET GTTRTSVEES
     RATRPSAGIT GTNGQSAEVT WITGPLAGVT GTTGISAGVT GTTGLSAGVT GTIGSSAVVT
     GINGLSAGVT GTTGPSAEET GATGPSAEVT GTTGPSAEET GATGPSAEVT GTTGPSGGVT
     GTNGLSAEVT GTTGPSAEVT GLPGVSAGVT GTIGSPAAVT GTIRPSAVVT GITGLSAEVT
     GTTGLSAWVT GIAGLSAGVT ETIGSSAGVT GTNGLSAEAT GTTGPSAGVT GTTGLSAGVT
     GTAGLSARVT ESTGLSAGVT GTTGLSAGVT GTTGPSAGIT GTNGLSAEVT GTTGPLAGVT
     GTIGLSAGVT GIAGLSAGVT ESTGLSAGVT GTIRSSAVVT GINGLSAGVT GTTGPSAEET
     GATGPSAEVT GTTGPSGGVT GTSGISAEVT GTTGPSAEVT GLPGVSAGVT GTIGSPAAVT
     GTTRPSAVVT GISGLSAEVT GTTGLSAGVT ETIGSSAGVT GTNGLSAEAT ETTGPSAGVT
     GTTGLSAGVT GTTGPSAGIA GTNGLSAGVT GTTGLSARVT ESTGLSAGVT GTIGSSAVVT
     ETTRLSSGVT GTIGPSAEET GATGLSAEVT GTTGSLAEVT GTTGLSAGVT GTIGSSAVVT
     GTTGLSAGIT GTNGLSAEVT GTAGPLAGVT GTTGLSAGVT GTTGLSAGVT ETTGQSAGVT
     ESTGLSPGVT GTIGSSAVVT GIKGLSAGVT GTTGPSAEET GATGPSAEVT GTTGPSGGVT
     GTSVLSVEVT GTTGPSAEVT GLPGVSAGLT GTIGSPAAVR GTTWPSAVVT GISGLSGEVT
     GTTGLSAGVT GIGGLSAGVT GTIGSSAGVT GTNALSAEAT GTTGPSAGVT GTTGLSAGVT
     GTTGLSAGVT GTIRSSAVVT ETTGLSAGVT GTTGPSAGIA GTNGLSAEVT GTTGLSAGMT
     GTTGLSARVT ESTGLSAGVT GTIGSSAVVT ETTRLSAGVT GTIGPSAEET GATGLSAEVT
     RTTGSLAGVT GTTGPSAVVT GKTELSAEVT GTTELSAEVT EKTGPSAEVT GKTGLSAGVM
     ETTGPSAEVT GTTGSSAGVT GTTGPSAGVT GTTGPSAEAT GLPGVSAGVT GTIGSPAGVT
     GTARLSAVVT GISGLSAEVT GTTGLSTGVT GIAGHSAAVT GITRPSAGVT GTTTVSAGVT
     GTIGLSAEAT GITLPSAGVT ETTGLSAGVT ETIGLSAGVT GTIGSSAGVT EITGLSAGVT
     GTTGPSAGVT GSTVLSAGVT ATTGQSVGVT GTTGPSAGVT GTTGLSAGVT GIAGLSAGVT
     GITGPSAGVT GTTTVSAGVT GTTGLSAEAT EITGLSAGVT GTTGLSAGVT GIAGLSAGVT
     ETIGSSAGVT GTNGLSAEAT GKTGPSAGVT GTTGLSAGVT GTTGLSAGVT ETIGLSAGVT
     GTIGSSAGVK GTTGQSAEVT GATGQSVGVT GTTRSSGGVT GITGLSAGLR GTTVSSAKAG
     TSIPLTGKTG TTRTSVEEST TTGPSAGITG TNGLSAEMTG TNELSAGVTG TIGSSAGVTG
     TTGLSVEATV TTGLSAGVTG TTVPLAGVTW TPGPSAGVTG IAALSAGVTG KSGLSAGVTG
     KTGLSAGVTG TTGPSAEATG KTGLSAGVTG ITGPFAEVTG TTGLSAGVIG TTGSSAEVTG
     ITGLSAGVTG KTRSSAGVTG TTGLSAKSGT SIPSAGKTGT TKTSVEESRT TRPSAGITAT
     TGVPAATSPG AEGESIASTS VATGAIPRST IAPGSTTTGT TGVTTGTTLA PRSFNIGTSG
     GISGKTLKPG SYVSEATTAT GTPGAGPSGG TTISSPEVST ISEVSNTGIT GVGSETSIET
     GISNTATTGV APGTTLAPGS SSTEATTSIG GSASTRGGIA TEATGSTRGV RTTGSEAPEG
     TSGEFSGTTI SSGGFHTEAT TLTGGRGSIG TESRAESTTS LPQSAKTRGG ILTEATSSTG
     RIRATGSEAP GGTSRKFSGT TISSGGSHTE ATTLAGGRDS TESEFRTATI GVVPATTVAP
