ID Q88C36_PSEPK Unreviewed; 471 AA.
AC Q88C36;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Pyruvate carboxylase subunit A {ECO:0000313|EMBL:AAN70912.1};
DE EC=6.4.1.1 {ECO:0000313|EMBL:AAN70912.1};
GN Name=pycA {ECO:0000313|EMBL:AAN70912.1};
GN OrderedLocusNames=PP_5347 {ECO:0000313|EMBL:AAN70912.1};
OS Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS / KT2440).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=160488 {ECO:0000313|EMBL:AAN70912.1, ECO:0000313|Proteomes:UP000000556};
RN [1] {ECO:0000313|EMBL:AAN70912.1, ECO:0000313|Proteomes:UP000000556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440
RC {ECO:0000313|Proteomes:UP000000556};
RX PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA Martins dos Santos V.A., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA Brinkac L., Beanan M., DeBoy R.T., Daugherty S., Kolonay J., Madupu R.,
RA Nelson W., White O., Peterson J., Khouri H., Hance I., Chris Lee P.,
RA Holtzapple E., Scanlan D., Tran K., Moazzez A., Utterback T., Rizzo M.,
RA Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D.,
RA Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N.,
RA Dusterhoft A., Tummler B., Fraser C.M.;
RT "Complete genome sequence and comparative analysis of the metabolically
RT versatile Pseudomonas putida KT2440.";
RL Environ. Microbiol. 4:799-808(2002).
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DR EMBL; AE015451; AAN70912.1; -; Genomic_DNA.
DR RefSeq; NP_747448.1; NC_002947.4.
DR RefSeq; WP_003253279.1; NC_002947.4.
DR AlphaFoldDB; Q88C36; -.
DR STRING; 160488.PP_5347; -.
DR PaxDb; 160488-PP_5347; -.
DR GeneID; 83683153; -.
DR KEGG; ppu:PP_5347; -.
DR PATRIC; fig|160488.4.peg.5700; -.
DR eggNOG; COG0439; Bacteria.
DR HOGENOM; CLU_000395_3_2_6; -.
DR OrthoDB; 9763189at2; -.
DR PhylomeDB; Q88C36; -.
DR BioCyc; PPUT160488:G1G01-5703-MONOMER; -.
DR Proteomes; UP000000556; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004736; F:pyruvate carboxylase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR PANTHER; PTHR48095:SF1; BIOTIN CARBOXYLASE; 1.
DR PANTHER; PTHR48095; PYRUVATE CARBOXYLASE SUBUNIT A; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AAN70912.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Pyruvate {ECO:0000313|EMBL:AAN70912.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000556}.
FT DOMAIN 1..444
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 119..315
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 471 AA; 51942 MW; 81434A7F69FA7C83 CRC64;
MIKKILIANR GEIAVRIVRA CAEMGIRSVA IFSDADRHAL HVKRADEAHS IGAEPLAGYL
NPRKLVNLAV ETGCDALHPG YGFLSENAEL AEICAERGIK FIGPAADVIR RMGDKTEARR
TMIAAGVPVT PGTEGNVADI HEALSEGDRI GYPVMLKATS GGGGRGIRRC NSREELEQNF
PRVISEATKA FGSAEVFLEK CIVNPKHIEA QILGDSFGNV VHLFERDCSI QRRNQKLIEI
APSPQLTPEQ RAYIGDLAVR AAKAVNYENA GTVEFLLADG EVYFMEMNTR VQVEHTITEE
ITGIDIVREQ IRIASGLPLS VKQEDIQHRG YALQFRINAE DPKNNFLPSF GKITRYYAPG
GPGVRTDTAI YTGYTIPPFY DSMCLKLVVW ALTWEEAMDR GLRALDDMRV QGVKTTAAYY
QEILRNPEFR SGQFNTSFVE SHPELTNYSI KRKPEELALA IAAAIAAHAG L
//
