ID Q82FT6_STRAW Unreviewed; 589 AA.
AC Q82FT6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:BAC71878.1};
GN ORFNames=SAVERM_4166 {ECO:0000313|EMBL:BAC71878.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC71878.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC71878.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC71878.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BA000030; BAC71878.1; -; Genomic_DNA.
DR AlphaFoldDB; Q82FT6; -.
DR KEGG; sma:SAVERM_4166; -.
DR eggNOG; COG1276; Bacteria.
DR eggNOG; COG2372; Bacteria.
DR HOGENOM; CLU_023176_0_0_11; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR GO; GO:0046688; P:response to copper ion; IEA:InterPro.
DR Gene3D; 2.60.40.1220; -; 1.
DR InterPro; IPR032694; CopC/D.
DR InterPro; IPR007348; CopC_dom.
DR InterPro; IPR008457; Cu-R_CopD_dom.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR34820; INNER MEMBRANE PROTEIN YEBZ; 1.
DR PANTHER; PTHR34820:SF4; INNER MEMBRANE PROTEIN YEBZ; 1.
DR Pfam; PF04234; CopC; 1.
DR Pfam; PF05425; CopD; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..84
FT /note="CopC"
FT /evidence="ECO:0000259|Pfam:PF04234"
FT DOMAIN 277..351
FT /note="Copper resistance protein D"
FT /evidence="ECO:0000259|Pfam:PF05425"
FT REGION 364..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 60521 MW; 72C06A5C5215A929 CRC64;
MLKKAPAAIT LTFTESVGLL DDSFRVLDPE NRRVHIGEPQ HAGGRSETAR VTLPDDMGTG
TFTVGWRVVS ADSHPVSGAL TFSIGKPSAT TAVIPTQAAG DTASATLYDI ARYFAYGGLA
LLLGTMVFSL VTGVEAARGL LLTGWWTLLA STIALLLLRG PYERGGGPAA AFDPSVLAET
ATSRPGVTLL VRLVLLAGAA FFPVRAGGRW WKAGGGLLTL ALAGTWAAAE HASAGVQVPV
AMVSAVLHLL AMAAWLGGLA ALLTALYRAP EELPASAVTR FSRLALTAVT VLVATGVYQS
WRGLGSLDAL ATTSYGRLLV AKLVAVLLLL AAATYSRRWT ARLAAPVERR ADVRERVLEP
VGAAADAEVS GTDTSAGTGT DTSAGTGTGT GSDSGAETGT GTETGSDTAT ETGPQSGPLP
PTAGGDPGAY RRGLRRSVLA EAIVAIVVLV ITTLLTGTQP GRAATEAAAS AAEAARPMAS
TTVIPFDVGT PGGHGKIQIE LTPGRVGENS VQAVIFGPDG GLATVPELRL TFTLEKQDIG
PLDAKLADRG GYWTSDTLNL PLPGTWTMKA TVRTTDIDQI TVSRTVRIE
//
