ID Q7ZY98_XENLA Unreviewed; 906 AA.
AC Q7ZY98;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Staphylococcal nuclease domain-containing protein {ECO:0000256|PIRNR:PIRNR017179};
DE EC=3.1.31.1 {ECO:0000256|PIRNR:PIRNR017179};
GN Name=snd1.L {ECO:0000313|RefSeq:NP_001080500.1,
GN ECO:0000313|Xenbase:XB-GENE-6254060};
GN Synonyms=2e999 {ECO:0000313|RefSeq:NP_001080500.1}, snd1
GN {ECO:0000313|RefSeq:NP_001080500.1,
GN ECO:0000313|Xenbase:XB-GENE-6254060}, snd1-a
GN {ECO:0000313|RefSeq:NP_001080500.1}, snd1-b
GN {ECO:0000313|RefSeq:NP_001080500.1}, tdrd11
GN {ECO:0000313|RefSeq:NP_001080500.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH43884.1};
RN [1] {ECO:0000313|RefSeq:NP_001080500.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH43884.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH43884.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001080500.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Endonuclease that mediates miRNA decay of both protein-free
CC and AGO2-loaded miRNAs. {ECO:0000256|PIRNR:PIRNR017179}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-
CC phosphooligonucleotide end-products.; EC=3.1.31.1;
CC Evidence={ECO:0000256|PIRNR:PIRNR017179};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR017179}.
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DR EMBL; BC043884; AAH43884.1; -; mRNA.
DR RefSeq; NP_001080500.1; NM_001087031.1.
DR STRING; 8355.Q7ZY98; -.
DR PaxDb; 8355-Q7ZY98; -.
DR DNASU; 380192; -.
DR GeneID; 380192; -.
DR KEGG; xla:380192; -.
DR AGR; Xenbase:XB-GENE-6254060; -.
DR CTD; 380192; -.
DR Xenbase; XB-GENE-6254060; snd1.L.
DR OMA; EKTCCTV; -.
DR OrthoDB; 375531at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 380192; Expressed in pancreas and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016894; F:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters; IEA:UniProtKB-EC.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:InterPro.
DR CDD; cd00175; SNc; 4.
DR CDD; cd20433; Tudor_TDRD11; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002071; Thermonucl_AS.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047386; Tudor_TDRD11.
DR PANTHER; PTHR12302; EBNA2 BINDING PROTEIN P100; 1.
DR PANTHER; PTHR12302:SF2; STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00565; SNase; 4.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 4.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; Staphylococcal nuclease; 5.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS01284; TNASE_2; 1.
DR PROSITE; PS50830; TNASE_3; 4.
DR PROSITE; PS50304; TUDOR; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017179};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..162
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 189..324
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 337..492
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 521..656
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 725..783
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
SQ SEQUENCE 906 AA; 101281 MW; E2066B7434F46374 CRC64;
MASSGAQTGP VAPALQRGIV KMVLSGCAII VRGQPRGGPP PERQINLSNI RAGALARRAA
ASQQDSKDTP DEPWAFPARE FLRKKLIGKE VCFTVEYKTP QGREYGTVYL GKDTSGENIA
ESLVAEGLAS RREGVRANTP EQSRLAELEE QARSAKKGVW SEGTGSHTVR DVKYTIENPR
HFVDSMHQKP VNAVIEHVRD GSVVRALLLP DCYLVTVMLS GIKCPTFKRE ADGTESPEAF
AAEAKFFTES RLLQRDVQII LESCHNQNIL GTILHPNGNI TELLLKEGFA RCVDWSIAVY
TQGSEKLRAA ERFAKEHKTR IWRDYVAPTA NLDQKDKQFV AKVVQILNAD AMVVKLNSGD
YKTIHLSSIR PPRLEGEGAQ DKNKKLRPLY DIPYMFEARE FLRKKLIGKK VNVNVDYIRS
ASTATETVPA FSERTCATVT IGGINIAEAL VSKGLATVIR YRQDDDQRSS HYDELLAAEA
RAIKNAKGLH SKKEVPIHRV ADISGDTQKA KQFLPFLQRA GRSEAVVEYV FSGSRLKLYM
PKETCLITFL LAGIECPRGS RNMPSGVQEG EPFSEEAMLF TKELVLQREV EVEVEAMDKA
GNFIGWLHID GVNISVALVE HALSKVHFTA ERSNYYKTLL AAEEGPKQRK EKVWSKFEEQ
PVEEVVTVVE EKERNANYKP VLVTEITDEL HFYIQDVETG TQLEKLMESM RSEIASNPPL
EGSFSPRRGD YCIAKYMDGE WYRARVEKVE STAKVHVFYI DYGNREVLPS TRLGTLPQSF
SISTLPAQAI EYCFAFIQVP ADEDARADVV DNVVRDIQNT QCLLNVEYSG AGCPHVTLQF
TDSKDDVGLG LVKEGLVMVE VRKEKQFHKL IGEYVAAQES AKAARLNLWR YGDFRADDAA
EFGYSR
//
