GenomeNet

Database: UniProt
Entry: Q86XE0
LinkDB: Q86XE0
Original site: Q86XE0 
ID   SNX32_HUMAN             Reviewed;         403 AA.
AC   Q86XE0; Q8IW53; Q96NG4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 154.
DE   RecName: Full=Sorting nexin-32;
DE   AltName: Full=Sorting nexin-6B;
GN   Name=SNX32; Synonyms=SNX6B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Brain cortex;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ASN-155;
RP   VAL-282 AND TYR-354.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in several stages of intracellular
CC       trafficking. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q86XE0; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-8099743, EBI-7317823;
CC       Q86XE0; A0A0C4DGQ7: EML2; NbExp=3; IntAct=EBI-8099743, EBI-12112376;
CC       Q86XE0; A8MXD5: GRXCR1; NbExp=3; IntAct=EBI-8099743, EBI-5235612;
CC       Q86XE0; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-8099743, EBI-743811;
CC       Q86XE0; Q9Y5B8: NME7; NbExp=5; IntAct=EBI-8099743, EBI-744782;
CC       Q86XE0; Q13596: SNX1; NbExp=11; IntAct=EBI-8099743, EBI-2822329;
CC       Q86XE0; O60749: SNX2; NbExp=4; IntAct=EBI-8099743, EBI-1046690;
CC       Q86XE0; Q9NS25: SPANXB1; NbExp=3; IntAct=EBI-8099743, EBI-17197485;
CC       Q86XE0; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-8099743, EBI-1105213;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q86XE0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q86XE0-2; Sequence=VSP_031742, VSP_031743;
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; AK055496; BAB70935.1; -; mRNA.
DR   EMBL; AK289587; BAF82276.1; -; mRNA.
DR   EMBL; CH471076; EAW74441.1; -; Genomic_DNA.
DR   EMBL; BC040981; AAH40981.1; -; mRNA.
DR   EMBL; BC045563; AAH45563.1; -; mRNA.
DR   CCDS; CCDS8113.2; -. [Q86XE0-1]
DR   RefSeq; NP_689973.2; NM_152760.2. [Q86XE0-1]
DR   PDB; 6E8R; X-ray; 2.27 A; A/B=17-166.
DR   PDBsum; 6E8R; -.
DR   AlphaFoldDB; Q86XE0; -.
DR   SMR; Q86XE0; -.
DR   BioGRID; 129016; 30.
DR   IntAct; Q86XE0; 19.
DR   MINT; Q86XE0; -.
DR   STRING; 9606.ENSP00000310620; -.
DR   TCDB; 3.A.34.1.1; the sorting nexins of the escrt complexes (sn-escrt).
DR   GlyGen; Q86XE0; 2 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q86XE0; -.
DR   PhosphoSitePlus; Q86XE0; -.
DR   BioMuta; SNX32; -.
DR   DMDM; 74727816; -.
DR   jPOST; Q86XE0; -.
DR   MassIVE; Q86XE0; -.
DR   MaxQB; Q86XE0; -.
DR   PaxDb; 9606-ENSP00000310620; -.
DR   PeptideAtlas; Q86XE0; -.
DR   ProteomicsDB; 70267; -. [Q86XE0-1]
DR   ProteomicsDB; 70268; -. [Q86XE0-2]
DR   Antibodypedia; 29952; 147 antibodies from 21 providers.
DR   DNASU; 254122; -.
DR   Ensembl; ENST00000308342.7; ENSP00000310620.6; ENSG00000172803.18. [Q86XE0-1]
DR   GeneID; 254122; -.
DR   KEGG; hsa:254122; -.
DR   MANE-Select; ENST00000308342.7; ENSP00000310620.6; NM_152760.3; NP_689973.2.
DR   UCSC; uc001ofr.4; human. [Q86XE0-1]
DR   AGR; HGNC:26423; -.
DR   CTD; 254122; -.
DR   DisGeNET; 254122; -.
DR   GeneCards; SNX32; -.
DR   HGNC; HGNC:26423; SNX32.
