ID ENTS_SHIFL Reviewed; 410 AA.
AC Q83SB6; Q7C2S5;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=Enterobactin exporter EntS {ECO:0000255|HAMAP-Rule:MF_01436};
GN Name=entS {ECO:0000255|HAMAP-Rule:MF_01436};
GN OrderedLocusNames=SF0505, S0511;
OS Shigella flexneri.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Component of an export pathway for enterobactin.
CC {ECO:0000255|HAMAP-Rule:MF_01436}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01436}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01436}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EntS (TC
CC 2.A.1.38) family. {ECO:0000255|HAMAP-Rule:MF_01436}.
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DR EMBL; AE005674; AAN42154.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16026.1; -; Genomic_DNA.
DR RefSeq; NP_706447.1; NC_004337.2.
DR RefSeq; WP_001041804.1; NZ_WPGW01000083.1.
DR AlphaFoldDB; Q83SB6; -.
DR SMR; Q83SB6; -.
DR STRING; 198214.SF0505; -.
DR PaxDb; 198214-SF0505; -.
DR GeneID; 1023447; -.
DR KEGG; sfl:SF0505; -.
DR KEGG; sfx:S0511; -.
DR PATRIC; fig|198214.7.peg.587; -.
DR HOGENOM; CLU_034180_11_0_6; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042931; F:enterobactin transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR HAMAP; MF_01436; MFS_EntS; 1.
DR InterPro; IPR023722; Enterobactin_exp_EntS.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23513:SF9; ENTEROBACTIN EXPORTER ENTS; 1.
DR PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..410
FT /note="Enterobactin exporter EntS"
FT /id="PRO_0000227657"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 43..55
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 77..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 105..109
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 131..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 178
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 200..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 219..233
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 234..250
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 272..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 282..301
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 302..307
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 331..350
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 372
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 394..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
SQ SEQUENCE 410 AA; 42752 MW; ACE40A89E9A607E5 CRC64;
MNKQSWLLNL SLLKTHPAFR AVFLARFISI VSLGLLGVAV PVQIQMMTHS TWQVGLSVTL
TGGAMFVGLM VGGVLADRYE RKKVILLARG TCGIGFIGLC LNALLPEPSL LAIYLLGLWD
GFFASLGVTA LLAATSALVG RENLMQAGAI TMLTVRLGSV ISPMIGGLLL ATGGVAWNYG
LAAAGTFITL LPLLSLPELP PPPQPLEHPL KSLLAGFRFL LASPLLGGLL TMASAVLVLY
PALADNWQMS AAQIGFLYAA IPLGAAIGAL TSGKLAHSAR PGLLMLLSTL GSFLAIGLFG
LMPMWILGVV CLALFGWLSA VSSLLQYTML QTQTPEAMLG RINGLWTAQN VTGDAIGAAL
LGGLGAMMTP VASASASGFG LLIIGVLLLL VLVELRRFRQ TPPQVTASDS
//
