ID   Q82CE5_STRAW            Unreviewed;       596 AA.
AC   Q82CE5;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   SubName: Full=Secreted protein {ECO:0000313|EMBL:BAC73117.1};
GN   ORFNames=SAVERM_5405 {ECO:0000313|EMBL:BAC73117.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC73117.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC73117.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC73117.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000030; BAC73117.1; -; Genomic_DNA.
DR   RefSeq; WP_010986808.1; NZ_JZJK01000066.1.
DR   AlphaFoldDB; Q82CE5; -.
DR   KEGG; sma:SAVERM_5405; -.
DR   eggNOG; COG1409; Bacteria.
DR   HOGENOM; CLU_033055_0_0_11; -.
DR   OrthoDB; 8132905at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.30.750.180; GpdQ, beta-strand dimerisation domain; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR042281; GpdQ_beta-strand.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR022506; Metallophosphoesterase_PPA1498.
DR   InterPro; IPR006311; TAT_signal.
DR   NCBIfam; TIGR03767; P_acnes_RR; 1.
DR   PANTHER; PTHR43143; METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY; 1.
DR   PANTHER; PTHR43143:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE CPPED1; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..596
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004297304"
FT   DOMAIN          263..492
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
SQ   SEQUENCE   596 AA;  63292 MW;  663DB15B1FC0BA51 CRC64;
     MSRIRSVAAA TATAAHAAAG ALDRRSLLAA TGAVSLSAGL GFALRPGSEV PAPAHAATGE
     ALAVSRQAPA APLAPYTRGT TLSSVAAARS GSSGYRRLGD GAAWKRVVRG DLATPKAGRA
     GRRTALASFV QFTDLHLVDV QHPLRYEYLR SQTASAWRPQ ESLSVAGAVS LVERVNALRG
     APVTGTPLHF VMTTGDNTDN NSKTELDWFL KVMSGGRVTP NSGDPRHYEG VQSSGLKLYW
     QPDAALRDAD KQLGFPRIQG FLAAAIRELR SPGLNLPWYS TVGNHDALPG GCYAPGDSYF
     AEVAVGGKKL MTLDQAAGKA IWDNVKKGGD PKGVDFKAML KSQARHMRSV TPDEARAPFT
     PAEYLKAHLD PAHTGPGPIG HGYSEANLSA GTQYYVFRIA DDVLGISLDT TDPGGHYEGS
     IGTAQLKWLE KTLRDNKDSY VIVFSHHTSK TMRNLNTDPA HPGEKRHGGA ELVSVLGNHP
     NVAAWVNGHS HKNDITAHAA PNKGSKGAFW EISTASHVDF PQLARIIELV DNKDGTISLF
     TTLIESAAPH RTDFADLTQT GLAALYRELG FNAPGARSTL SGTAEDRNTE LVLTKG
//