ID Q8A3L1_BACTN Unreviewed; 552 AA.
AC Q8A3L1;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 24-JAN-2024, entry version 107.
DE SubName: Full=Hexapeptide transferase family protein {ECO:0000313|EMBL:AAO78049.1};
GN OrderedLocusNames=BT_2943 {ECO:0000313|EMBL:AAO78049.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO78049.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO78049.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO78049.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
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DR EMBL; AE015928; AAO78049.1; -; Genomic_DNA.
DR RefSeq; NP_811855.1; NC_004663.1.
DR RefSeq; WP_011108543.1; NC_004663.1.
DR AlphaFoldDB; Q8A3L1; -.
DR STRING; 226186.BT_2943; -.
DR PaxDb; 226186-BT_2943; -.
DR DNASU; 1072615; -.
DR EnsemblBacteria; AAO78049; AAO78049; BT_2943.
DR GeneID; 60924126; -.
DR KEGG; bth:BT_2943; -.
DR PATRIC; fig|226186.12.peg.2992; -.
DR eggNOG; COG0110; Bacteria.
DR HOGENOM; CLU_493205_0_0_10; -.
DR InParanoid; Q8A3L1; -.
DR OrthoDB; 6315394at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd03360; LbH_AT_putative; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR020019; AcTrfase_PglD-like.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR039523; RimK-rel_E_lig_ATP-grasp.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR NCBIfam; TIGR03570; NeuD_NnaD; 1.
DR PANTHER; PTHR43300; ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR43300:SF7; UDP-N-ACETYLBACILLOSAMINE N-ACETYLTRANSFERASE; 1.
DR Pfam; PF14397; ATPgrasp_ST; 1.
DR Pfam; PF00132; Hexapep; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Transferase {ECO:0000313|EMBL:AAO78049.1}.
FT DOMAIN 288..545
FT /note="Alpha-L-glutamate ligase-related protein ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF14397"
FT ACT_SITE 135
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR620019-1"
FT BINDING 67
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR620019-2"
FT SITE 136
FT /note="Increases basicity of active site His"
FT /evidence="ECO:0000256|PIRSR:PIRSR620019-1"
SQ SEQUENCE 552 AA; 61772 MW; FFFAA7F5B4D17B0B CRC64;
MVIIGSKGCA KEILTALKWD NVEETVSLFD NINTDISDAY YDFPIIKSWN ELEQHLKTDS
KVIIGVGGGQ RREVLARKIA CLGGVLTTFI SQKALVGGYD NTIEPGVVIL SGATITCNVS
IGQGTFINKS TVISHDVRIG RYCEVSPGAK VLGRAIIGDR TEIGANAVIL PDVIVGADCK
IGAGAVVTRN IDSHTTVAGV PARSITKSSN NAFKLKSKIR NLLYHIRIAD FRKLREYNHY
VFGKRKLMFL ELLSHSWMYG ASFENYYELQ FFKKSRTECR QYLTSSLRHE LTRQVNDPCE
ALVLKDKVRF SEVFEDILGR RVMTFDEIKR QMHDPYSISI NEVVIKPIKG QAGQGIIFPM
QNFTSLRQLH DYVISTVKKP DEYLYEERII QHSALNKLNP SSLNTLRIVT YYDESINKVD
VWSVVLRIGI KARTDNFATG GIAVLVDHRG VVCQPAIIKH PSGERFHIHP VSGEKITGCI
IPYYDQAIAL AKQAAMRIPK VRSIGWDVAI TETGPYMLEG NDNWCMTLFQ LPGGEGLRHL
ANSVCNMFSV YE
//
