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Database: UniProt
Entry: Q86AG5_DICDI
LinkDB: Q86AG5_DICDI
Original site: Q86AG5_DICDI 
ID   Q86AG5_DICDI            Unreviewed;       608 AA.
AC   Q86AG5; Q55A78;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-MAY-2019, entry version 92.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAL71448.1};
GN   ORFNames=DDB0168626 {ECO:0000313|EMBL:EAL71448.1};
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL71448.1, ECO:0000313|Proteomes:UP000002195};
RN   [1] {ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|Proteomes:UP000002195};
RX   PubMed=12097910; DOI=10.1038/nature00847;
RG   Dictyostelium Genome Sequencing Consortium;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A.,
RA   Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G.,
RA   Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A.,
RA   Platzer M., Rosenthal A., Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2] {ECO:0000313|EMBL:EAL71448.1, ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|EMBL:EAL71448.1,
RC   ECO:0000313|Proteomes:UP000002195};
RX   PubMed=15875012; DOI=10.1038/nature03481;
RG   The Dictyostelium discoideum Sequencing Consortium;
RA   Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K.,
RA   Chen G., Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X.,
RA   Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B.,
RA   Just E., Morio T., Rost R., Churcher C., Cooper J., Haydock S.,
RA   van Driessche N., Cronin A., Goodhead I., Muzny D., Mourier T.,
RA   Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K., Quiles M.,
RA   Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M.,
RA   Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.,
RA   Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J.,
RA   Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S.,
RA   Simmonds M., Spiegler S., Tivey A., Sugano S., White B., Walker D.,
RA   Woodward J., Winckler T., Tanaka Y., Shaulsky G., Schleicher M.,
RA   Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.,
RA   Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA   Noegel A.A., Barrell B., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAL71448.1}.
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DR   EMBL; AAFI01000018; EAL71448.1; -; Genomic_DNA.
DR   RefSeq; XP_645388.1; XM_640296.1.
DR   STRING; 44689.DDB0168626; -.
DR   MEROPS; S53.A01; -.
DR   PaxDb; Q86AG5; -.
DR   GeneID; 8618277; -.
DR   KEGG; ddi:DDB_G0272028; -.
DR   eggNOG; ENOG410JEC4; Eukaryota.
DR   eggNOG; ENOG410XR23; LUCA.
DR   InParanoid; Q86AG5; -.
DR   PhylomeDB; Q86AG5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008240; F:tripeptidyl-peptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 2.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002195};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   DOMAIN      120    608       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    192    192       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    196    196       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    532    532       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       577    577       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       578    578       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       600    600       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       602    602       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   608 AA;  66425 MW;  4AA7A6A2C25F1606 CRC64;
     MSLEEINLLV SPSNEDVKTV VNWLKSNDIG KEEMMVHSDF IQLRINVMKA SNLFETEFAY
     YQSIRNSLDQ RIRIVESASI PKYLKNKIDF ILGLSDFIED NKFYETMFKS RIDVKDSFVT
     ITPSFIKSYY GIPFNQVGEN ENNSISVASF NDFYSAGALG YFDSEYNIDS SSIRVNNSGP
     NCFGLNYCGQ AESDLDIQYI TAIGNNISTL FLSSGNGEWV LDWASSIQLF NPIPKIASIS
     YSWAELEQCQ ATSFCPTLGI DSQIYIQRSN IEFQKIGLRG TTIFVSSGDD GSTSFYSTSG
     NCPIDGLNHY CPLGGCNHTI TQCPSITIIQ SNGSLAIFPN GIGANTGILF SNQSFVDAVN
     EFIKTNWQCD LSIEEDFSQN PHLYSSCSCE NLIPTSNDEL GIKIIGYSFD ENAGSLFSPQ
     YPTSSPYVTS VGATQIITNQ PDEIVCSSST GAAVTSGGGF AVTQSQPYYQ VVAVAKYLET
     AENLPPSFSF DPTKRAYPDI SLVAHKYSIG YSANDSSLDS CPCGLINVDG TSASTPTVAG
     IFALINDKLL SAGKSQLGFL NPLLYQAAQE QPNVFNDIVT GNINCNRAYC CQYGFSAAVG
     YDPATDLF
//
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