ID Q7ZT21_DANRE Unreviewed; 143 AA.
AC Q7ZT21; F6NMX6; F6P3M8;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 188.
DE SubName: Full=Embryonic alpha globin e1 {ECO:0000313|EMBL:AAP78902.1};
DE SubName: Full=Hbae1 protein {ECO:0000313|EMBL:AAI52155.1};
DE SubName: Full=Hemoglobin alpha embryonic-1 {ECO:0000313|EMBL:AAH71550.1};
DE SubName: Full=Hemoglobin embryonic subunit alpha {ECO:0000313|RefSeq:XP_001333555.1, ECO:0000313|RefSeq:XP_002661306.1};
DE SubName: Full=Hemoglobin, alpha embryonic 1.1 {ECO:0000313|Ensembl:ENSDARP00000092510, ECO:0000313|RefSeq:NP_891985.1};
DE SubName: Full=Novel alpha-globin {ECO:0000313|EMBL:CAE30446.1};
DE SubName: Full=Novel alpha-type globin {ECO:0000313|EMBL:CAD60790.1};
GN Name=hbae1.1 {ECO:0000313|Ensembl:ENSDARP00000092510,
GN ECO:0000313|ZFIN:ZDB-GENE-980526-80};
GN Synonyms=dZ118J2.6 {ECO:0000313|RefSeq:NP_891985.1}, hba2
GN {ECO:0000313|RefSeq:NP_891985.1}, HBA2r
GN {ECO:0000313|RefSeq:NP_891985.1}, HBAA1
GN {ECO:0000313|RefSeq:NP_891985.1}, hbae1
GN {ECO:0000313|RefSeq:NP_891985.1}, hbae1.2
GN {ECO:0000313|ZFIN:ZDB-GENE-170302-1}, hbae1.3
GN {ECO:0000313|ZFIN:ZDB-GENE-061207-39}, LOC100334599
GN {ECO:0000313|RefSeq:XP_002661306.1}, OTTDARP00000001843
GN {ECO:0000313|EMBL:CAD60790.1}, OTTDARP00000001846
GN {ECO:0000313|EMBL:CAD60793.1}, si:by119c3.1
GN {ECO:0000313|RefSeq:NP_891985.1}, si:by119c3.3
GN {ECO:0000313|RefSeq:NP_891985.1}, SI:dZ118J2.10
GN {ECO:0000313|RefSeq:NP_891985.1}, SI:dZ118J2.8
GN {ECO:0000313|RefSeq:NP_891985.1}, si:xx-119c3.3
GN {ECO:0000313|RefSeq:NP_891985.1}, wu:fa12a11
GN {ECO:0000313|RefSeq:NP_891985.1}, wu:fb74f06
GN {ECO:0000313|RefSeq:NP_891985.1}, zgc:86936
GN {ECO:0000313|RefSeq:NP_891985.1};
GN ORFNames=bY119C3.1-001 {ECO:0000313|EMBL:CAD60790.1}, bY119C3.3-001
GN {ECO:0000313|EMBL:CAD60793.1}, dZ118J2.10-001
GN {ECO:0000313|EMBL:CAE30448.1}, dZ118J2.8-001
GN {ECO:0000313|EMBL:CAE30446.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI52155.1};
RN [1] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9806542; DOI=10.1038/3049;
RA Brownlie A., Donovan A., Pratt S.J., Paw B.H., Oates A.C., Brugnara C.,
RA Witkowska H.E., Sassa S., Zon L.I.;
RT "Positional cloning of the zebrafish sauternes gene: a model for congenital
RT sideroblastic anaemia.";
RL Nat. Genet. 20:244-250(1998).
RN [2] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9671819;
RA Kwok C., Korn R.M., Davis M.E., Burt D.W., Critcher R., McCarthy L.,
RA Paw B.H., Zon L.I., Goodfellow P.N., Schmitt K.;
RT "Characterization of whole genome radiation hybrid mapping resources for
RT non-mammalian vertebrates.";
RL Nucleic Acids Res. 26:3562-3566(1998).
RN [3] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10515866;
RA Oates A.C., Brownlie A., Pratt S.J., Irvine D.V., Liao E.C., Paw B.H.,
RA Dorian K.J., Johnson S.L., Postlethwait J.H., Zon L.I., Wilks A.F.;
RT "Gene duplication of zebrafish JAK2 homologs is accompanied by divergent
RT embryonic expression patterns: only jak2a is expressed during
RT erythropoiesis.";
RL Blood 94:2622-2636(1999).