DR   HPA; ENSG00000172803; Tissue enriched (brain).
DR   neXtProt; NX_Q86XE0; -.
DR   OpenTargets; ENSG00000172803; -.
DR   PharmGKB; PA162404314; -.
DR   VEuPathDB; HostDB:ENSG00000172803; -.
DR   eggNOG; KOG1660; Eukaryota.
DR   GeneTree; ENSGT00940000162773; -.
DR   HOGENOM; CLU_040966_0_0_1; -.
DR   InParanoid; Q86XE0; -.
DR   OMA; ETHQQLC; -.
DR   OrthoDB; 5398040at2759; -.
DR   PhylomeDB; Q86XE0; -.
DR   TreeFam; TF313698; -.
DR   PathwayCommons; Q86XE0; -.
DR   SignaLink; Q86XE0; -.
DR   BioGRID-ORCS; 254122; 33 hits in 1150 CRISPR screens.
DR   ChiTaRS; SNX32; human.
DR   GenomeRNAi; 254122; -.
DR   Pharos; Q86XE0; Tdark.
DR   PRO; PR:Q86XE0; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q86XE0; Protein.
DR   Bgee; ENSG00000172803; Expressed in right frontal lobe and 101 other cell types or tissues.
DR   Genevisible; Q86XE0; HS.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016241; P:regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   CDD; cd07621; BAR_SNX5_6; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR014637; SNX5/SNX6/SNX32.
DR   InterPro; IPR015404; Vps5_C.
DR   PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR45850:SF3; SORTING NEXIN-32; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF09325; Vps5; 1.
DR   PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Coiled coil; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..403
FT                   /note="Sorting nexin-32"
FT                   /id="PRO_0000320707"
FT   DOMAIN          20..168
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   COILED          258..335
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         238..277
FT                   /note="LADDYIPISAALSSLGTQEVNQLRTSFLKLAELFERLRKL -> TQGPRGPG
FT                   SPCPSPQRFNSLGERREQGVPCCLSVATSTKA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_031742"
FT   VAR_SEQ         278..403
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_031743"
FT   VARIANT         155
FT                   /note="H -> N (in dbSNP:rs17854065)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_039298"
FT   VARIANT         282
FT                   /note="A -> V (in dbSNP:rs17855647)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_039299"
FT   VARIANT         354
FT                   /note="S -> Y (in dbSNP:rs17857243)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_039300"
FT   CONFLICT        14
FT                   /note="S -> P (in Ref. 1; BAB70935)"
FT                   /evidence="ECO:0000305"
FT   STRAND          26..35
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   STRAND          40..48
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   STRAND          53..63
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   HELIX           64..76
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   HELIX           78..80
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   HELIX           95..106
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   HELIX           113..147
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   HELIX           151..153
FT                   /evidence="ECO:0007829|PDB:6E8R"
FT   HELIX           155..162
FT                   /evidence="ECO:0007829|PDB:6E8R"
SQ   SEQUENCE   403 AA;  46399 MW;  9100676299AE2C19 CRC64;
     METYAEVGKE GKPSCASVDL QGDSSLQVEI SDAVSERDKV KFTVQTKSCL PHFAQTEFSV
     VRQHEEFIWL HDAYVENEEY AGLIIPPAPP RPDFEASREK LQKLGEGDSS VTREEFAKMK
     QELEAEYLAI FKKTVAMHEV FLQRLAAHPT LRRDHNFFVF LEYGQDLSVR GKNRKELLGG
     FLRNIVKSAD EALITGMSGL KEVDDFFEHE RTFLLEYHTR IRDACLRADR VMRAHKCLAD
     DYIPISAALS SLGTQEVNQL RTSFLKLAEL FERLRKLEGR VASDEDLKLS DMLRYYMRDS
     QAAKDLLYRR LRALADYENA NKALDKARTR NREVRPAESH QQLCCQRFER LSDSAKQELM
     DFKSRRVSSF RKNLIELAEL ELKHAKASTL ILRNTLVALK GEP
//
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