GenomeNet

Database: UniProt
Entry: Q869Z1_DICDI
LinkDB: Q869Z1_DICDI
Original site: Q869Z1_DICDI 
ID   Q869Z1_DICDI            Unreviewed;      1472 AA.
AC   Q869Z1; Q553V0;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   24-JAN-2024, entry version 145.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=dhx9 {ECO:0000313|EMBL:EAL69937.1};
GN   ORFNames=DDB_G0275313 {ECO:0000313|EMBL:EAL69937.1};
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL69937.1, ECO:0000313|Proteomes:UP000002195};
RN   [1] {ECO:0000313|EMBL:EAL69937.1, ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|EMBL:EAL69937.1,
RC   ECO:0000313|Proteomes:UP000002195};
RX   PubMed=12097910; DOI=10.1038/nature00847;
RG   Dictyostelium Genome Sequencing Consortium;
RA   Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2] {ECO:0000313|EMBL:EAL69937.1, ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|EMBL:EAL69937.1,
RC   ECO:0000313|Proteomes:UP000002195};
RX   PubMed=15875012; DOI=10.1038/nature03481;
RG   The Dictyostelium discoideum Sequencing Consortium;
RA   Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA   White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA   Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA   Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA   Noegel A.A., Barrell B., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000256|ARBA:ARBA00008792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL69937.1}.
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DR   EMBL; AAFI02000013; EAL69937.1; -; Genomic_DNA.
DR   RefSeq; XP_643861.1; XM_638769.1.
DR   AlphaFoldDB; Q869Z1; -.
DR   SMR; Q869Z1; -.
DR   STRING; 44689.Q869Z1; -.
DR   PaxDb; 44689-DDB0233740; -.
DR   GeneID; 8619912; -.
DR   KEGG; ddi:DDB_G0275313; -.
DR   dictyBase; DDB_G0275313; dhx9.
DR   eggNOG; KOG0920; Eukaryota.
DR   HOGENOM; CLU_250156_0_0_1; -.
DR   InParanoid; Q869Z1; -.
DR   OMA; HERDIHT; -.
DR   PhylomeDB; Q869Z1; -.
DR   Reactome; R-DDI-3134963; DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; ISS:dictyBase.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   CDD; cd17917; DEXHc_RHA-like; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA/RNA HELICASE DHX36; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00035; dsrm; 2.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00358; DSRM; 2.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:EAL69937.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          364..441
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          727..895
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          932..1110
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          449..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1199..1218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1472 AA;  167047 MW;  C532AD1C5CAA8BA1 CRC64;
     MSYNNSYNNS YNSNNNNNNS YNSNNNNNNN NNNNNNNNNN NNSNNNNNNY NNNFSSGGRS
     NYNNYNNYNS YNNDFNNSNN NYRGNSVFGN KNNSYLNKGG NKVYNTSNSN INYNNNNNNN
     NNNNNNNNNS NNNNNNNNQG QTSYNNNNNN SNNNNNNNNQ GQTSYNNNNN INNNIINSGL
     NSLNNNNNNN NNNNYSGLEN NINNYQQTPP ILQQQQPLLS NPINHFEQPA PVYAGDPFQL
     LHHNDSNKLN DEYLSSYDRL GQSSYNGGMG GYNNNNNNNN NNNINNNNNN NNNNNNNNNN
     QNYGGYNRQT IPPVESPSFR YTSNVGGNLN SNFNISSSSS GGSGGSGGSG GSGSGSNNIF
     TIENSKGFLN QYMIKLGKRP NDQYISSTSH GLPPNQTFET ILELPFPTHL GRDSMKITGK
     GSSKNESKTQ CAEKACRVLA EMGLINSSNK GSSTTNFPSD MASGGGSGGG GGELQMETVP
     DSQFDESKKL VQQKGIRSSC LEFENSCLLS HSNGGINGIL GPSGISWKFD AAKRKIEQYC
     KQFGYPENNV YRSHETSRGS LMKFSKTFVV EMYLPIQGVV QKITITESDN KKLSENLAAV
     DACEYLLENE LIQPEYKAPK SSTLSDEFFK INYDIPPEIY QQSRETLESV TYQNNEFYPR
     KILQLNKKIN TYTPQQTLLD VKSFEELSDI GIERRAYEHN KRQTAEYKRI YQKRTELPIF
     KQRSHLIESI KNNQIIIIMG DTGCGKTTQI PQFVIEDMID SGHAPYCNIV MTQPRRISVL
     GAAERMAYER LEKVGDTVGY QIRFDNVQPL GTSKLLVCTP GILLKRMYSD MKLHNVSHLF
     IDEVHERDIH TDFLLIILKK LLADNNNLRV ILMSATMDNS LVSAYFGTCP VIKLTSYHHI
     AQEYFLEDIS KQLNDPTISY RDEQSDDVDH EMILQLIVHI VTKVSSTSED SILIFLPGWE
     DISQTRELMR RHPMLRNENE FLILPLHSSV SMQLQAKVFE KPPPKIRKIV LSTNIAETSI
     TINDVVYVID SAKVKLKYHE TQRDLTLFQT VWACKSSLKQ RRGRAGRVRK DGVCYHMVSR
     DRYNTLEEFQ LSEMRRMPLH ELCLQVKVLV LGDVIGFLSE ALEPPETKSI DNAINLLIDL
     GALNANQELT PLGLQLSFIP VDPRIGKMII LGSYFRCLDP ILTIASFSNQ KNPITTLYNQ
     GNDNNNNNNN NNNNSYYNNY YQQQPQQPKN LYPELQSDHL SFLNIFNGWL QSRMDGTEDQ
     YCQDFLSIPL LQQILKVKKQ LLSTINDLGI INAQLRDGFV NNSFFNENSN NLDIIRAIIC
     SGLFPNIARQ RKKREFKTLS ENTFLHPSSI VYNLFQELNP KENWVIFEEK FKTKLTFIKT
     ITRIPEISLL LFGSTPIFNQ TSTENSTVSI NGTQIKFYIP TLSCHLLLSI REQMEKSLQK
     YIEQSDYSNS FSKTDYEFQK CLMALLSFNF NK
//
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