ID Q83GE7_TROWT Unreviewed; 364 AA.
AC Q83GE7;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Mannose-1-phosphate guanylyltransferase {ECO:0000313|EMBL:AAO44453.1};
DE EC=2.7.7.22 {ECO:0000313|EMBL:AAO44453.1};
GN Name=manC {ECO:0000313|EMBL:AAO44453.1};
GN OrderedLocusNames=TWT_356 {ECO:0000313|EMBL:AAO44453.1};
OS Tropheryma whipplei (strain Twist) (Whipple's bacillus).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Tropherymataceae;
OC Tropheryma.
OX NCBI_TaxID=203267 {ECO:0000313|EMBL:AAO44453.1, ECO:0000313|Proteomes:UP000002200};
RN [1] {ECO:0000313|EMBL:AAO44453.1, ECO:0000313|Proteomes:UP000002200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Twist {ECO:0000313|EMBL:AAO44453.1,
RC ECO:0000313|Proteomes:UP000002200};
RX PubMed=12902375; DOI=10.1101/gr.1474603;
RA Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M.,
RA Claverie J.-M.;
RT "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a
RT reduced genome.";
RL Genome Res. 13:1800-1809(2003).
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DR EMBL; AE014184; AAO44453.1; -; Genomic_DNA.
DR RefSeq; WP_011096364.1; NC_004572.3.
DR AlphaFoldDB; Q83GE7; -.
DR STRING; 203267.TWT_356; -.
DR GeneID; 67388191; -.
DR KEGG; twh:TWT_356; -.
DR eggNOG; COG0836; Bacteria.
DR HOGENOM; CLU_035527_0_1_11; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000002200; Chromosome.
DR GO; GO:0008928; F:mannose-1-phosphate guanylyltransferase (GDP) activity; IEA:UniProtKB-EC.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005976; P:polysaccharide metabolic process; IEA:InterPro.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF159283; Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000313|EMBL:AAO44453.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002200};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAO44453.1}.
FT DOMAIN 9..287
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 323..362
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 364 AA; 39204 MW; 98456387C03EB781 CRC64;
MDCSELYSVI PAGGIGSRLW PLSRAASPKF LHKLTGTETS LLRDTWDRLV PISGVDRIMV
VIGSDHFDAV TSQLPELKGH NVILEPEPKD STAAICLAAA ILNTREPDVI IGSFPADHVI
KTSPLFQQSV AQAVVAANEG YVVTIAITPT EPATQFGYIL CGDSAGIKGA PQVLSVKRFV
EKPSQKDADR YLSSGKYLWN AGMFIAKACV LLEQLEKARP DIHSLIIDIA NSPDLDSALK
KNWPKMPRIA IEYSVAEPCA AEGRMVTVPA KFEWNDAGDF SSIARLNSRG GSDLVILGET
SRVLSDSATG IVVSQTDRII SVIGTKDIVV VDTPDSLLVT TKDDAKKVKQ IVEALRLSGR
DDVL
//
