ID Q812A7_MESAU Unreviewed; 333 AA.
AC Q812A7;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Cathepsin L {ECO:0000313|EMBL:AAO33585.1, ECO:0000313|RefSeq:NP_001268616.1};
GN Name=Ctsv {ECO:0000313|RefSeq:NP_001268616.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|EMBL:AAO33585.1};
RN [1] {ECO:0000313|EMBL:AAO33585.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Placenta {ECO:0000313|EMBL:AAO33585.1};
RA Frenck J., Sol-Church K.;
RT "Gerbil and Hamster Homologs of Mouse Cathepsin P.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001268616.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18463158; DOI=10.1093/molehr/gan026;
RA Sireesha G.V., Mason R.W., Hassanein M., Tonack S., Navarrete Santos A.,
RA Fischer B., Seshagiri P.B.;
RT "Role of cathepsins in blastocyst hatching in the golden hamster.";
RL Mol. Hum. Reprod. 14:337-346(2008).
RN [3] {ECO:0000313|RefSeq:NP_001268616.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [4] {ECO:0000313|RefSeq:NP_001268616.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF479267; AAO33585.1; -; mRNA.
DR RefSeq; NP_001268616.1; NM_001281687.1.
DR STRING; 10036.ENSMAUP00000000845; -.
DR MEROPS; C01.032; -.
DR GeneID; 101825242; -.
DR KEGG; maua:101825242; -.
DR CTD; 1515; -.
DR eggNOG; KOG1543; Eukaryota.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001268616.1};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..333
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001268616.1"
FT /id="PRO_5009993619"
FT DOMAIN 29..88
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 114..332
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 333 AA; 37234 MW; 14ABC90DA01A9A5F CRC64;
MNLLLLLATL CLGTASATPK FNQTFNAQWH KWKSTHRRLY DTNEEEWRRA VWEKNMKMIE
LHNGEYSEGK HGFTMEMNAF GDMTNEEFRQ LVNGYKHQKH RKGKLFQEPL MLQLPKSVDW
REKGCVTPVK NQGQCGSCWA FSACGALEGQ MCLKTGVLVS LSEQNLVDCS RGEGNQGCNG
GLMDFAFQYV LNNKGLDSEE SYPYEAKDGT CKYKPEFAAA NDTGYVDIPQ LEKALMKAVA
TVGPIAVAID ASHPSFQFYS SGIYFEPNCS SKDLDHGVLV IGYGFEGTDS NKKKYWIVKN
SWGTGWGMGG FFHIAKDKNN HCGIATAASY PTV
//
