ID Q88LC1_PSEPK Unreviewed; 295 AA.
AC Q88LC1;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Rhomboid family intramembrane serine protease {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=PP_2014 {ECO:0000313|EMBL:AAN67628.1};
OS Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS / KT2440).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=160488 {ECO:0000313|EMBL:AAN67628.1, ECO:0000313|Proteomes:UP000000556};
RN [1] {ECO:0000313|EMBL:AAN67628.1, ECO:0000313|Proteomes:UP000000556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440
RC {ECO:0000313|Proteomes:UP000000556};
RX PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA Martins dos Santos V.A., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA Brinkac L., Beanan M., DeBoy R.T., Daugherty S., Kolonay J., Madupu R.,
RA Nelson W., White O., Peterson J., Khouri H., Hance I., Chris Lee P.,
RA Holtzapple E., Scanlan D., Tran K., Moazzez A., Utterback T., Rizzo M.,
RA Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D.,
RA Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N.,
RA Dusterhoft A., Tummler B., Fraser C.M.;
RT "Complete genome sequence and comparative analysis of the metabolically
RT versatile Pseudomonas putida KT2440.";
RL Environ. Microbiol. 4:799-808(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family.
CC {ECO:0000256|ARBA:ARBA00009045}.
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DR EMBL; AE015451; AAN67628.1; -; Genomic_DNA.
DR RefSeq; NP_744164.1; NC_002947.4.
DR RefSeq; WP_010953025.1; NC_002947.4.
DR AlphaFoldDB; Q88LC1; -.
DR STRING; 160488.PP_2014; -.
DR MEROPS; S54.028; -.
DR PaxDb; 160488-PP_2014; -.
DR GeneID; 83681477; -.
DR KEGG; ppu:PP_2014; -.
DR PATRIC; fig|160488.4.peg.2124; -.
DR eggNOG; COG0705; Bacteria.
DR HOGENOM; CLU_058989_1_0_6; -.
DR OrthoDB; 9778341at2; -.
DR PhylomeDB; Q88LC1; -.
DR BioCyc; PPUT160488:G1G01-2148-MONOMER; -.
DR Proteomes; UP000000556; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR Gene3D; 3.30.70.2080; -; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR031976; NRho.
DR InterPro; IPR038244; NRho_sf.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR PANTHER; PTHR43731:SF26; RHOMBOID DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43731; RHOMBOID PROTEASE; 1.
DR Pfam; PF16733; NRho; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000556};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..67
FT /note="Rhomboid protease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16733"
FT DOMAIN 143..285
FT /note="Peptidase S54 rhomboid"
FT /evidence="ECO:0000259|Pfam:PF01694"
SQ SEQUENCE 295 AA; 32151 MW; EA6F97113B1ACE62 CRC64;
MNIIEVMRLP LSVDLSGFVH LLQRLQVPHR VSEEGDAQVL WAPDTLAEDV LQLYQRYPDG
NADLPATADP VGAGAPANAP TQPSLAAQAK ACKITTLTLL LCFIVAGLTG LGDNFTTISW
FTFLDFRVQG DYLYFSPLAQ SLDEGQWWRL VSPMLLHFGV LHLAMNSLWY WELGKRIELR
QGPWALLGLT LLFSLVSNLA QHYTSGPSLF GGLSGVLYGL LGHIWLYQWL APDRYFNLPK
GVLVMMLIWL VVCLTGVVGT LGLGQIANAA HVGGLLIGCL TGLLGGALAR RKLSA
//
