ID FPUC_BACAN Reviewed; 272 AA.
AC Q81LM1; E9QQN5; E9QQN6; Q6HT27; Q6KMB6;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 161.
DE RecName: Full=Petrobactin import ATP-binding protein FpuC {ECO:0000305};
DE EC=7.2.2.- {ECO:0000305|PubMed:22429808};
GN Name=fpuC {ECO:0000303|PubMed:22429808};
GN OrderedLocusNames=GBAA_4595 {ECO:0000312|EMBL:AAT33716.1};
OS Bacillus anthracis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [2]
RP FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=Sterne;
RX PubMed=22429808; DOI=10.1111/j.1365-2958.2012.08028.x;
RA Dixon S.D., Janes B.K., Bourgis A., Carlson P.E. Jr., Hanna P.C.;
RT "Multiple ABC transporters are involved in the acquisition of petrobactin
RT in Bacillus anthracis.";
RL Mol. Microbiol. 84:370-382(2012).
CC -!- FUNCTION: Part of an ABC transporter complex involved in ferric-
CC petrobactin uptake. Probably responsible for energy coupling to the
CC transport system. {ECO:0000269|PubMed:22429808}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-
CC siderophore(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:15597,
CC Rhea:RHEA-COMP:11342, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29034, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000305|PubMed:22429808};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FpuC),
CC two transmembrane proteins (FpuB) and a solute-binding protein (FpuA).
CC {ECO:0000305|PubMed:22429808}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:22429808};
CC Peripheral membrane protein {ECO:0000305|PubMed:22429808}; Cytoplasmic
CC side {ECO:0000305|PubMed:22429808}.
CC -!- DISRUPTION PHENOTYPE: A mutant lacking fatE, fpuC and fpuD ATPases is
CC deficient in petrobactin import in iron-depleted conditions.
CC {ECO:0000269|PubMed:22429808}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AE017334; AAT33716.1; -; Genomic_DNA.
DR RefSeq; WP_000626544.1; NZ_VLYO01000001.1.
DR AlphaFoldDB; Q81LM1; -.
DR SMR; Q81LM1; -.
DR STRING; 261594.GBAA_4595; -.
DR DNASU; 1088621; -.
DR GeneID; 45024240; -.
DR KEGG; bar:GBAA_4595; -.
DR PATRIC; fig|1392.230.peg.4533; -.
DR HOGENOM; CLU_000604_1_11_9; -.
DR OMA; RCWIAMA; -.
DR OrthoDB; 9787851at2; -.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR CDD; cd03214; ABC_Iron-Siderophores_B12_Hemin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR42771:SF11; FERRICHROME TRANSPORT ATP-BINDING PROTEIN FHUC; 1.
DR PANTHER; PTHR42771; IRON(3+)-HYDROXAMATE IMPORT ATP-BINDING PROTEIN FHUC; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell membrane; Ion transport; Iron; Iron transport; Membrane;
KW Nucleotide-binding; Reference proteome; Translocase; Transport.
FT CHAIN 1..272
FT /note="Petrobactin import ATP-binding protein FpuC"
FT /id="PRO_0000443818"
FT DOMAIN 2..238
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 272 AA; 30996 MW; 8E221D413E734893 CRC64;
MISVNKVFYA HSERFQMQNM NVHIKAGEVV SLIGPNGSGK STLLRLMARL LKQSEGDIVL
DGKSIHTMKS ADVAKQLAML PQMHDHQLDL TVKELIEFGR GPHKSWRGRL NKEDEEIVDW
ALSVTNLEGY EYRLLQSLSG GERQRAWIAM TLAQRTNVLL LDEPTTFLDI VHQLEVMELV
KRLNEEFGMT IIMVLHDINQ AAQYSDRLLV LKRGKLQYDG VPEEVLCHEM FQHIFGIEVD
IFQGSEKPFF TPKRISKKGG AKCEQKNVLP LS
//
