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Database: UniProt
Entry: Q84365_MUMIP
LinkDB: Q84365_MUMIP
Original site: Q84365_MUMIP 
ID   Q84365_MUMIP            Unreviewed;       721 AA.
AC   Q84365;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   07-OCT-2020, entry version 81.
DE   RecName: Full=Initiator protein NS1 {ECO:0000256|ARBA:ARBA00020731};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE   AltName: Full=NCVP1 {ECO:0000256|ARBA:ARBA00021532};
DE   AltName: Full=Non-capsid protein NS-1 {ECO:0000256|ARBA:ARBA00015091};
DE   AltName: Full=Non-structural protein NS1 {ECO:0000256|ARBA:ARBA00014071};
GN   Name=NS1 {ECO:0000313|EMBL:AAA67108.1};
OS   Murine minute virus (strain MVM prototype) (MVM) (Murine minute virus
OS   (strain MVM(p))).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes;
OC   Piccovirales; Parvoviridae; Parvovirinae; Protoparvovirus.
OX   NCBI_TaxID=648235 {ECO:0000313|Proteomes:UP000007019};
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1] {ECO:0000313|EMBL:AAA67108.1, ECO:0000313|Proteomes:UP000007019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MVM prototype {ECO:0000313|Proteomes:UP000007019};
RX   PubMed=6298737; DOI=10.1093/nar/11.4.999;
RA   Astell C.R., Thomson M., Merchlinsky M., Ward D.C.;
RT   "The complete DNA sequence of minute virus of mice, an autonomous
RT   parvovirus.";
RL   Nucleic Acids Res. 11:999-1018(1983).
RN   [2] {ECO:0000313|EMBL:AAA67108.1, ECO:0000313|Proteomes:UP000007019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MVM prototype {ECO:0000313|Proteomes:UP000007019};
RX   PubMed=3502703;
RA   Astell C.R., Gardiner E.M., Tattersall P.;
RT   "DNA sequence of the lymphotropic variant of minute virus of mice, MVM(i),
RT   and comparison with the DNA sequence of the fibrotropic prototype strain.";
RL   J. Virol. 57:656-669(1986).
RN   [3] {ECO:0000313|EMBL:AAA67108.1, ECO:0000313|Proteomes:UP000007019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MVM prototype {ECO:0000313|Proteomes:UP000007019};
RX   PubMed=3783817;
RA   Morgan W.R., Ward D.C.;
RT   "Three splicing patterns are used to excise the small intron common to all
RT   minute virus of mice RNAs.";
RL   J. Virol. 60:1170-1174(1986).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the parvoviruses initiator protein NS1 family.
CC       {ECO:0000256|ARBA:ARBA00009826}.
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DR   EMBL; J02275; AAA67108.1; -; Genomic_DNA.
DR   RefSeq; NP_041242.1; NC_001510.1.
DR   GeneID; 1489590; -.
DR   KEGG; vg:1489590; -.
DR   Proteomes; UP000007019; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039645; P:modulation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021972; Parvovirus_NS1_C.
DR   InterPro; IPR001257; Parvovirus_NS1_helicase.
DR   InterPro; IPR021076; Parvovirus_NS1_N.
DR   Pfam; PF12117; DUF3580; 1.
DR   Pfam; PF01057; Parvo_NS1; 1.
DR   Pfam; PF12433; PV_NSP1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51206; SF3_HELICASE_1; 1.
PE   3: Inferred from homology;
KW   Covalent protein-DNA linkage {ECO:0000256|ARBA:ARBA00023124};
KW   DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   G1/S host cell cycle checkpoint dysregulation by virus
KW   {ECO:0000256|ARBA:ARBA00023309};
KW   Host G2/M cell cycle arrest by virus {ECO:0000256|ARBA:ARBA00022565};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023309};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW   Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007019};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Viral DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW   Viral genome packaging {ECO:0000256|ARBA:ARBA00023219};
KW   Viral release from host cell {ECO:0000256|ARBA:ARBA00022612}.
FT   DOMAIN          422..577
FT                   /note="SF3 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51206"
FT   REGION          662..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..692
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  81896 MW;  18391758E42F0DCF CRC64;
     MISGSGSLNQ GAKRKWAWFK VYKQLLKSVT YLFFHSVSRD AQKESNQLTM AGNAYSDEVL
     GATNWLKEKS NQEVFSFVFK NENVQLNGKD IGWNSYKKEL QEDELKSLQR GAETTWDQSE
     DMEWETTVDE MTKKQVFIFD SLVKKCLFEV LNTKNIFPGD VNWFVQHEWG KDQGWHCHVL
     IGGKDFSQAQ GKWWRRQLNV YWSRWLVTAC NVQLTPAERI KLREIAEDNE WVTLLTYKHK
     QTKKDYTKCV LFGNMIAYYF LTKKKISTSP PRDGGYFLSS DSGWKTNFLK EGERHLVSKL
     YTDDMRPETV ETTVTTAQET KRGRIQTKKE VSIKTTLKEL VHKRVTSPED WMMMQPDSYI
     EMMAQPGGEN LLKNTLEICT LTLARTKTAF DLILEKAETS KLTNFSLPDT RTCRIFAFHG
     WNYVKVCHAI CCVLNRQGGK RNTVLFHGPA STGKSIIAQA IAQAVGNVGC YNAANVNFPF
     NDCTNKNLIW VEEAGNFGQQ VNQFKAICSG QTIRIDQKGK GSKQIEPTPV IMTTNENITV
     VRIGCEERPE HTQPIRDRML NIHLTHTLPG DFGLVDKNEW PMICAWLVKN GYQSTMASYC
     AKWGKVPDWS ENWAEPKVPT PINLLGSARS PFTTPKSTPL SQNYALTPLA SDLEDLALEP
     WSTPNTPVAG TAETQNTGEA GSKACQDGQL SPTWSEIEED LRACFGAEPL KKDFSEPLNL
     D
//
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