ID Q869Z1_DICDI Unreviewed; 1472 AA.
AC Q869Z1; Q553V0;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 24-JAN-2024, entry version 145.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=dhx9 {ECO:0000313|EMBL:EAL69937.1};
GN ORFNames=DDB_G0275313 {ECO:0000313|EMBL:EAL69937.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL69937.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL69937.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL69937.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL69937.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL69937.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL69937.1}.
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DR EMBL; AAFI02000013; EAL69937.1; -; Genomic_DNA.
DR RefSeq; XP_643861.1; XM_638769.1.
DR AlphaFoldDB; Q869Z1; -.
DR SMR; Q869Z1; -.
DR STRING; 44689.Q869Z1; -.
DR PaxDb; 44689-DDB0233740; -.
DR GeneID; 8619912; -.
DR KEGG; ddi:DDB_G0275313; -.
DR dictyBase; DDB_G0275313; dhx9.
DR eggNOG; KOG0920; Eukaryota.
DR HOGENOM; CLU_250156_0_0_1; -.
DR InParanoid; Q869Z1; -.
DR OMA; HERDIHT; -.
DR PhylomeDB; Q869Z1; -.
DR Reactome; R-DDI-3134963; DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA/RNA HELICASE DHX36; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EAL69937.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 364..441
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 727..895
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 932..1110
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1472 AA; 167047 MW; C532AD1C5CAA8BA1 CRC64;
MSYNNSYNNS YNSNNNNNNS YNSNNNNNNN NNNNNNNNNN NNSNNNNNNY NNNFSSGGRS
NYNNYNNYNS YNNDFNNSNN NYRGNSVFGN KNNSYLNKGG NKVYNTSNSN INYNNNNNNN
NNNNNNNNNS NNNNNNNNQG QTSYNNNNNN SNNNNNNNNQ GQTSYNNNNN INNNIINSGL
NSLNNNNNNN NNNNYSGLEN NINNYQQTPP ILQQQQPLLS NPINHFEQPA PVYAGDPFQL
LHHNDSNKLN DEYLSSYDRL GQSSYNGGMG GYNNNNNNNN NNNINNNNNN NNNNNNNNNN
QNYGGYNRQT IPPVESPSFR YTSNVGGNLN SNFNISSSSS GGSGGSGGSG GSGSGSNNIF
TIENSKGFLN QYMIKLGKRP NDQYISSTSH GLPPNQTFET ILELPFPTHL GRDSMKITGK
GSSKNESKTQ CAEKACRVLA EMGLINSSNK GSSTTNFPSD MASGGGSGGG GGELQMETVP
DSQFDESKKL VQQKGIRSSC LEFENSCLLS HSNGGINGIL GPSGISWKFD AAKRKIEQYC
KQFGYPENNV YRSHETSRGS LMKFSKTFVV EMYLPIQGVV QKITITESDN KKLSENLAAV
DACEYLLENE LIQPEYKAPK SSTLSDEFFK INYDIPPEIY QQSRETLESV TYQNNEFYPR
KILQLNKKIN TYTPQQTLLD VKSFEELSDI GIERRAYEHN KRQTAEYKRI YQKRTELPIF
KQRSHLIESI KNNQIIIIMG DTGCGKTTQI PQFVIEDMID SGHAPYCNIV MTQPRRISVL
GAAERMAYER LEKVGDTVGY QIRFDNVQPL GTSKLLVCTP GILLKRMYSD MKLHNVSHLF
IDEVHERDIH TDFLLIILKK LLADNNNLRV ILMSATMDNS LVSAYFGTCP VIKLTSYHHI
AQEYFLEDIS KQLNDPTISY RDEQSDDVDH EMILQLIVHI VTKVSSTSED SILIFLPGWE
DISQTRELMR RHPMLRNENE FLILPLHSSV SMQLQAKVFE KPPPKIRKIV LSTNIAETSI
TINDVVYVID SAKVKLKYHE TQRDLTLFQT VWACKSSLKQ RRGRAGRVRK DGVCYHMVSR
DRYNTLEEFQ LSEMRRMPLH ELCLQVKVLV LGDVIGFLSE ALEPPETKSI DNAINLLIDL
GALNANQELT PLGLQLSFIP VDPRIGKMII LGSYFRCLDP ILTIASFSNQ KNPITTLYNQ
GNDNNNNNNN NNNNSYYNNY YQQQPQQPKN LYPELQSDHL SFLNIFNGWL QSRMDGTEDQ
YCQDFLSIPL LQQILKVKKQ LLSTINDLGI INAQLRDGFV NNSFFNENSN NLDIIRAIIC
SGLFPNIARQ RKKREFKTLS ENTFLHPSSI VYNLFQELNP KENWVIFEEK FKTKLTFIKT
ITRIPEISLL LFGSTPIFNQ TSTENSTVSI NGTQIKFYIP TLSCHLLLSI REQMEKSLQK
YIEQSDYSNS FSKTDYEFQK CLMALLSFNF NK
//