RN [4] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10417824;
RA Oates A.C., Wollberg P., Pratt S.J., Paw B.H., Johnson S.L., Ho R.K.,
RA Postlethwait J.H., Zon L.I., Wilks A.F.;
RT "Zebrafish stat3 is expressed in restricted tissues during embryogenesis
RT and stat1 rescues cytokine signaling in a STAT1-deficient human cell
RT line.";
RL Dev. Dyn. 215:352-370(1999).
RN [5] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11116087;
RA Ton C., Hwang D.M., Dempsey A.A., Tang H.C., Yoon J., Lim M., Mably J.D.,
RA Fishman M.C., Liew C.C.;
RT "Identification, characterization, and mapping of expressed sequence tags
RT from an embryonic zebrafish heart cDNA library.";
RL Genome Res. 10:1915-1927(2000).
RN [6] {ECO:0000313|EMBL:AAP78902.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12618133; DOI=10.1016/S0012-1606(02)00041-6;
RA Brownlie A., Hersey C., Oates A.C., Paw B.H., Falick A.M., Witkowska H.E.,
RA Flint J., Higgs D., Jessen J., Bahary N., Zhu H., Lin S., Zon L.;
RT "Characterization of embryonic globin genes of the zebrafish.";
RL Dev. Biol. 255:48-61(2003).
RN [7] {ECO:0000313|EMBL:AAP78902.1}
RP NUCLEOTIDE SEQUENCE.
RA Brownlie A.J., Zon L.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:CAD60790.1}
RP NUCLEOTIDE SEQUENCE.
RA Matthews L.;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AAI52155.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore local strain {ECO:0000313|EMBL:AAI55771.1};
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH71550.1}, and Larvae
RC {ECO:0000313|EMBL:AAI52155.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:CAE30446.1}
RP NUCLEOTIDE SEQUENCE.
RA Wray P.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|Ensembl:ENSDARP00000092510}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000092510};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [12] {ECO:0000313|Ensembl:ENSDARP00000092510, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000092510};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [13] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26138676;
RA Jia X.E., Ma K., Xu T., Gao L., Wu S., Fu C., Zhang W., Wang Z., Liu K.,
RA Dong M., Jing C., Ren C., Dong Z., Chen Y., Jin Y., Huang Q., Chang X.,
RA Deng M., Li L., Luo L., Zhu J., Dang Y., Chang H.C., Zon L.I., Zhou Y.,
RA Chen S., Pan W.;
RT "Mutation of kri1l causes definitive hematopoiesis failure via PERK-
RT dependent excessive autophagy induction.";
RL Cell Res. 25:946-962(2015).
RN [14] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26150473; DOI=10.1084/jem.20141286;
RA Rissone A., Weinacht K.G., la Marca G., Bishop K., Giocaliere E.,
RA Jagadeesh J., Felgentreff K., Dobbs K., Al-Herz W., Jones M.,
RA Chandrasekharappa S., Kirby M., Wincovitch S., Simon K.L., Itan Y.,
RA DeVine A., Schlaeger T., Schambach A., Sood R., Notarangelo L.D.,
RA Candotti F.;
RT "Reticular dysgenesis-associated AK2 protects hematopoietic stem and
RT progenitor cell development from oxidative stress.";
RL J. Exp. Med. 212:1185-1202(2015).
RN [15] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26361727;
RA Guarienti M., Giacopuzzi E., Gianoncelli A., Sigala S., Spano P.,
RA Pecorelli S., Pani L., Memo M.;
RT "Computational and functional analysis of biopharmaceutical drugs in
RT zebrafish: Erythropoietin as a test model.";
RL Pharmacol. Res. 102:12-21(2015).
RN [16] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26131719;
RA Gao L., Li D., Ma K., Zhang W., Xu T., Fu C., Jing C., Jia X., Wu S.,
RA Sun X., Dong M., Deng M., Chen Y., Zhu W., Peng J., Wan F., Zhou Y.,
RA Zon L.I., Pan W.;
RT "TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish
RT Definitive Hematopoiesis.";
RL PLoS Genet. 11:e1005346-e1005346(2015).
