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Database: UniProt
Entry: Q88LK2_PSEPK
LinkDB: Q88LK2_PSEPK
Original site: Q88LK2_PSEPK 
ID   Q88LK2_PSEPK            Unreviewed;       427 AA.
AC   Q88LK2;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   RecName: Full=Arsenical pump membrane protein {ECO:0000256|RuleBase:RU004993};
GN   Name=arsB-I {ECO:0000313|EMBL:AAN67546.1};
GN   OrderedLocusNames=PP_1929 {ECO:0000313|EMBL:AAN67546.1};
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 /
OS   KT2440).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488 {ECO:0000313|EMBL:AAN67546.1, ECO:0000313|Proteomes:UP000000556};
RN   [1] {ECO:0000313|EMBL:AAN67546.1, ECO:0000313|Proteomes:UP000000556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440
RC   {ECO:0000313|Proteomes:UP000000556};
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L., Beanan M., DeBoy R.T., Daugherty S., Kolonay J.,
RA   Madupu R., Nelson W., White O., Peterson J., Khouri H., Hance I.,
RA   Chris Lee P., Holtzapple E., Scanlan D., Tran K., Moazzez A.,
RA   Utterback T., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA   Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S.,
RA   Kiewitz C., Eisen J.A., Timmis K.N., Dusterhoft A., Tummler B.,
RA   Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the
RT   metabolically versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
CC   -!- FUNCTION: Involved in arsenical resistance. Thought to form the
CC       channel of an arsenite pump. {ECO:0000256|RuleBase:RU004993}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU004993}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU004993}.
CC   -!- SIMILARITY: Belongs to the ArsB family.
CC       {ECO:0000256|RuleBase:RU004993}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU004993}.
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DR   EMBL; AE015451; AAN67546.1; -; Genomic_DNA.
DR   RefSeq; NP_744082.1; NC_002947.4.
DR   RefSeq; WP_010952950.1; NC_002947.4.
DR   STRING; 160488.PP_1929; -.
DR   PRIDE; Q88LK2; -.
DR   EnsemblBacteria; AAN67546; AAN67546; PP_1929.
DR   GeneID; 1043133; -.
DR   KEGG; ppu:PP_1929; -.
DR   PATRIC; fig|160488.4.peg.2040; -.
DR   eggNOG; ENOG4107R5R; Bacteria.
DR   eggNOG; COG1055; LUCA.
DR   HOGENOM; HOG000005271; -.
DR   KO; K03893; -.
DR   OMA; EAGFFAW; -.
DR   BioCyc; PPUT160488:G1G01-2044-MONOMER; -.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd01118; ArsB_permease; 1.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   Pfam; PF02040; ArsB; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
DR   TIGRFAMs; TIGR00935; 2a45; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance {ECO:0000256|RuleBase:RU004993};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000556};
KW   Membrane {ECO:0000256|RuleBase:RU004993};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000556};
KW   Transmembrane {ECO:0000256|RuleBase:RU004993};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004993};
KW   Transport {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM     25     43       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM     52     70       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM     94    127       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM    134    155       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM    175    198       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM    222    241       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM    247    266       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM    278    296       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM    308    329       Helical. {ECO:0000256|RuleBase:RU004993}.
FT   TRANSMEM    401    423       Helical. {ECO:0000256|RuleBase:RU004993}.
SQ   SEQUENCE   427 AA;  45392 MW;  07236AD03BE6D918 CRC64;
     MLIAFLIFLV TIVLVIWQPK GLGVGWSAAL GAVVALLAGV VSLSDIPVVW QIVWNATATF
     IAVIIISLLL DEAGFFEWAA LHVARWGKGS SRKLFAFIIL LGAAVSALFA NDGAALILTP
     IVIAMLLALR FSPAATLAFV MAAGFIADTA SLPLVVSNLV NIVSADYFGI GFSEYASVMV
     PVNLVSIAAT LGMLLWFFRK DLPRTYELDQ LKAPEAAIRD KATFVAGWWV LALLLVGFFA
     IEPLGVPISA IAAACALILY LIAARGHVIS TRKVLKDAPW QVVVFSLGMY LVVYGLRNAG
     LTEYLTQILN VFAGYGIWGA SLGTGLLAAG LSSAMNNMPT VLVGALSIQS AEATGIVREA
     MVYANVIGCD LGPKITPIGS LATLLWLHVL ARKNIVITWG YYFRTGIVLT LPILLATLAA
     LAIRLSF
//
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