ID Q82ZA3_ENTFA Unreviewed; 710 AA.
AC Q82ZA3;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=hexB {ECO:0000313|EMBL:AAO82840.1};
GN Synonyms=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN OrderedLocusNames=EF_3166 {ECO:0000313|EMBL:AAO82840.1};
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185 {ECO:0000313|EMBL:AAO82840.1, ECO:0000313|Proteomes:UP000001415};
RN [1] {ECO:0000313|EMBL:AAO82840.1, ECO:0000313|Proteomes:UP000001415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583 {ECO:0000313|Proteomes:UP000001415};
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D.,
RA Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L., Brinkac L., Beanan M., Daugherty S., DeBoy R.T.,
RA Durkin S., Kolonay J., Madupu R., Nelson W., Vamathevan J., Tran B.,
RA Upton J., Hansen T., Shetty J., Khouri H., Utterback T., Radune D.,
RA Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; AE016830; AAO82840.1; -; Genomic_DNA.
DR RefSeq; NP_816770.1; NC_004668.1.
DR RefSeq; WP_002378991.1; NZ_KE136524.1.
DR AlphaFoldDB; Q82ZA3; -.
DR STRING; 226185.EF_3166; -.
DR EnsemblBacteria; AAO82840; AAO82840; EF_3166.
DR KEGG; efa:EF3166; -.
DR PATRIC; fig|226185.45.peg.412; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000001415}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 521..663
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 348..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 79227 MW; 42B40F7370F839B7 CRC64;
MGKIQELSEQ LANQIAAGEV VERPASVVKE LVENALDAGS TQIDIFIEEA GLKTIQIIDN
GEGIAKEDVL NAFKRHATSK IHTRDDLFRI RSLGFRGEAL PSIASVSEMI VETATAEEEE
GSYVILKGGK VEENRPAALR KGTKMTVSNL FYNTPARLKY VKTIQTELAN IGDIVNRLAL
SHPKVAFRLV HDGHKMMSTT GNGDLKQTIA GIYGISTAKK MLKIEGKDLD FTLTGYVSLP
EVTRASRNYL STIINGRYIK NFALNKAIVA GYGSKLMVGR FPIAVLEIEM DPLLVDVNVH
PTKQEVRLSK EKDLMALIEQ AIQEVLSQEQ LIPNAADNLR FKKKLPPEPK AEQMEIPLST
EQPAVKQRPG SLSYNPATGR FYAEHATDET PASSAPEAVN QTERAVDPMD DPFAPPVPES
TSVAEETSAY ETSSAAADSA NHWETASNEQ QVIAEETKIT EVPDSEPSLR SSEAADEVFQ
EEMKLHPEFD ANSAASQREL KQALNKLEEE RPTERFPELE YFGQMHGTYL FAQSKDGLFI
IDQHAAQERI KYEYFREKIG EVSDDLQELL VPIVIDYPNS DALKIKEQKE TLAEVGIHLE
DFGQNSFIVR AHPTWYPAGE EESIVREMID MLLTTGSVSV KKFREATAIM MSCKRSIKAN
HYLNEQQARV LLKDLALCEN PFNCPHGRPV LIHFTNSDME RMFKRIQDPH
//
