ID Q86PR3_AEDAE Unreviewed; 110 AA.
AC Q86PR3;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Sterol carrier protein 2 {ECO:0000313|EMBL:AAO34708.1, ECO:0000313|EMBL:AAQ08007.1};
GN Name=SCP-2 {ECO:0000313|EMBL:AAQ08007.1};
GN Synonyms=110681488 {ECO:0000313|EnsemblMetazoa:AAEL026044-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:AAO34708.1};
RN [1] {ECO:0000313|EMBL:AAQ08007.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Rockefeller {ECO:0000313|EMBL:AAQ08007.1};
RA Krebs K.C., Lan Q.;
RT "Isolation and expression of a sterol carrier protein-2 cDNA from the
RT yellow fever mosquito, Aedes aegypti.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAO34708.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Rockefeller {ECO:0000313|EMBL:AAO34708.1};
RA Krebs K.C., Brzoza K.L., Lan Q.;
RT "Use of Subtracted Libraries and Macroarray to Isolate Developmentally
RT Specific Genes from the Mosquito, Aedes aegypti.";
RL Insect Biochem. Mol. Biol. 0:0-0(2003).
RN [3] {ECO:0000313|EMBL:AAO34708.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Rockefeller {ECO:0000313|EMBL:AAO34708.1};
RX PubMed=12542635; DOI=10.1046/j.1365-2583.2003.00386.x;
RA Krebs K.C., Lan Q.;
RT "Isolation and expression of a sterol carrier protein-2 gene from the
RT yellow fever mosquito, Aedes aegypti.";
RL Insect Mol. Biol. 12:51-60(2003).
RN [4] {ECO:0007829|PDB:1PZ4}
RP X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS).
RX PubMed=12855689; DOI=10.1074/jbc.m306214200;
RA Dyer D.H., Lovell S., Thoden J.B., Holden H.M., Rayment I., Lan Q.;
RT "The structural determination of an insect sterol carrier protein-2 with a
RT ligand-bound C16 fatty acid at 1.35-A resolution.";
RL J. Biol. Chem. 278:39085-39091(2003).
RN [5] {ECO:0000313|EMBL:ACT78578.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Rockefeller {ECO:0000313|EMBL:ACT78578.1};
RA Vyazunova I., Lan Q.;
RT "Yellow fever mosquito sterol carrier protein-2 gene structure and
RT transcriptional regulation.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0007829|PDB:2KSH}
RP STRUCTURE BY NMR.
RA Singarapu N., Radek J.T., Tonelli M., Lan Q., Markley J.L.;
RT "Solution NMR structure of apo Sterol Carrier Protein - 2 from Aedes
RT aegypti (AeSCP-2).";
RL Submitted (JAN-2010) to the PDB data bank.
RN [7] {ECO:0007829|PDB:2KSI}
RP STRUCTURE BY NMR.
RA Singarapu K., Radek J.T., Tonelli M., Markley J.L., Lan Q.;
RT "Solution NMR structure of Sterol Carrier Protein - 2 from Aedes aegypti
RT (AeSCP-2) complex with C16 fatty acid (palmitate).";
RL Submitted (JAN-2010) to the PDB data bank.
RN [8] {ECO:0000313|EnsemblMetazoa:AAEL026044-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL026044-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EnsemblMetazoa:AAEL026044-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL026044-PA};
RG EnsemblMetazoa;
RL Submitted (OCT-2022) to UniProtKB.
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DR EMBL; AY190283; AAO34708.1; -; mRNA.
DR EMBL; AF510492; AAQ08007.1; -; mRNA.
DR EMBL; FJ554568; ACT78578.1; -; Genomic_DNA.
DR PDB; 1PZ4; X-ray; 1.35 A; A=1-110.
DR PDB; 2KSH; NMR; -; A=1-110.
DR PDB; 2KSI; NMR; -; A=1-110.
DR PDBsum; 1PZ4; -.
DR PDBsum; 2KSH; -.
DR PDBsum; 2KSI; -.
DR AlphaFoldDB; Q86PR3; -.
DR SMR; Q86PR3; -.
DR BindingDB; Q86PR3; -.
DR ChEMBL; CHEMBL3588733; -.
DR EnsemblMetazoa; AAEL026044-RA; AAEL026044-PA; AAEL026044.
DR VEuPathDB; VectorBase:AAEL026044; -.
DR InParanoid; Q86PR3; -.
DR OrthoDB; 2140828at2759; -.
DR BRENDA; 2.3.1.176; 149.
DR EvolutionaryTrace; Q86PR3; -.
DR Proteomes; UP000008820; Chromosome 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR039543; POX18/NSL-TP1.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR PANTHER; PTHR10094:SF25; SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR10094; STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN; 1.
DR Pfam; PF02036; SCP2; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:1PZ4, ECO:0007829|PDB:2KSH};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT DOMAIN 12..99
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 110 AA; 12272 MW; 5A79FC1CC20298CE CRC64;
MSLKSDEVFA KIAKRLESID PANRQVEHVY KFRITQGGKV VKNWVMDLKN VKLVESDDAA
EATLTMEDDI MFAIGTGALP AKEAMAQDKM EVDGQVELIF LLEPFIASLK
//
