ID Q82LH7_STRAW Unreviewed; 936 AA.
AC Q82LH7;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE SubName: Full=LuxR-family transcriptional regulator {ECO:0000313|EMBL:BAC69744.1};
GN ORFNames=SAVERM_2033 {ECO:0000313|EMBL:BAC69744.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC69744.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC69744.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC69744.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
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DR EMBL; BA000030; BAC69744.1; -; Genomic_DNA.
DR AlphaFoldDB; Q82LH7; -.
DR KEGG; sma:SAVERM_2033; -.
DR eggNOG; COG2197; Bacteria.
DR HOGENOM; CLU_006850_4_0_11; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT DOMAIN 869..934
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT COILED 779..806
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 936 AA; 99699 MW; 58F1A2BB2258A467 CRC64;
MTVRRDFKEP ARPRPDLVIG REELFAGARE QLTRGGSVLV HGPAGIGKST ILRALVTEYG
ETAHTVLRCS STESESHLPF LALADLLGLV EDEVLDRLPA PQRTALESAL TGRGESTLQR
DGLALRLAVL STLRVLAARG PVLIVADDLQ WLDPASAELL GFAARRLGGM PVQMLCAVRT
DTEPQGQQHD RYLRASPPET LAVRVNPLSR AQTAELLGRR GHTDLPRSTV RDIHRTSGGN
PLFALELGRA LAESPTPPSP GEPLPVPTSL RALVLNRLDM LSPQARRTLL VASAGARPTL
ALLHAAGREN AEAETAQAAA LGLLVTERDA PGVRFAHPLV SAALYAEATA QERRAAHAAL
STAASDPIER ARHLALATTG TDPRVATRLG EAAAVARDRG APSVAAGLGL LAARHTPADT
VPGPDERRLQ AAEDALTAGE TDLARDIARE VLGRAGGPAD RVRAWMVVID AAGQAMAEVD
AVFPQALADA GDDPRLLALV HYQLAWRALL VEGEFDKARE EAARSAELAA RAADRRAELL
ALAFQAQMET LMGHPDAPGT IKRALKEPQD PRVACDHNGA GAARFRWLIM GDQLAEARTT
ISALLREVRR RGMVESEVHF LRALAEVELR AGHCGRALDL ARESLRLARD TGIGEGATAM
FTSLAEAAGG EVNRALTLAR EAVGRAEEDG DLVYLSRALG ALGHAQLVAG DAAGAVRSLR
RVRELEEGLG VTDPARGRWH GDLAEALVRI GEPAEAQGFI DTTRTQALRL GRESVLAVLD
RAEALARAAR GEIDAATRQL TSAQDRLAKL GYGLEEARAA FALAGLRTHR PGPTSYDEAA
RLFRRCRALP WLRQVETATV TGPAQPALST AALDALAATE RQVAALVMEG ATNREIAARL
FISVKTVEAT LTRVYRKLGI RSRVDIVRLA AGGRQG
//
