ID PHOP_SHIFL Reviewed; 223 AA.
AC Q83RR0; Q7C202;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=Virulence transcriptional regulatory protein PhoP;
GN Name=phoP; OrderedLocusNames=SF1149, S1232;
OS Shigella flexneri.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
RN [3]
RP FUNCTION.
RC STRAIN=M90T / Serotype 5a;
RX PubMed=11207599; DOI=10.1046/j.1462-5822.2000.00065.x;
RA Moss J.E., Fisher P.E., Vick B., Groisman E.A., Zychlinsky A.;
RT "The regulatory protein PhoP controls susceptibility to the host
RT inflammatory response in Shigella flexneri.";
RL Cell. Microbiol. 2:443-452(2000).
CC -!- FUNCTION: Member of the two-component regulatory system PhoQ/PhoP
CC involved in virulence and adaptation to low Mg(2+) environments.
CC Necessary for resistance to killing by polymorphonuclear leukocytes
CC (PMNs) and cationic antimicrobial peptides (CAMP) they produce.
CC {ECO:0000269|PubMed:11207599}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by PhoQ. {ECO:0000305}.
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DR EMBL; AE005674; AAN42766.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16655.1; -; Genomic_DNA.
DR RefSeq; NP_707059.1; NC_004337.2.
DR RefSeq; WP_001265481.1; NZ_WPGW01000001.1.
DR AlphaFoldDB; Q83RR0; -.
DR SMR; Q83RR0; -.
DR STRING; 198214.SF1149; -.
DR PaxDb; 198214-SF1149; -.
DR GeneID; 1024087; -.
DR GeneID; 75203716; -.
DR KEGG; sfl:SF1149; -.
DR KEGG; sfx:S1232; -.
DR PATRIC; fig|198214.7.peg.1350; -.
DR HOGENOM; CLU_000445_30_1_6; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19934; REC_OmpR_EcPhoP-like; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.690; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; REGULATOR OF RPOS; 1.
DR PANTHER; PTHR48111:SF71; TRANSCRIPTIONAL REGULATORY PROTEIN PHOP; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Repressor; Transcription; Transcription regulation;
KW Two-component regulatory system; Virulence.
FT CHAIN 1..223
FT /note="Virulence transcriptional regulatory protein PhoP"
FT /id="PRO_0000081202"
FT DOMAIN 2..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 124..222
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 51
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 223 AA; 25535 MW; 8BFF22E04F8846EC CRC64;
MRVLVVEDNA LLRHHLKVQI QDAGHQVDDA EDAKEADYYL NEHLPDIAIV DLGLPDEDGL
SLIRRWRSND VSLPILVLTA RESWQDKVEV LSAGADDYVT KPFHIEEVMA RMQALMRRNS
GLASQVISLP PFQVDLSRRE LSINDEVIKL TAFEYTIMET LIRNNGKVVS KDSLMLQLYP
DAELRESHTI DVLMGRLRKK IQAQYPQEVI TTVRGQGYLF ELR
//
