ID   Q836S5_ENTFA            Unreviewed;       729 AA.
AC   Q836S5;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   SubName: Full=6-aminohexanoate-cyclic-dimer hydrolase, putative {ECO:0000313|EMBL:AAO80836.1};
GN   OrderedLocusNames=EF_1033 {ECO:0000313|EMBL:AAO80836.1};
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185 {ECO:0000313|EMBL:AAO80836.1, ECO:0000313|Proteomes:UP000001415};
RN   [1] {ECO:0000313|EMBL:AAO80836.1, ECO:0000313|Proteomes:UP000001415}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583 {ECO:0000313|Proteomes:UP000001415};
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D.,
RA   Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L., Brinkac L., Beanan M., Daugherty S., DeBoy R.T.,
RA   Durkin S., Kolonay J., Madupu R., Nelson W., Vamathevan J., Tran B.,
RA   Upton J., Hansen T., Shetty J., Khouri H., Utterback T., Radune D.,
RA   Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
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DR   EMBL; AE016830; AAO80836.1; -; Genomic_DNA.
DR   RefSeq; NP_814766.1; NC_004668.1.
DR   AlphaFoldDB; Q836S5; -.
DR   STRING; 226185.EF_1033; -.
DR   EnsemblBacteria; AAO80836; AAO80836; EF_1033.
DR   KEGG; efa:EF1033; -.
DR   PATRIC; fig|226185.9.peg.966; -.
DR   eggNOG; COG0154; Bacteria.
DR   HOGENOM; CLU_009600_12_1_9; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1300.10; Amidase signature (AS) domain; 1.
DR   InterPro; IPR000120; Amidase.
DR   InterPro; IPR020556; Amidase_CS.
DR   InterPro; IPR023631; Amidase_dom.
DR   InterPro; IPR036928; AS_sf.
DR   PANTHER; PTHR11895:SF180; AMIDASE AMIC-RELATED; 1.
DR   PANTHER; PTHR11895; TRANSAMIDASE; 1.
DR   Pfam; PF01425; Amidase; 1.
DR   SUPFAM; SSF75304; Amidase signature (AS) enzymes; 1.
DR   PROSITE; PS00571; AMIDASES; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAO80836.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001415};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        706..724
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          111..540
FT                   /note="Amidase"
FT                   /evidence="ECO:0000259|Pfam:PF01425"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        552..632
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..680
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   729 AA;  78078 MW;  F20F0FC302F7176F CRC64;
     MLAQESILET TVQTETESVT TETSQTVANL ESETTSQTVM QEKESSSAIA ESSSGNAVAV
     TTETTNEIQN SDTDGKAVSA ESVFSEADYK QATALELATL VREKKVTSEE LVKIALAITK
     RENPTLNAVI TLREEAALTE AKALQDTGQP FLGVPLLLKG LGQSLKGESN TNGFGFLQDQ
     VAGGTSTFVK ALQNAGFIII GQTNYPELGW KNISDSKLYG VSVNPWNPNH YSGGSSGGAG
     ASVAAAFVPI ASGSDAGGSI RIPASWTGTV GLKPSRGVII GNSNSAKGQT VHFGLSRTVA
     DTNALFETLL TKKDLPAGHL SQAQPIAYTT ESPAGTPISA EAKEAVAEAV AFLKDQGYTL
     VEVKHPVDGE RLMKNYYTVA AGSAGIADFM ARQKLKRPLE RNDVELLTWA LFQTGKNITS
     EETTAAWTDI ALQAQAMDEF YQQYPILLTP TTAATAPSID NPLLKPEHAA QMEKIDQLSP
     AEQKQLIYDQ WLTAFTYTPF TQQANLFGHP ALSVPTYVSK EGLPLGIQFN SALNEDRTLL
     QLGALFENNH KINQPHVEEP DKDKEPDTSG EPDKDKEPNA SGELDKDKDP DASGEPDKDK
     DPDASGEPDK DKELDTSGEP DKDKETKTSE GPIEGKDQNQ NQNQNPDKSG KTTSESSLDN
     SLNSSANQGT KSTESTHAFS DKNMIGKKEQ LPKKVLPKAG AEVPSTFWVV LGGAFLVTSG
     TIYIRKTRK
//