ID TRI73_HUMAN Reviewed; 250 AA.
AC Q86UV7; Q8N0S3;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE RecName: Full=Tripartite motif-containing protein 73;
DE AltName: Full=Tripartite motif-containing protein 50B;
GN Name=TRIM73; Synonyms=TRIM50B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18398435; DOI=10.1038/ejhg.2008.68;
RA Micale L., Fusco C., Augello B., Napolitano L.M.R., Dermitzakis E.T.,
RA Meroni G., Merla G., Reymond A.;
RT "Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.";
RL Eur. J. Hum. Genet. 16:1038-1049(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AF498998; AAP30735.1; -; mRNA.
DR EMBL; AC006014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS34665.1; -.
DR RefSeq; NP_944606.2; NM_198924.3.
DR AlphaFoldDB; Q86UV7; -.
DR SMR; Q86UV7; -.
DR BioGRID; 131985; 20.
DR IntAct; Q86UV7; 1.
DR STRING; 9606.ENSP00000318615; -.
DR BioMuta; TRIM73; -.
DR DMDM; 56404880; -.
DR MassIVE; Q86UV7; -.
DR PaxDb; 9606-ENSP00000318615; -.
DR Antibodypedia; 56753; 54 antibodies from 13 providers.
DR DNASU; 375593; -.
DR Ensembl; ENST00000323819.8; ENSP00000318615.3; ENSG00000178809.12.
DR GeneID; 375593; -.
DR KEGG; hsa:375593; -.
DR MANE-Select; ENST00000323819.8; ENSP00000318615.3; NM_198924.4; NP_944606.2.
DR UCSC; uc003udc.2; human.
DR AGR; HGNC:18162; -.
DR CTD; 375593; -.
DR DisGeNET; 375593; -.
DR GeneCards; TRIM73; -.
DR HGNC; HGNC:18162; TRIM73.
DR HPA; ENSG00000178809; Low tissue specificity.
DR MIM; 612549; gene.
DR neXtProt; NX_Q86UV7; -.
DR OpenTargets; ENSG00000178809; -.
DR PharmGKB; PA38510; -.
DR VEuPathDB; HostDB:ENSG00000178809; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000167700; -.
DR InParanoid; Q86UV7; -.
DR OMA; NAIACIT; -.
DR OrthoDB; 3453019at2759; -.
DR PhylomeDB; Q86UV7; -.
DR TreeFam; TF342569; -.
DR PathwayCommons; Q86UV7; -.
DR SignaLink; Q86UV7; -.
DR SIGNOR; Q86UV7; -.
DR BioGRID-ORCS; 375593; 39 hits in 1060 CRISPR screens.
DR GenomeRNAi; 375593; -.
DR Pharos; Q86UV7; Tdark.
DR PRO; PR:Q86UV7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q86UV7; Protein.
DR Bgee; ENSG00000178809; Expressed in fundus of stomach and 96 other cell types or tissues.
DR ExpressionAtlas; Q86UV7; baseline and differential.
DR Genevisible; Q86UV7; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd19787; Bbox2_TRIM50-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF326; E3 UBIQUITIN-PROTEIN LIGASE TRIM50-RELATED; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..250
FT /note="Tripartite motif-containing protein 73"
FT /id="PRO_0000056278"
FT ZN_FING 16..57
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 84..125
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 125..169
FT /evidence="ECO:0000255"
FT COILED 204..235
FT /evidence="ECO:0000255"
FT BINDING 89
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 92
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 111
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 117
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 250 AA; 28517 MW; 9DF7A64F66B36707 CRC64;
MAWQVSLLEL EDRLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV
DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH
PVTPVSTVCS RMKEELAALF SELKQEQKKV DELIAKLVKN RTRIVNESDV FSWVIRREFQ
ELRHPVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF
IWKFHSMASR
//
