ID   Q899V4_CLOTE            Unreviewed;       767 AA.
AC   Q899V4;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 135.
DE   SubName: Full=Negative regulator of genetic competence mecB {ECO:0000313|EMBL:AAO34716.1};
GN   Name=mecB {ECO:0000313|EMBL:AAO34716.1};
GN   OrderedLocusNames=CTC_00060 {ECO:0000313|EMBL:AAO34716.1};
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717 {ECO:0000313|EMBL:AAO34716.1, ECO:0000313|Proteomes:UP000001412};
RN   [1] {ECO:0000313|EMBL:AAO34716.1, ECO:0000313|Proteomes:UP000001412}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88 {ECO:0000313|Proteomes:UP000001412};
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I.,
RA   Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT   disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
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DR   EMBL; AE015927; AAO34716.1; -; Genomic_DNA.
DR   RefSeq; WP_011098389.1; NC_004557.1.
DR   AlphaFoldDB; Q899V4; -.
DR   STRING; 212717.CTC_00060; -.
DR   GeneID; 24253228; -.
DR   KEGG; ctc:CTC_00060; -.
DR   HOGENOM; CLU_005070_4_0_9; -.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000001412; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001412}.
FT   DOMAIN          175..320
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          504..676
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          675..764
FT                   /note="Clp ATPase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01086"
FT   REGION          105..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   767 AA;  87961 MW;  FF444011956D57FE CRC64;
     MKLCSVCNKN VATIFTTRFE TGKPQIVGIC AECAKKMNIQ PLNQIIEAAG VTPEDMETYA
     EQMNKLLDNM DINELLNNDL FSNMINNMNG MNMFKVQDDF IDKDKNEENT NSERNKDKSE
     GNSNVKTRVK FKNKRRNLDK YAINLNDKAK DKKIDVVVGR DKEIERIIQI LNRRNKNNPI
     LIGEPGVGKT AIAEGLAVKI IEKNVPIKLF DKEIYLLDLT SVVAGTQFRG QFEGRMKAIV
     DEVTESENVI LVIDEVHNII GAGEAQGGAL NAANILKPAL ARGDIQVIGA TTLEEYRKYI
     EKDSALERRF QPILVEEPSV KETIEILNNI KIYYEDYHKV KISKKIIEEA VKLSERYITD
     RYLPDKAIDV IDEASSRVNL RNKNLVEFKI AKEELGELQN KMLNEANSGN YEKAAQYKTE
     EYKLKNKVEE LEKKSKVELS VDDIAYVIEA WTKIPVQKVR EKEAEKLLNL EQRLHKRLIG
     QDKAVRKLSR TIRRNRLGFK SKKRPASFIF VGPTGVGKTE LVRSLACELF GDEDSLIRID
     MSEYMEKHTA SKLIGSPPGY VGYDEGGQLT EKIRRKPYSV VLLDEIEKAH PDIFNMLLQV
     LEDGRLTDNQ GRTVFFDNSV IIMTSNLGTN FKESSIGFGN TNSIQIENSI KDALKETFKP
     EFINRIDEIV IFEKLNKEEL YDIIDIMFDE VSEDLSEKNI KVHFTKEVKD FILKVGYDEK
     YGARELKRAI QRYIEDEISE QYFRNEVKEG TNILVDIYEE SIYIKNM
//