GenomeNet

Database: UniProt
Entry: Q86T13
LinkDB: Q86T13
Original site: Q86T13 
ID   CLC14_HUMAN             Reviewed;         490 AA.
AC   Q86T13; Q695G9; Q6PWT6; Q8N5V5;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   13-FEB-2019, entry version 142.
DE   RecName: Full=C-type lectin domain family 14 member A;
DE   AltName: Full=Epidermal growth factor receptor 5;
DE            Short=EGFR-5;
DE   Flags: Precursor;
GN   Name=CLEC14A; Synonyms=C14orf27, EGFR5; ORFNames=UNQ236/PRO269;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15636369;
RA   Fu J.Q., Wang L., Chen W., Ci H.L., Li Y.P.;
RT   "Cloning and characterization of a novel human ceg1 gene cDNA.";
RL   Shi Yan Sheng Wu Xue Bao 37:409-417(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   Li W.B., Gruber C., Jessee J., Polayes D.;
RT   "Full-length cDNA libraries and normalization.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 22-36.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
DR   EMBL; AY573061; AAS77882.1; -; mRNA.
DR   EMBL; AY606132; AAT92280.1; -; mRNA.
DR   EMBL; BX248017; CAD62342.1; -; mRNA.
DR   EMBL; AY358395; AAQ88761.1; -; mRNA.
DR   EMBL; AL161751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC031567; AAH31567.2; -; mRNA.
DR   CCDS; CCDS9667.1; -.
DR   RefSeq; NP_778230.1; NM_175060.2.
DR   UniGene; Hs.525307; -.
DR   ProteinModelPortal; Q86T13; -.
DR   SMR; Q86T13; -.
DR   BioGrid; 127776; 54.
DR   IntAct; Q86T13; 12.
DR   STRING; 9606.ENSP00000353013; -.
DR   iPTMnet; Q86T13; -.
DR   PhosphoSitePlus; Q86T13; -.
DR   SwissPalm; Q86T13; -.
DR   BioMuta; CLEC14A; -.
DR   DMDM; 34582300; -.
DR   jPOST; Q86T13; -.
DR   PaxDb; Q86T13; -.
DR   PeptideAtlas; Q86T13; -.
DR   PRIDE; Q86T13; -.
DR   ProteomicsDB; 69656; -.
DR   Ensembl; ENST00000342213; ENSP00000353013; ENSG00000176435.
DR   GeneID; 161198; -.
DR   KEGG; hsa:161198; -.
DR   UCSC; uc001wum.3; human.
DR   CTD; 161198; -.
DR   DisGeNET; 161198; -.
DR   EuPathDB; HostDB:ENSG00000176435.6; -.
DR   GeneCards; CLEC14A; -.
DR   HGNC; HGNC:19832; CLEC14A.
DR   HPA; HPA039468; -.
DR   HPA; HPA048119; -.
DR   neXtProt; NX_Q86T13; -.
DR   OpenTargets; ENSG00000176435; -.
DR   PharmGKB; PA134890576; -.
DR   eggNOG; ENOG410IGD4; Eukaryota.
DR   eggNOG; ENOG41119V9; LUCA.
DR   GeneTree; ENSGT00930000151088; -.
DR   HOGENOM; HOG000111782; -.
DR   HOVERGEN; HBG051004; -.
DR   InParanoid; Q86T13; -.
DR   KO; K17528; -.
DR   OMA; CYSLHHA; -.
DR   OrthoDB; 747312at2759; -.
DR   PhylomeDB; Q86T13; -.
DR   TreeFam; TF330714; -.
DR   ChiTaRS; CLEC14A; human.
DR   GenomeRNAi; 161198; -.
DR   PRO; PR:Q86T13; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000176435; Expressed in 197 organ(s), highest expression level in right lung.
DR   Genevisible; Q86T13; HS.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0050840; F:extracellular matrix binding; IBA:GO_Central.
DR   GO; GO:1990430; F:extracellular matrix protein binding; IDA:MGI.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR   PROSITE; PS01186; EGF_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Lectin; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     21       {ECO:0000269|PubMed:15340161}.
FT   CHAIN        22    490       C-type lectin domain family 14 member A.
FT                                /FTId=PRO_0000017377.
FT   TOPO_DOM     22    397       Extracellular. {ECO:0000255}.
FT   TRANSMEM    398    418       Helical. {ECO:0000255}.
FT   TOPO_DOM    419    490       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       33    173       C-type lectin. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00040}.
FT   DOMAIN      245    287       EGF-like.
FT   CARBOHYD    189    189       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    381    381       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    143    162       {ECO:0000255|PROSITE-ProRule:PRU00040}.
FT   CONFLICT    432    432       Q -> H (in Ref. 1; AAS77882).
FT                                {ECO:0000305}.
FT   CONFLICT    437    437       S -> F (in Ref. 1; AAS77882).
FT                                {ECO:0000305}.
SQ   SEQUENCE   490 AA;  51636 MW;  CE453A274CD39BF6 CRC64;
     MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA EEACILRGGA
     LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR SHCTLENEPL RGFSWLSSDP
     GGLESDTLQW VEEPQRSCTA RRCAVLQATG GVEPAGWKEM RCHLRANGYL CKYQFEVLCP
     APRPGAASNL SYRAPFQLHS AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG
     DVLCPCPGRY LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG
     VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG SQSTMSTLQM
     SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF IFVSTAVVVL VILTMTVLGL
     VKLCFHESPS SQPRKESMGP PGLESDPEPA ALGSSSAHCT NNGVKVGDCD LRDRAEGALL
     AESPLGSSDA
//
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