ID Q82L35_STRAW Unreviewed; 276 AA.
AC Q82L35;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Methyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=SAVERM_2177 {ECO:0000313|EMBL:BAC69888.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC69888.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC69888.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC69888.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
RN [3] {ECO:0007829|PDB:3GIW}
RP X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).
RG Joint Center for Structural Genomics (JCSG);
RT "Crystal structure of Rossmann-fold protein of unknown function (DUF574)
RT (NP_823353.1) from Streptomyces avermitilis MA-4680 at 1.45 A resolution.";
RL Submitted (MAR-2009) to the PDB data bank.
RN [4] {ECO:0007829|PDB:3GO4}
RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH
RP S-ADENOSYL-L-HOMOCYSTEINE.
RG Joint Center for Structural Genomics (JCSG);
RT "Crystal structure of Rossmann-fold protein of unknown function (DUF574)
RT (NP_823353.1) from Streptomyces avermitilis MA-4680 at 1.80 A resolution.";
RL Submitted (MAR-2009) to the PDB data bank.
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DR EMBL; BA000030; BAC69888.1; -; Genomic_DNA.
DR PDB; 3GIW; X-ray; 1.45 A; A=1-276.
DR PDB; 3GO4; X-ray; 1.80 A; A=1-276.
DR PDBsum; 3GIW; -.
DR PDBsum; 3GO4; -.
DR AlphaFoldDB; Q82L35; -.
DR SMR; Q82L35; -.
DR DNASU; 1213589; -.
DR KEGG; sma:SAVERM_2177; -.
DR eggNOG; COG3315; Bacteria.
DR HOGENOM; CLU_067079_1_0_11; -.
DR EvolutionaryTrace; Q82L35; -.
DR Proteomes; UP000000428; Chromosome.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR006764; SAM_dep_MeTrfase_SAV2177_type.
DR Pfam; PF04672; Methyltransf_19; 1.
DR PIRSF; PIRSF017393; MTase_SAV2177; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3GIW, ECO:0007829|PDB:3GO4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT BINDING 27
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:3GO4"
FT BINDING 61
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:3GO4"
FT BINDING 62
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:3GO4"
FT BINDING 111
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:3GO4"
FT BINDING 138
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:3GO4"
FT BINDING 139
FT /ligand="S-adenosyl-L-homocysteine"
FT /ligand_id="ChEBI:CHEBI:57856"
FT /evidence="ECO:0007829|PDB:3GO4"
SQ SEQUENCE 276 AA; 30188 MW; FB32A6B0AE7A4761 CRC64;
MGGAALPDNG WPADRIDTES AHSARIYDYI IGGKDYYPAD KEAGDAMSRE WPALPVHMRA
NRDWMNRAVA HLAKEAGIRQ FLDIGTGIPT SPNLHEIAQS VAPESRVVYV DNDPIVLTLS
QGLLASTPEG RTAYVEADML DPASILDAPE LRDTLDLTRP VALTVIAIVH FVLDEDDAVG
IVRRLLEPLP SGSYLAMSIG TAEFAPQEVG RVAREYAARN MPMRLRTHAE AEEFFEGLEL
VEPGIVQVHK WHPDAATADG IRDEDIAMYG AVARKP
//
