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Database: UniProt
Entry: Q87S78_VIBPA
LinkDB: Q87S78_VIBPA
Original site: Q87S78_VIBPA 
ID   Q87S78_VIBPA            Unreviewed;       357 AA.
AC   Q87S78;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   OrderedLocusNames=VP0546 {ECO:0000313|EMBL:BAC58809.1};
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=223926 {ECO:0000313|EMBL:BAC58809.1, ECO:0000313|Proteomes:UP000002493};
RN   [1] {ECO:0000313|EMBL:BAC58809.1, ECO:0000313|Proteomes:UP000002493}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633 {ECO:0000313|Proteomes:UP000002493};
RX   PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; BA000031; BAC58809.1; -; Genomic_DNA.
DR   RefSeq; NP_796925.1; NC_004603.1.
DR   RefSeq; WP_005477886.1; NC_004603.1.
DR   STRING; 223926.28805529; -.
DR   EnsemblBacteria; BAC58809; BAC58809; BAC58809.
DR   GeneID; 1188014; -.
DR   KEGG; vpa:VP0546; -.
DR   PATRIC; fig|223926.6.peg.519; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   OMA; VMENVAN; -.
DR   BioCyc; VPAR223926:G1GTB-558-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002493};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002493};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       41    340       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   COILED       67     87       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   357 AA;  39694 MW;  472BB7EE55BA9684 CRC64;
     MQKSELSNIN ISDEQVLITP DELKVKLPLS EKARRFIQES RQTIANIIHK KDHRLLVVCG
     PCSIHDIEAA KDYAKRLKAL SEQLSDQLYI VMRVYFEKPR TTVGWKGLIN DPHLDGSFDI
     EHGLHVGREL LVELAEMEIP LATEALDPIS PQYLADTFSW AAIGARTTES QTHREMASGL
     SMPIGFKNGT DGSLATAINA MQAASSSHRF MGINREGQVA LLTTQGNPNG HVILRGGKQT
     NYDSVSVTEC EQEMAKSGLE ASLMVDCSHA NSRKDYRRQP LVAEDVIHQI REGNKSIIGL
     MIESHINEGN QSSELALDEM KYGVSITDAC INWESTEALL RHAHEELVPF LENRLKG
//
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