GenomeNet

Database: UniProt
Entry: Q885I9_PSESM
LinkDB: Q885I9_PSESM
Original site: Q885I9_PSESM 
ID   Q885I9_PSESM            Unreviewed;       410 AA.
AC   Q885I9;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-MAY-2019, entry version 114.
DE   RecName: Full=Aspartokinase {ECO:0000256|RuleBase:RU003448};
DE            EC=2.7.2.4 {ECO:0000256|RuleBase:RU003448};
GN   OrderedLocusNames=PSPTO_1843 {ECO:0000313|EMBL:AAO55362.1};
OS   Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=223283 {ECO:0000313|EMBL:AAO55362.1, ECO:0000313|Proteomes:UP000002515};
RN   [1] {ECO:0000313|EMBL:AAO55362.1, ECO:0000313|Proteomes:UP000002515}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-871 / DC3000 {ECO:0000313|Proteomes:UP000002515};
RX   PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA   Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA   Gwinn M.L., Dodson R.J., Deboy R.T., Durkin A.S., Kolonay J.F.,
RA   Madupu R., Daugherty S., Brinkac L., Beanan M.J., Haft D.H.,
RA   Nelson W.C., Davidsen T., Zafar N., Zhou L., Liu J., Yuan Q.,
RA   Khouri H., Fedorova N., Tran B., Russell D., Berry K., Utterback T.,
RA   Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.L., Ramos A.R.,
RA   Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P.,
RA   Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X., Bender C.L.,
RA   White O., Fraser C.M., Collmer A.;
RT   "The complete genome sequence of the Arabidopsis and tomato pathogen
RT   Pseudomonas syringae pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC         Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC         Evidence={ECO:0000256|RuleBase:RU003448};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC       {ECO:0000256|RuleBase:RU003448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AE016853; AAO55362.1; -; Genomic_DNA.
DR   RefSeq; NP_791667.1; NC_004578.1.
DR   RefSeq; WP_005731386.1; NC_004578.1.
DR   STRING; 223283.PSPTO_1843; -.
DR   EnsemblBacteria; AAO55362; AAO55362; PSPTO_1843.
DR   GeneID; 1183484; -.
DR   KEGG; pst:PSPTO_1843; -.
DR   PATRIC; fig|223283.9.peg.1872; -.
DR   eggNOG; ENOG4105CFH; Bacteria.
DR   eggNOG; COG0527; LUCA.
DR   HOGENOM; HOG000293093; -.
DR   KO; K00928; -.
DR   OMA; KNQARVS; -.
DR   OrthoDB; 1067792at2; -.
DR   PhylomeDB; Q885I9; -.
DR   BioCyc; PSYR223283:G1G0D-1879-MONOMER; -.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00461.
DR   UniPathway; UPA00051; UER00462.
DR   Proteomes; UP000002515; Chromosome.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04261; AAK_AKii-LysC-BS; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041740; AKii-LysC-BS.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF13840; ACT_7; 1.
DR   PIRSF; PIRSF000726; Asp_kin; 2.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 2.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000726-1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002515};
KW   Kinase {ECO:0000256|RuleBase:RU003448, ECO:0000313|EMBL:AAO55362.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000726-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002515};
KW   Transferase {ECO:0000256|RuleBase:RU003448}.
FT   DOMAIN      265    339       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   DOMAIN      345    410       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       7     10       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   NP_BIND     173    174       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   NP_BIND     209    210       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   BINDING      47     47       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000726-1}.
FT   BINDING      74     74       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000726-1}.
FT   BINDING     179    179       ATP; via amide nitrogen and carbonyl
FT                                oxygen. {ECO:0000256|PIRSR:PIRSR000726-
FT                                1}.
FT   BINDING     184    184       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
SQ   SEQUENCE   410 AA;  44459 MW;  AA7356AB52E212CD CRC64;
     MALIVQKFGG TSVGSVERIE QVADKVKKFR EAGDDLVVVL SAMSGETNRL IELARQISDQ
     PVPRELDVIV STGEQVTIAL LAMALMKRGV PAVSYTGNQV RILTDSAHNK ARILQIDDQK
     IRSDLKAGRV VVVAGFQGVD EHGNITTLGR GGSDTTGVAL AAALKADECQ IYTDVDGVYT
     TDPRVVSQAQ RLDKITFEEM LEMASLGSKV LQIRAVEFAG KYNVPLRVLH SFKEGPGTLI
     TIDEEESMEQ PIISGIAFNR DEAKLTIRGV PDTPGVAFKI LGPISAANIE VDMIVQNVSH
     DNTTDFTFTI HRNDYQAALQ VLETTAREIS AREVSGDTKI AKVSIVGVGM RSHAGVASRM
     FEALAKESIN IQMISTSEIK VSVVIEEKYL ELAVRALHTA FELDAPRQGE
//
DBGET integrated database retrieval system