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Database: UniProt
Entry: Q87114_SIVSA
LinkDB: Q87114_SIVSA
Original site: Q87114_SIVSA 
ID   Q87114_SIVSA            Unreviewed;       226 AA.
AC   Q87114;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   12-AUG-2020, entry version 88.
DE   RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344};
OS   Simian immunodeficiency virus - agm.sab-1.
OC   Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=349974 {ECO:0000313|EMBL:AAA21511.1, ECO:0000313|Proteomes:UP000260447};
RN   [1] {ECO:0000313|EMBL:AAA21511.1, ECO:0000313|Proteomes:UP000260447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIVagmSAB-1 {ECO:0000313|EMBL:AAA21511.1,
RC   ECO:0000313|Proteomes:UP000260447};
RX   PubMed=8026477;
RA   Jin M.J., Hui H., Robertson D.L., Muller M.C., Barre-Sinoussi F.,
RA   Hirsch V.M., Allan J.S., Shaw G.M., Sharp P.M., Hahn B.H.;
RT   "Mosaic genome structure of simian immunodeficiency virus from west African
RT   green monkeys.";
RL   EMBO J. 13:2935-2947(1994).
CC   -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein family.
CC       {ECO:0000256|ARBA:ARBA00006933, ECO:0000256|RuleBase:RU000344}.
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DR   EMBL; U04005; AAA21511.1; -; Genomic_DNA.
DR   Proteomes; UP000260447; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.62.10; -; 1.
DR   InterPro; IPR027481; HIV-1_Nef_core_sf.
DR   InterPro; IPR001558; HIV_Nef.
DR   Pfam; PF00469; F-protein; 1.
DR   SUPFAM; SSF55671; SSF55671; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Lipoprotein {ECO:0000256|RuleBase:RU000344};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU000344};
KW   Reference proteome {ECO:0000313|Proteomes:UP000260447};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280,
KW   ECO:0000256|RuleBase:RU000344};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|RuleBase:RU000344}.
FT   REGION          57..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  26071 MW;  424312E99A977521 CRC64;
     MGGKSSKQQQ RHSLWLWSKL RQAPVIQYDM LADPLLGQSS HIQEECAKSL RDGLIRQGDS
     SRTEEGVKMK HQGRQPSWYD EDEEEVGFPV RPCLPLRAMT YKLAIDFGHF LKEKGGLEGI
     YYSERRKKIL DLYALNEWGI VDGWQNYTDG PGTRYPKCFG WCFKLVPVDL SEEAKNSENH
     CLLHPAQVAY EDDAWKETLV WKFDPLLAVD YVAWRLHPEQ VPSAQG
//
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