ID Q8A3A0_BACTN Unreviewed; 659 AA.
AC Q8A3A0;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:AAO78160.1};
GN OrderedLocusNames=BT_3054 {ECO:0000313|EMBL:AAO78160.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO78160.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO78160.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO78160.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
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DR EMBL; AE015928; AAO78160.1; -; Genomic_DNA.
DR RefSeq; NP_811966.1; NC_004663.1.
DR RefSeq; WP_008761732.1; NZ_UYXG01000001.1.
DR AlphaFoldDB; Q8A3A0; -.
DR STRING; 226186.BT_3054; -.
DR PaxDb; 226186-BT_3054; -.
DR DNASU; 1071842; -.
DR EnsemblBacteria; AAO78160; AAO78160; BT_3054.
DR GeneID; 60924238; -.
DR KEGG; bth:BT_3054; -.
DR PATRIC; fig|226186.12.peg.3112; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_7_0_10; -.
DR InParanoid; Q8A3A0; -.
DR OrthoDB; 9806724at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0000104; F:succinate dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0009061; P:anaerobic respiration; IBA:GO_Central.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR011280; Succ_DH/Fum_Rdt_flav_su.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01811; sdhA_Bsu; 1.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF53; SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414}.
FT DOMAIN 36..460
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 522..657
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT ACT_SITE 338
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630664-50"
SQ SEQUENCE 659 AA; 73251 MW; B4FE096E29B02766 CRC64;
MIKIDSKIPE GPVAEKWTNY KAHQKLVNPA NKRRLDIIVV GTGLAGASAA ASLGEMGFRV
FNFCIQDSPR RAHSIAAQGG INAAKNYQND GDSVYRLFYD TVKGGDYRAR EANVYRLAEV
SNAIIDQCVA QGVPFAREYG GTLDNRSFGG AQVSRTFYAK GQTGQQLLLG AYSALSRQVN
VGTVKLFTRY EMQDVVIIDG RARGIIAKNL ITGELERFAA HAVVIATGGY GNAYFLSTNA
MGCNCTAAIS CYRKGAVFAN PAYVQIHPTC IPVHGDKQSK LTLMSESLRN DGRIWVPKKK
EDAIKLQKGE IKGSDIPEED RDYYLERRYP AFGNLVPRDV ASRAAKERCD AGFGVNNTGL
AVFLDFSEAI NRLGIDVVLQ RYGNLFDMYE EITDVNPGEL AKEISGVKYY NPMMIYPAIH
YTMGGIWVDY ELQTTIKGLF AIGECNFSDH GANRLGASAL MQGLADGYFV LPYTIQNYLA
DQITVPRFST DLPEFAEAEK AVQAKIDKFM SIQGKESVDS IHKKLGHIMW EYVGMGRTAE
GLKKGIAELK AVRKEFETNL FIPGSKEGMN VELDKAIRLY DFITMGELVA YDALNRNESC
GGHFREEYQT EEGEAKRDDE NFFYVACWEY QGDDEKAPVL IKEPLVYEAI KVQTRNYKS
//
