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Database: UniProt
Entry: Q821H8
LinkDB: Q821H8
Original site: Q821H8 
ID   UVRB_CHLCV              Reviewed;         656 AA.
AC   Q821H8;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   16-OCT-2019, entry version 103.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=CCA_00962;
OS   Chlamydophila caviae (strain ATCC VR-813 / DSM 19441 / GPIC)
OS   (Chlamydia caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B.,
RA   Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J.,
RA   White O., Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G.,
RA   Bavoil P.M., Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; AE015925; AAP05701.1; -; Genomic_DNA.
DR   RefSeq; WP_011006914.1; NC_003361.3.
DR   SMR; Q821H8; -.
DR   STRING; 227941.CCA_00962; -.
DR   PRIDE; Q821H8; -.
DR   EnsemblBacteria; AAP05701; AAP05701; CCA_00962.
DR   KEGG; cca:CCA_00962; -.
DR   eggNOG; ENOG4105CCW; Bacteria.
DR   eggNOG; COG0556; LUCA.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   OrthoDB; 95696at2; -.
DR   BioCyc; CCAV227941:G1G03-978-MONOMER; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; SOS response.
FT   CHAIN         1    656       UvrABC system protein B.
FT                                /FTId=PRO_0000138384.
FT   DOMAIN       24    409       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      426    589       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      616    651       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      37     44       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF        90    113       Beta-hairpin.
SQ   SEQUENCE   656 AA;  74398 MW;  CDEB6B64936683AC CRC64;
     MTFELRAAFA PCGDQPEAIA KLTQGIRNDV QSQVLLGTTG SGKTFTIANV VANVNRPTLV
     LAHNKTLAAQ LYQEFKEFFP NNAVEYFISY YDYYQPEAYI ARNDTYIEKS LLINSEIDKL
     RLSATRSILE RRDTLIVSSV SCIYGIGSPE NYASMALELK VGKEYPRTLL AAQLVKMNYQ
     ASPVAQRSTF RERGSVIDIF PAYESDQAIR LEFFNDTLSS IEYSDPLTMI PTASVASTII
     YPGSHYVTPE AVREQAICSI REELEERMLF FHDRPVEQDR LFHRTTHDIE MIKETGFCKG
     IENYSRHFTK MPPGAPPACL LDYFPEDFLL VIDESHQTLP QIRAMYRGDL SRKQSLVEYG
     FRLPSAYDNR PLTYEEAQKY FHNVIYVSAT PGETELNESQ GHIVEQIIRP TGIPDPIPEI
     RPATGQVDDL LEEIRKRLSK SQEKILVISI TKKLAEDIAA FLSELDIAAA YLHSGIETAE
     RTRILADLRL GNIDVLIGVN LLREGLDLPE VSLVAILDAD KEGFLRSTSS LIQFCGRAAR
     NVEGKVIFYA DQKTRSIEQT LKETERRRQI QLDYNKANNI TPKPIIKAIF ANPIPQGGKK
     ESQEPAKTPL SIKELEKLIK KFENLMQEAA HEFRFDEAAK YRDKMKAAKE QLLYLS
//
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