GenomeNet

Database: UniProt
Entry: Q863C4
LinkDB: Q863C4
Original site: Q863C4 
ID   ITB6_SHEEP              Reviewed;         787 AA.
AC   Q863C4;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   10-APR-2019, entry version 92.
DE   RecName: Full=Integrin beta-6;
DE   Flags: Precursor;
GN   Name=ITGB6;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Airway epithelium;
RA   McAleese S.M., Collie D.D.S., Miller H.R.P.;
RT   "Cloning and sequencing of the cDNA for sheep integrin subunit beta-
RT   6.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for
CC       fibronectin and cytotactin (By similarity). It recognizes the
CC       sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as
CC       a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent
CC       cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6
CC       (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming
CC       growth factor beta-1 (TGF-beta-1) from regulatory Latency-
CC       associated peptide (LAP), thereby playing a key role in TGF-beta-1
CC       activation (By similarity). {ECO:0000250|UniProtKB:P18564,
CC       ECO:0000250|UniProtKB:Q9Z0T9}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit (By
CC       similarity). Interacts with FLNB. Interacts with HAX1. ITGAV:ITGB6
CC       interacts with FBN1 (By similarity). ITGAV:ITGB6 interacts with
CC       TGFB1 (By similarity). {ECO:0000250|UniProtKB:P18564,
CC       ECO:0000250|UniProtKB:Q9Z0T9}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Cell junction, focal adhesion
CC       {ECO:0000250|UniProtKB:P18564}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000305}.
DR   EMBL; AJ439062; CAD27749.1; -; mRNA.
DR   RefSeq; XP_011966335.1; XM_012110945.2.
DR   UniGene; Oar.1024; -.
DR   ProteinModelPortal; Q863C4; -.
DR   SMR; Q863C4; -.
DR   STRING; 9940.ENSOARP00000007475; -.
DR   PRIDE; Q863C4; -.
DR   Ensembl; ENSOART00000007587; ENSOARP00000007475; ENSOARG00000006967.
DR   GeneID; 443209; -.
DR   CTD; 3694; -.
DR   GeneTree; ENSGT00950000182617; -.
DR   HOVERGEN; HBG006190; -.
DR   OMA; VSIPNCE; -.
DR   OrthoDB; 473040at2759; -.
DR   Proteomes; UP000002356; Chromosome 2.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; ISS:UniProtKB.
DR   GO; GO:0034685; C:integrin alphav-beta6 complex; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0033627; P:cell adhesion mediated by integrin; ISS:UniProtKB.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:1901388; P:regulation of transforming growth factor beta activation; ISS:UniProtKB.
DR   GO; GO:0038044; P:transforming growth factor-beta secretion; IEA:Ensembl.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR040622; I-EGF_1.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR015436; Integrin_bsu-6.
DR   InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR   InterPro; IPR012896; Integrin_bsu_tail.
DR   InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF11; PTHR10082:SF11; 1.
DR   Pfam; PF18372; I-EGF_1; 1.
DR   Pfam; PF08725; Integrin_b_cyt; 1.
DR   Pfam; PF07965; Integrin_B_tail; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   Pfam; PF17205; PSI_integrin; 1.
DR   PIRSF; PIRSF002512; Integrin_B; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM01241; Integrin_b_cyt; 1.
DR   SMART; SM01242; Integrin_B_tail; 1.
DR   SMART; SM00423; PSI; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF69179; SSF69179; 2.
DR   SUPFAM; SSF69687; SSF69687; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS00243; INTEGRIN_BETA; 2.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Complete proteome; Disulfide bond;
KW   Glycoprotein; Host cell receptor for virus entry;
KW   Host-virus interaction; Integrin; Membrane; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    787       Integrin beta-6.
FT                                /FTId=PRO_0000273713.
FT   TOPO_DOM     22    708       Extracellular. {ECO:0000255}.
FT   TRANSMEM    709    729       Helical. {ECO:0000255}.