     GSSKTEATTF LGVSGTTSVG RATGATTSIA GSDTSQAEHP GGTSGEFPGT TITSGDSHTE
     ATALTGSRGS IGTESTVETT TYIGESGTTR GGLATATTGA FSGKTLEPGN DNTEATGSTG
     GIRATRTEAP GGTSGEFPGT TFTSGGSHTE ATTFTGGKGS TGTESRAATT RAAPGTTLVP
     GSSNTGATAS PGGSATTRGR ITTATTGAFS GKTLESENDN TEATSSTRGV RTTRSEAPGG
     TSGEFPGTRI TSGGSYTATT RAAPGTTLAP GSSNTGATAS LGGSAMTRGR ITTATTGAFS
     GKTLEPGNNN TEATSSTRGV RTTRSEAPGE ATTLTGDRSS TGSESRTATT GVAPGTTVAP
     GSSKTEATTF LGVSGTTNIG RATGATTSIV GSDTSQAERP GGTTVVSPGA SSTSQSSRPG
     TSVTPDSSAS ESETVTTKEF SGTTAISRTS HTGTPAASGG QATGSLTATT GVAPGTTVAP
     GSSNTEATTS VGERETTKAE IITGDTGELS GTTIISENST TAGITAATGK QAGTSEVAPS
     TTVAPGSFST AATTSPGASG TTGVTTTTKT TTSLGGSGTT GAEIKSATTG APGSRTGTAG
     VPSATTVSPG SSNSEATTSV GESGKTGAET ITEATTSTEG TGTSGTGFKT GTSEVAPATT
     VAPGSFSTAA TTSPGASGMT GVTTTTKTTT SLGGSGTTGA KIKLVGTTTT APESRTAGVP
     SGTRVTPGSS NSEATTSVEE SRITRAEVIT EATTFSGGSG ATRAGLPRGT TGEFSGTNFI
     SGSSNTEATT STEGTGTSGT GFKIAGITSA PGKQAGTSGV SLATTVAPGS FSTATTSSGA
     SGITRAGPTS ETTTSLGGSG TTGAEIKSAA VPSGTTVAPG SSNSEATTSV GENGKTRGEI
     ITDTTEGTSG KVLEPGSAHT EATTFPGGSG TTRAGPPGGT TGELSRMTII PGSSNTEATT
     STKGTGTSGT GFKTGTSWVA PGTTVSPGSF STATISPGAS RTTGAAPAAE TTTSLEGGGT
     TGAEIKSGAT SGVPGSKTGT AGVPSATTIA PGSSNSEATT SLGESGKTRV ETITGTTEGK
     TLAAGSAHTE ATTFSGGSGS TRAGPLGGAS GTSGGYVPGR ETEPTTSIEE TGTSRTIFKT
     VGITSAPGRQ AGTSVVAPST TVAPGSFSTA ATTSPGASGM TGVRTTSKTT TSLGGTGTTR
     TEIKSGATTG APGIKTDIMG ESSRTTILSG SSNTEATNSI EETGTSGTGF KTAGITAAPG
     KQAGTSGVAP GTTVAPGSFS TAATTSPGAS GVTGTGPTAE TTTFLGGSST TGAEIKSGAT
     TGAPGSKTGT AKVLSGTTVA SGSSNSEATT FSGITEAVTV PSKNGSMTTA LGSQLSSSQT
     VIPGSSGTIS HTTVAPGSSV TGTTTGASDD QVTGSKTGTT GVALSTTVAP GSSSTEATTS
     TGVHRTTVVG QKTGATTRGS AKQGTRSTIE ATTSFRGTGT TGSGMNTGTT GVVSGNTISP
     SSFNTEATSG TSERPNPGSE IGTTGIVSGT TVAPGSSNTE ATTSLGNGGT TEAGSKIVTT
     GITTGTTIVP GSFNTKATTS TDVGVATGVG MATGITNIIS GRSQPTGSKT GYTVTGSGTT
     ALPGGFRTGN TPGSTGVTSS QEGTTVVSSG ITGIPETSIS GPSKEASDKT TAPGPPTTVT
     ASTGVKETSE TGVQTGSTLV TAGVPTRPQV SQPETTVVAT REVETENKTE CLASLPPAPV
     CHGPLGEEKS PGDIWTANCH RGTCTDAKTI DCKPEECPSP PTCKTGEKLV KFQSNDTCCE
     IGYCEPRTCL FNNTDYEIGA SFDDPSNPCV SYSCKDTGFA AVVQDCPKQT WCAEANRIYD
     SKKCCYTCKN NCRSSLVNVT VIYSGCKKRV QMAKCTGECE KTAKYNYDIL LLEHSCLCCR
     EENYELRDIV LDCPDGSTIP YQYKHITTCS CLDICQLYTT FMYS
//
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