ID MUTS_VIBPA Reviewed; 853 AA.
AC Q87LQ9;
DT 23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2003, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VP2552;
OS Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=223926;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633;
RX PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; BA000031; BAC60815.1; -; Genomic_DNA.
DR RefSeq; NP_798931.1; NC_004603.1.
DR RefSeq; WP_005478546.1; NC_004603.1.
DR AlphaFoldDB; Q87LQ9; -.
DR SMR; Q87LQ9; -.
DR GeneID; 1190076; -.
DR KEGG; vpa:VP2552; -.
DR PATRIC; fig|223926.6.peg.2450; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR Proteomes; UP000002493; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..853
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115165"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 853 AA; 94972 MW; ED3AD3A69A7F7CE7 CRC64;
MKAEQKHTPM MQQYLKLKAE NPEILLFYRM GDFYELFYDD AKRASQLLDI SLTKRGSSAG
EPIPMAGVPF HAVEGYLAKL VQLGESVAIC EQIGDPATSK GPVERKVVRI VTPGTVTDEA
LLSERLDNLI AAIYHHNGKF GYATLDVTSG RFQLTEPETE EAMMAELQRT APRELLFPED
FEPVHLMSNR NGNRRRPVWE FELDTAKQQL NQQFGTRDLV GFGVEHASLG LCAAGCLIQY
VKDTQRTALP HIRSLTFDRQ DHSVILDAAT RRNLEITQNL AGGTDNTLAA VLDHCSTPMG
SRMLKRWLHQ PMRCIDTLNN RLDAIGEIKD QGLFTDLQPT LKQIGDIERI LARLALRSAR
PRDMARLRHA MQQLPELESL TASLTHPYLV KLAQYAAPID EVCELLERAI KENPPVVIRD
GGVIAEGYNE ELDEWRKLAD GATEYLEKLE ADERERHGID TLKVGYNAVH GFFIQVSRGQ
SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLNSKSKAL ALEKKLWEEL FDLLMPHLEQ
MQNLASAVSQ MDVLQNLAER ADSLDYCRPT LVKDAGIHIQ AGRHPVVEQV TSDPFIANPI
ELSPSRKMLI ITGPNMGGKS TYMRQTALIA LMAHIGSYVP AESAQIGSLD RIFTRIGASD
DLASGRSTFM VEMTETANIL HNATKNSLVL MDEIGRGTST YDGLSLAWAS AEWLATQIGA
MTLFATHYFE LTELPNLLPN LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
PKTVIKNART KLSQLEQLGQ ASDSPRPSTV DVANQLSLIP EPSEIEQALS NIDPDDLTPR
QALEELYRLK KML
//