FT   TOPO_DOM    730    787       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      131    371       VWFA.
FT   REPEAT      456    501       I.
FT   REPEAT      502    543       II.
FT   REPEAT      544    582       III.
FT   REPEAT      583    619       IV.
FT   REGION      456    619       Cysteine-rich tandem repeat.
FT   REGION      730    757       Interaction with HAX1. {ECO:0000250}.
FT   CARBOHYD     48     48       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     97     97       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    260    260       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    387    387       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    418    418       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    463    463       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    471    471       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    541    541       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    575    575       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     23    454       {ECO:0000250}.
FT   DISULFID     31     41       {ECO:0000250}.
FT   DISULFID     34     70       {ECO:0000250}.
FT   DISULFID     44     59       {ECO:0000250}.
FT   DISULFID    197    204       {ECO:0000250|UniProtKB:P18564}.
FT   DISULFID    252    293       {ECO:0000250|UniProtKB:P18564}.
FT   DISULFID    394    406       {ECO:0000250}.
FT   DISULFID    426    670       {ECO:0000250}.
FT   DISULFID    452    456       {ECO:0000250}.
FT   DISULFID    467    479       {ECO:0000250}.
FT   DISULFID    476    511       {ECO:0000250}.
FT   DISULFID    481    490       {ECO:0000250}.
FT   DISULFID    492    502       {ECO:0000250}.
FT   DISULFID    517    522       {ECO:0000250}.
FT   DISULFID    519    552       {ECO:0000250}.
FT   DISULFID    524    537       {ECO:0000250}.
FT   DISULFID    539    544       {ECO:0000250}.
FT   DISULFID    558    563       {ECO:0000250}.
FT   DISULFID    560    591       {ECO:0000250}.
FT   DISULFID    565    574       {ECO:0000250}.
FT   DISULFID    576    583       {ECO:0000250}.
FT   DISULFID    597    602       {ECO:0000250}.
FT   DISULFID    599    645       {ECO:0000250}.
FT   DISULFID    604    614       {ECO:0000250}.
FT   DISULFID    617    620       {ECO:0000250}.
FT   DISULFID    624    633       {ECO:0000250}.
FT   DISULFID    630    701       {ECO:0000250}.
FT   DISULFID    649    678       {ECO:0000250}.
SQ   SEQUENCE   787 AA;  85746 MW;  B7AC4903A9C7A89E CRC64;
     MGIELLCLFF LFLGRNDHVQ GGCAMGGAET CEDCLLIGPQ CAWCSQENFT HLSGVGERCD
     TPANLLAKGC QLTFIENPVS QVEILTNKPL SIGRQKNSSN IVQISPQSLA LKLRPGLEQT
     LQVQVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSLLS KEMSKLTSNF RLGFGSFVEK
     PISPFMKTTP EEIANPCSSI PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE
     GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE
     YSMSTILEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GVLQKDSGNI
     LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNSGVPF PHQKKCSHMK VGDTASFNVT
     VSLPNCERRS RHVILKPVGL GDALEILVSP ECSCDCQKEV EVNSSKCSNG NGSFQCGVCA
     CNPGHVGHHC ECGEDTLSTE SCKEAPELPS CSGRGDCYCG QCVCHLSPYG NIYGPYCQCD
     NFSCVRHKGL LCGDNGDCDC GECVCRSGWT GEYCNCTTST DPCVSEDGIL CSGRGDCVCG
     KCICTNPGAS GPACERCPTC SDPCNSKRNC IECYLSADGQ AQEECVDKCK LAGATINEEE
     DFSKDSSVSC SLQGENECLI TFLLTTDNEG KTVIHSIEKD CPKPPNIPMI MLGVSLAILL
     IGVALLCIWK LLVSFHDRKE VAKFEAERSK AKWQTGTNPL YRGSTSTFKN VTYKHKEKQK
     VDLSTDG
//
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