ID Q831D6_ENTFA Unreviewed; 314 AA.
AC Q831D6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=Carbamate kinase {ECO:0000256|ARBA:ARBA00013070, ECO:0000256|PIRNR:PIRNR000723};
GN Name=arcC-4 {ECO:0000313|EMBL:AAO82286.1};
GN OrderedLocusNames=EF_2575 {ECO:0000313|EMBL:AAO82286.1};
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185 {ECO:0000313|EMBL:AAO82286.1, ECO:0000313|Proteomes:UP000001415};
RN [1] {ECO:0000313|EMBL:AAO82286.1, ECO:0000313|Proteomes:UP000001415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583 {ECO:0000313|Proteomes:UP000001415};
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D.,
RA Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L., Brinkac L., Beanan M., Daugherty S., DeBoy R.T.,
RA Durkin S., Kolonay J., Madupu R., Nelson W., Vamathevan J., Tran B.,
RA Upton J., Hansen T., Shetty J., Khouri H., Utterback T., Radune D.,
RA Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000228};
CC -!- PATHWAY: Metabolic intermediate metabolism; carbamoyl phosphate
CC degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005118}.
CC -!- SIMILARITY: Belongs to the carbamate kinase family.
CC {ECO:0000256|ARBA:ARBA00011066, ECO:0000256|PIRNR:PIRNR000723}.
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DR EMBL; AE016830; AAO82286.1; -; Genomic_DNA.
DR RefSeq; NP_816216.1; NC_004668.1.
DR RefSeq; WP_002367131.1; NZ_KE136528.1.
DR AlphaFoldDB; Q831D6; -.
DR STRING; 226185.EF_2575; -.
DR EnsemblBacteria; AAO82286; AAO82286; EF_2575.
DR KEGG; efa:EF2575; -.
DR PATRIC; fig|226185.45.peg.977; -.
DR eggNOG; COG0549; Bacteria.
DR HOGENOM; CLU_076278_0_0_9; -.
DR UniPathway; UPA00996; UER00366.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0008804; F:carbamate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0035975; P:carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04235; AAK_CK; 1.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR003964; Carb_kinase.
DR NCBIfam; TIGR00746; arcC; 1.
DR PANTHER; PTHR30409; CARBAMATE KINASE; 1.
DR PANTHER; PTHR30409:SF1; CARBAMATE KINASE-RELATED; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR PIRSF; PIRSF000723; Carbamate_kin; 1.
DR PRINTS; PR01469; CARBMTKINASE.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001415};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000723}.
FT DOMAIN 3..284
FT /note="Aspartate/glutamate/uridylate kinase"
FT /evidence="ECO:0000259|Pfam:PF00696"
SQ SEQUENCE 314 AA; 33951 MW; F04A1D038CD23B16 CRC64;
MGKRVVVALG GNALGNNLTE QMTAVKQTSK AIADLIEAGY EVILSHGNGP QVGMIQLAME
EFSFNNPQYP VVPLSMCVAM SQSYIGYDLE NALQEELRQR NISKAVTTVV TQVVVDENDP
AFKKPTKPIG RFMTKEEAEQ LVKEKNIQVM EDAGRGYRQV VASPKPKNIV ELLTIQTLVD
AGQTVIAGGG GGIPVIQEGN RLKGVNAVID KDFCSERLAE QVDADLLVIL TAVEKVCINF
GKENQEALGN VSTEKMKQYA QEGQFAPGSM LPKVEAAIKF AESKPGRKTL ITLLEKAKEG
LSGKTGTLIE NKES
//