RN [17] {ECO:0000313|RefSeq:NP_891985.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26161877;
RA Seiler C., Gebhart N., Zhang Y., Shinton S.A., Li Y.S., Ross N.L., Liu X.,
RA Li Q., Bilbee A.N., Varshney G.K., LaFave M.C., Burgess S.M.,
RA Balciuniene J., Balciunas D., Hardy R.R., Kappes D.J., Wiest D.L.,
RA Rhodes J.;
RT "Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T
RT lymphocyte Development in Zebrafish.";
RL PLoS ONE 10:e0131908-e0131908(2015).
RN [18] {ECO:0000313|RefSeq:NP_891985.1, ECO:0000313|RefSeq:XP_001333555.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_001333555.1,
RC ECO:0000313|RefSeq:XP_002661306.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the globin family.
CC {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC ECO:0000256|RuleBase:RU000356}.
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DR EMBL; AL935210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC071550; AAH71550.1; -; mRNA.
DR EMBL; BC152154; AAI52155.1; -; mRNA.
DR EMBL; BC155770; AAI55771.1; -; mRNA.
DR EMBL; AY325264; AAP78902.1; -; mRNA.
DR EMBL; AL845551; CAD60790.1; -; Genomic_DNA.
DR EMBL; AL845551; CAD60793.1; -; Genomic_DNA.
DR EMBL; BX004811; CAE30446.1; -; Genomic_DNA.
DR EMBL; BX004811; CAE30448.1; -; Genomic_DNA.
DR RefSeq; NP_891985.1; NM_182940.2.
DR RefSeq; XP_001333555.1; XM_001333519.7.
DR RefSeq; XP_002661306.1; XM_002661260.5.
DR STRING; 7955.ENSDARP00000092510; -.
DR PaxDb; 7955-ENSDARP00000092510; -.
DR Ensembl; ENSDART00000101734.5; ENSDARP00000092510.4; ENSDARG00000088330.5.
DR Ensembl; ENSDART00000125092.4; ENSDARP00000107930.1; ENSDARG00000089475.6.
DR GeneID; 100334599; -.
DR GeneID; 30597; -.
DR GeneID; 572729; -.
DR KEGG; dre:30597; -.
DR AGR; ZFIN:ZDB-GENE-980526-80; -.
DR CTD; 100334599; -.
DR CTD; 30597; -.
DR CTD; 572729; -.
DR ZFIN; ZDB-GENE-980526-80; hbae1.1.
DR ZFIN; ZDB-GENE-170302-1; hbae1.2.
DR ZFIN; ZDB-GENE-061207-39; hbae1.3.
DR eggNOG; KOG3378; Eukaryota.
DR HOGENOM; CLU_003827_10_2_1; -.
DR OrthoDB; 2939502at2759; -.
DR TreeFam; TF332328; -.
DR Reactome; R-DRE-1237044; Erythrocytes take up carbon dioxide and release oxygen.
DR Reactome; R-DRE-1247673; Erythrocytes take up oxygen and release carbon dioxide.
DR Reactome; R-DRE-2168880; Scavenging of heme from plasma.
DR Reactome; R-DRE-9707564; Cytoprotection by HMOX1.
DR Reactome; R-DRE-9707616; Heme signaling.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000088330; Expressed in larva and 10 other cell types or tissues.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; Globins; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11442:SF48; HEMOGLOBIN SUBUNIT ALPHA; 1.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; Globin-like; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Heme {ECO:0000256|RuleBase:RU000356}; Iron {ECO:0000256|RuleBase:RU000356};
KW Metal-binding {ECO:0000256|RuleBase:RU000356};
KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621,
KW ECO:0000256|RuleBase:RU000356};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7ZT21};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transport {ECO:0000256|RuleBase:RU000356}.
FT DOMAIN 3..143
FT /note="Globin family profile"
FT /evidence="ECO:0000259|PROSITE:PS01033"
SQ SEQUENCE 143 AA; 15588 MW; 5B480E9B9C56800A CRC64;
MSLSAKDKAA VKTLWAKIAG KADDIGHDAL SRMLIVYPQT KTYFSHWKDL SPGSAPVRKH
GKTVMGGVAE AVSKIDDLNA GLLNLSELHA FQLRVDPANF KILSHNILVV LATLFPADFT
PEAHVAMDKF LSALALAMSE KYR
//
