ID Q80ZR8_MOUSE Unreviewed; 219 AA.
AC Q80ZR8;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=RIKEN cDNA 1700001J03 gene {ECO:0000313|Ensembl:ENSMUSP00000073399.6};
GN Name=1700001J03Rik {ECO:0000313|EMBL:AAH48528.1,
GN ECO:0000313|Ensembl:ENSMUSP00000073399.6,
GN ECO:0000313|MGI:MGI:1916532};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH48528.1};
RN [1] {ECO:0000313|EMBL:AAH48528.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000313|EMBL:AAH48528.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000073399.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000073399.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000073399.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000073399.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC048528; AAH48528.1; -; mRNA.
DR RefSeq; NP_001008547.1; NM_001008547.1.
DR STRING; 10090.ENSMUSP00000073399; -.
DR PaxDb; 10090-ENSMUSP00000073399; -.
DR DNASU; 69282; -.
DR Ensembl; ENSMUST00000073721.7; ENSMUSP00000073399.6; ENSMUSG00000095040.3.
DR GeneID; 69282; -.
DR KEGG; mmu:69282; -.
DR UCSC; uc009ana.1; mouse.
DR AGR; MGI:1916532; -.
DR MGI; MGI:1916532; 1700001J03Rik.
DR VEuPathDB; HostDB:ENSMUSG00000095040; -.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000155423; -.
DR HOGENOM; CLU_112704_0_0_1; -.
DR OrthoDB; 4811600at2759; -.
DR TreeFam; TF339069; -.
DR BioGRID-ORCS; 69282; 1 hit in 78 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000095040; Expressed in spermatid and 45 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR PANTHER; PTHR46793:SF1; 1700018F24RIK PROTEIN-RELATED; 1.
DR PANTHER; PTHR46793; 1700018F24RIK PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 58..182
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
SQ SEQUENCE 219 AA; 25676 MW; E6346D21153DEE37 CRC64;
MFSCFQGSRG SSHKKAKSGF LVRFWRRLIR PLSHFRHASH SEPKVCSQNE QEPDCMPRRP
RFNYNSPEYV VQMIHYIPAA VQHNDHVCIR IFLAMYPSYA STWKVLDLLM TTYASFRPDC
VEDQQTKSDV FSFLFHWFKK FPKDFCESPD LDVVRQFIDY VRRNVPSADE DTQARELLSV
LEEQEAIALN TEEVVQSTYV LPMDCIFETN RLISEMGPS
//
